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SENEGENIN

SENEGENIN Structure
SENEGENIN
  • CAS No.2469-34-3
  • Chemical Name:SENEGENIN
  • CBNumber:CB2222527
  • Molecular Formula:C30H45ClO6
  • Formula Weight:537.13
  • MOL File:2469-34-3.mol
SENEGENIN Property
  • Melting point 290-292℃
  • Boiling point 674.1±55.0 °C(Predicted)
  • alpha D +19° (c = 0.70 in ethanol)
  • Density 1.28
  • storage temp. 2-8°C
  • solubility DMSO: soluble10mg/mL, clear
  • pka 4.27±0.70(Predicted)
  • form powder
  • color white to beige
  • FDA UNII 06S1QH951L
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
  • WGK Germany  :3
  • RTECS  :RC8815000
  • Toxicity :LD50 intraperitoneal in mouse: 3mg/kg
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P301+P312+P330
SENEGENIN Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1001
  • Product name : Senegenin
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹11528.63
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1001
  • Product name : Senegenin
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹46515.03
  • Updated: 2022/06/14
  • Buy: Buy

SENEGENIN Chemical Properties,Usage,Production

  • Description Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.
  • Uses Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.
  • Definition ChEBI: Senegenin is a 12alpha-hydroxy steroid.
  • in vivo

    Tenuigenin (2, 4, 8 mg/kg) significantly attenuates S.aureus-induced lung histopathological changes. Tenuigenin also inhibits lung wet/dry (W/D) ratio, and inflammatory cytokines TNF-α and IL-1β production in Male BALB/c mice[1].

  • IC 50 NF-κB
SENEGENIN Preparation Products And Raw materials
Raw materials
Preparation Products
SENEGENIN Suppliers
Global(193)Suppliers
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29858
  • Advantage：58
SENEGENIN Spectrum
2469-34-3, SENEGENINRelated Search:
  • standardized herbal extract
  • reference standards from Chinese medicinal herbs (TCM).
  • phytochemical
  • pharmaceutical intermediate
  • chemical reagent
  • 萜类
  • 抑制剂
  • 天然产物
  • 试剂
  • 标准品 -中药标准品
  • 三萜
  • 标准品-中药标准品
  • 标准品，对照品
  • 标准品-对照品
  • 分析试剂标准品
  • 植提标准品
  • 植物提取物
  • 标准品
  • 中药对照品
  • 对照品
  • C30H45ClO6
  • 远志皂苷元,10 MM DMSO 溶液
  • 远志皂甙元对照品
  • 远志皂甙元标准品
  • 标准品对照品】SENEGENIN
  • 远志皂甙元
  • 远志皂苷元对照品,
  • SENEGENIN 远志皂苷元 标准品
  • 远志皂苷
  • 遠志酸
  • 远志皂苷元(标准品)
  • SENEGENIN 远志皂苷元
  • 原志皂苷元
  • 远志皂苷元
  • 2469-34-3
  • Tenuigenin (Senegenin)
  • Tenuigenin, 10 mM in DMSO
  • Senegenin-RM
  • Senegenin (6CI)
  • 13-(Chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4,4a,5,6,6a,7,8,9,10,11,12,12a,13,14,14a,14b-octadecahydro-4,8a(1H)-picenedicarboxylic acid
  • (2S,3R,4S,4aR,6aR,8aS,12aS,13S,14aR,14bR)-13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid
  • Tenuifgenin
  • 13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid
  • Senegenin, >=98%
  • 12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid
  • (2beta,3beta,4alpha,12alpha)-12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid
  • Tenuifolic acid
  • 12α-Chloromethyl-2β,3β-dihydroxy-27-norolean-1-ene-23,28-dioic acid
  • 12α-(Chloromethyl)-2β,3β-dihydroxy-27-nor-5α-olean-13-ene-23,28-dioic acid
  • Tenuigenin
  • 27-Norolean-13-ene-23,28-dioicacid, 12-(chloromethyl)-2,3-dihydroxy-, (2β,3β,4α,12α)-
  • 28-dioicacid,12-(chloromethyl)-2-beta,3-beta-dihydroxy-27-noro-13-ene-2
  • SENEGIN
  • SENEGENIN

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