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Sinegin 3

Sinegin 3 Structure
Sinegin 3
  • CAS No.35906-36-6
  • Chemical Name:Sinegin 3
  • CBNumber:CB72654127
  • Molecular Formula:C75H112O35
  • Formula Weight:1573.67
  • MOL File:35906-36-6.mol
Sinegin 3 Property
  • Density 1.54±0.1 g/cm3 (20 ºC 760 Torr)
  • solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
  • form Powder
  • pka 4.14±0.70(Predicted)
  • color White to off-white
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Sinegin 3 Chemical Properties,Usage,Production

  • Uses Onjisaponin B is an orally active natural product derived from Polygala tenuifolia. Onjisaponin B inhibits NF-κB p65. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin. Onjisaponin B reduces β-amyloid (Aβ) production. Onjisaponin B reduces radiation-induced cell apoptosis. Onjisaponin B has anti-oxidant and anti-inflammatory activities. Onjisaponin B can be used for neurological disease and radiation injury study, and its metabolite tenuifolin (TF) can enter the brain through the BBB[1][2][3][4].
  • Definition ChEBI: Senegin III is a triterpenoid saponin isolated from Polygala senega var latifolia and has been shown to exhibit hypoglycemic activity. It has a role as a hypoglycemic agent and a plant metabolite. It is a cinnamate ester, a hydroxy monocarboxylic acid, a pentacyclic triterpenoid and a triterpenoid saponin. It is functionally related to a 4-methoxycinnamic acid. It derives from a hydride of an oleanane.
  • in vivo

    Onjisaponin B (40 mg/kg; i.g.; once) cannot pass through the blood-brain barrier (BBB), but its metabolite tenuifolin (TF) can enter the brain through the BBB in mice[2].
    Onjisaponin B (20-40 mg/kg; i.g.; daily for 12 days) ameliorates dopaminergic (DA) neurodegeneration in a MPTP (HY-15608)-induced mouse model of Parkinson’s disease (PD) through anti-oxidant and anti-inflammatory activities mediated via the RhoA/ROCK2 signaling pathway[2].
    Onjisaponin B (10 mg/kg; p.o.; daily from 4 to 7 months of age) reduces β-amyloid production and improve cognitive impairments in transgenic mice[3].
    Onjisaponin B (2.5 mg/kg; p.o.; 4 days prior to irradiation) significantly reduces pathological changes and apoptosis and the nuclear translocation of p65 in the lung tissue of p65+/- mice following radiation[4].

    Animal Model:C57BL/6J-Relaem1Smoc mice (p65+/- mice)[4]
    Dosage:2.5 mg/kg
    Administration:Oral gavage (p.o.); 4 days prior to irradiation
    Result:Inhibited p65 and cas3 activation caused by p65, and significantly reduced pathological changes and apoptosis (caused by down-regulation of p65) and the nuclear translocation of p65 in the lung tissue of p65+/- mice following radiation, but not in the thymus.
    Animal Model:C57BL/6J mice (male, 12 weeks old)[2]
    Dosage:20, 40 mg/kg
    Administration:Intragastric gavage (i.g.); daily for 12 days
    Result:Had a neuroprotective effect on MPTP (HY-15608) induced Parkinson’s disease (PD) model mice.
    Recovered MPTP-induced motor impairment.
    Reduced the number of ionized calcium-binding adapter molecule 1 (IBA-1)-positive cells, suppressed microglial activation induced by MPTP.
    Inhibited the secretion of IL-1β, TNF-α, and IL-6.
    Decreased MDA levels but increased SOD levels, exerted antioxidant abilities in PD model mice.
    Animal Model:APPswe/PS1ΔE9 (APP/PS1) double-transgenic mice[3]
    Dosage:10 mg/kg (200 μL (1 mg/mL) per 20 g body weight)
    Administration:Oral gavage (p.o.); daily from 4 to 7 months of age
    Result:No obvious toxic effects in mice.
    Did not alter mouse locomotor activity.
    Ameliorated cognitive impairments in amyloid precursor protein (APP)/ presenilin 1 (PS1) mice.
    Showed significantly lower numbers of 6E10-positive Aβ plaque and reduced plaque area.
  • References [1] Wu AG, et al. Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells. Int J Mol Sci. 2013 Nov 15;14(11):22618-41. DOI:10.3390/ijms141122618
    [2] Peng F, et al. The onjisaponin B metabolite tenuifolin ameliorates dopaminergic neurodegeneration in a mouse model of Parkinson's disease. Neuroreport. 2020 Apr 8;31(6):456-465. DOI:10.1097/WNR.0000000000001428
    [3] Li X, et al. Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments. PLoS One. 2016 Mar 8;11(3):e0151147. DOI:10.1371/journal.pone.0151147
    [4] Wang TY, et al. Targeting p65 to inhibit Cas3 transcription by Onjisaponin B for radiation damage therapy in p65+/- mice. Phytomedicine. 2022 Sep;104:154317. DOI:10.1016/j.phymed.2022.154317
Sinegin 3 Preparation Products And Raw materials
Raw materials
Preparation Products
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Sinegin 3 Spectrum
35906-36-6, Sinegin 3Related Search:
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  • C75H114O35
  • C75H112O35
  • 远志皂苷B,10 MM DMSO 溶液
  • 远志皂苷B/HPLC
  • 远志精Ⅲ
  • 远志皂苷B对照品,
  • 远志皂甙B
  • 远志皂苷B(标准品)
  • 远志皂苷B,远志精Ⅲ
  • 35906-36-6
  • Onjisaponin B, 10 mM in DMSO
  • Olean-12-ene-23,28-dioic acid, 3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-, 28-[O-6-deoxy-α-L-mannopyranosyl-(1→3)-O-[O-β-D-galactopyranosyl-(1→4)-O-β-D-xylopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→2)]-6-deoxy-4-O-[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-galactopyranosyl] ester, (2β,3β,...
  • Sinegin 3
  • Senegin III
  • Onjisaponin B
  • Onjisaponin B, >=98%

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