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Phenoxazine

General Description Properties Uses Preparation Hazards

Phenoxazine

CAS No.135-67-1
Chemical Name:Phenoxazine
CBNumber:CB7329656
Molecular Formula:C12H9NO
Formula Weight:183.21
MOL File:135-67-1.mol

Phenoxazine Property

Melting point 156-159 °C (lit.)
Boiling point 316.88°C (rough estimate)
Density 1.1261 (rough estimate)
refractive index 1.5880 (estimate)
RTECS SP7450000
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility benzene: freely soluble(lit.)
pka 1.80±0.20(Predicted)
form Fine Crystalline Powder
color Gray to green-gray
Water Solubility Soluble in methanol. Insoluble in water.
Merck 14,7253
BRN 143234
InChIKey TZMSYXZUNZXBOL-UHFFFAOYSA-N
CAS DataBase Reference 135-67-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII C2ZWT499SG
NIST Chemistry Reference Phenoxazine(135-67-1)
UNSPSC Code 12352100
NACRES NA.22

Safety

Safety Statements :22-24/25-25-24
WGK Germany :3
HS Code :29349990

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H336-H225
Precautionary statements P501-P261-P240-P210-P233-P243-P241-P242-P271-P280-P370+P378-P303+P361+P353-P304+P340+P312-P403+P233-P403+P235-P405

Phenoxazine Price More Price(6)

Brand: Sigma-Aldrich(India)
Product number: P14858
Product name : Phenoxazine
Purity: 97%
Packaging: 1G
Price: ₹4102.68
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: P14858
Product name : Phenoxazine
Purity: 97%
Packaging: 5G
Price: ₹15133.35
Updated: 2022/06/14
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Brand: ALFA India
Product number: ALF-L01969-06
Product name : Phenoxazine, 98%
Purity:
Packaging: 5g
Price: ₹16273
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-L01969-03
Product name : Phenoxazine, 98%
Purity:
Packaging: 1g
Price: ₹3134
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: P0899
Product name : Phenoxazine
Purity: min. 98.0 %
Packaging: 1G
Price: ₹3300
Updated: 2022/05/26
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Phenoxazine Chemical Properties,Usage,Production

General Description Phenoxazine (C12H9NO) is a heterocyclic compound whose structure consists of an oxazine bonded to 2 benzene rings. It forms the nucleus of a wide variety of pharmaceutical molecules and dye-stuffs. It is a grey to off-white powder with a purity of 98% that acts as a transitional agent for 4,6-bis(diphenylphosphino)phenazine, and it can also be applied as a transitional agent for catalysts, pharmaceuticals, and oled.
Properties Phenoxazine has a molecular weight of 183.21 g/mol and a monoisotopic mass of 183.068 g/mol, which is also its exact mass. The compound has a heavy atom count of 14 and a complexity of 187. Phenoxazine has a melting point of 1560 C and it dissolves in water at the rate of 2.130 mg/l at 250 C
Uses Phenoxazine and its derivatives are not widely used hence the oxazine dyes are the only commercially viable derivatives. Certain oxazine dyes such as Nile blue dye is used in the preferential staining of brain cancer tissue since some of these dyes can inhibit the growth of these tumors. Various studies have explored the methods of preparation of boronic acids in a way that can result in a boron derivative of Phenoxazine (Nile blue dyes) which can be beneficial in cancer chemotherapy.
Preparation The preparation of Phenoxazine and its by-products revolves around cyclization reactions. Each reaction is distinct from the other based on the starting materials and the conditions applied to the preparation process. Most cyclization reactions involved in the production of Phenoxazine and its by-products take place through one crucial step reactions as opposed to a series of steps where an aryl ether or an aryl amine would be obtained.
Hazards The toxicological effects of Phenoxazine have not been investigated thoroughly but exposure to the compound may harm the eyes, skin, digestive tract and respiratory tract through irritation.
Chemical Properties grey to green-grey fine crystalline powder
Uses Phenoxazine is a tricyclic 2′deoxycytidine analog that has been used to improve stacking interactions between heterocycles of oligonucleotide/RNA hybrids and to enhance cellular uptake.
Definition ChEBI: 10H-phenoxazine is a member of the class of phenoxazines that is morpholine which is ortho-fused to two benzene rings at positions 2-3 and 5-6. It has a role as a ferroptosis inhibitor and a radical scavenger.
General Description Phenoxazine dyes, including several Nile blue analogs, are known to localize selectively in animal tumors.
Purification Methods Crystallise phenoxazine from EtOH and sublime it in vacuo. If too impure then extract it in a Soxhlet extractor using toluene. Evaporate the solvent and dissolve the residue (ca 100g) in *C6H6 (1L), CARCINOGEN (use an efficient fume cupboard) and chromatograph it through an Al2O3 column (50 x 450 mm) using *C6H6. The eluent (ca 3L) is evaporated to ca 150mL and cooled when ca 103g of phenoxazine m 149-153o is obtained. Sublimation yields platelets m 158-159o. It forms a green picrate m 141.5-142o. [Gilman & Moore J Am Chem Soc 79 3485 1957, Müller et al. J Org Chem 24 37 1959, Beilstein 27 I 223, 27 III/IV 1209.]