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HS-PEG4-CH2CH2COOH

HS-PEG4-CH2CH2COOH Structure
HS-PEG4-CH2CH2COOH
  • CAS No.749247-06-1
  • Chemical Name:HS-PEG4-CH2CH2COOH
  • CBNumber:CB72546907
  • Molecular Formula:C11H22O6S
  • Formula Weight:282.35
  • MOL File:749247-06-1.mol
HS-PEG4-CH2CH2COOH Property
  • Boiling point 422.9±45.0 °C(Predicted)
  • Density 1.156±0.06 g/cm3(Predicted)
  • storage temp. -20°C
  • pka 4.28±0.10(Predicted)
  • form Liquid
  • color Colorless to light yellow
  • UNSPSC Code 12352106
  • NACRES NA.22
Safety
  • HS Code  :2930909899
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P362-P403+P233-P405-P501

HS-PEG4-CH2CH2COOH Chemical Properties,Usage,Production

  • Description Thiol-PEG4-acid is a PEG linker containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
  • Uses Thiol-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • reaction suitability reaction type: Pegylations
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
HS-PEG4-CH2CH2COOH Preparation Products And Raw materials
Raw materials
Preparation Products
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HS-PEG4-CH2CH2COOH Spectrum
749247-06-1, HS-PEG4-CH2CH2COOHRelated Search:
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  • Propanoicacid, 3-[2-[2-[2-(2-Mercaptoethoxy)ethoxy]ethoxy]ethoxy]-
  • Thiol-dPEG 4 acid
  • SH-PEG4-COOH
  • HS-PEG4-CH2CH2COOH

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