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Difluoromethyl phenyl sulfone

CAS No.1535-65-5
Chemical Name:Difluoromethyl phenyl sulfone
CBNumber:CB72485024
Molecular Formula:C7H6F2O2S
Formula Weight:192.18
MOL File:1535-65-5.mol

Difluoromethyl phenyl sulfone Property

Melting point 24-25℃
Boiling point 115-120 °C(Press: 7 Torr)
Density 1.348
refractive index 1.5000
Flash point 128℃
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Chloroform (Slightly), Methanol (Slightly)
form liquid
color colorless
Water Solubility Soluble in chloroform and water.
BRN 2259218
UNSPSC Code 12352101
NACRES NA.22

Safety

Hazard Codes :Xi
Risk Statements :36/38
Safety Statements :26-24/25
WGK Germany :3
TSCA :No
HS Code :29309090

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319
Precautionary statements P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313

Difluoromethyl phenyl sulfone Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: 742600
Product name : Difluoromethyl phenyl sulfone
Purity: ≥97%
Packaging: 1G
Price: ₹5542.4
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 742600
Product name : Difluoromethyl phenyl sulfone
Purity: ≥97%
Packaging: 10G
Price: ₹45345.93
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: D4764
Product name : Difluoromethyl Phenyl Sulfone
Purity: min. 98.0 %
Packaging: 1G
Price: ₹4300
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: D4764
Product name : Difluoromethyl Phenyl Sulfone
Purity: min. 98.0 %
Packaging: 5G
Price: ₹20700
Updated: 2022/05/26
Buy: Buy

Difluoromethyl phenyl sulfone Chemical Properties,Usage,Production

Description Difluoromethyl phenyl sulfone is a powerful nucleophilic difluoromethylation reagent due to the high reactivity of the sulfonyl-stabilized difluoromethyl anion towards many electrophiles including carbonyls, imines, alkyl halides, and cyclic sulfates and sulfamidates. In the nucleophilic reaction step, depending on the substrate structure, strong bases are used to generate the nucleophilic (phenylsulfonyl)difluoromethyl anion in situ. In the desulfonylation step, sodium/mercury amalgam and magnesium are the commonly used reductive reagents. Besides, the (phenylsulfonyl)difluoromethylated compounds can undergo β-elimination to afford gem-difluoroalkenes.
Chemical Properties light yellow liquid
Uses Efficient reagent for difluoromethylation of carbonyls and aldehydes.
Uses Difluoromethyl Phenyl Sulfone has been used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls
Reactions (1) Difluoromethylation of alkyl halides.

(2) Difluoromethylation of aldehydes and ketones.

(3) Difluoromethylenation of aldimines and ketimines.

(4) Difluoromethylation of cyclic sulfates and sulfamidates.

(5) (Phenylsulfonyl)difluoromethylation of carboxylic acid esters.

(6) Difluoromethylenation of alkyl halides.

(7) Difluoromethylenation of aromatic aldehydes.
References [1] G. PRAKASH. Nucleophilic difluoromethylation of primary alkyl halides using difluoromethyl phenyl sulfone as a difluoromethyl anion equivalent.[J]. Organic Letters, 2004. DOI:10.1002/CHIN.200509059.
[2] G. K. SURYA PRAKASH. Difluoromethyl Phenyl Sulfone, a Difluoromethylidene Equivalent: Use in the Synthesis of 1,1-Difluoro-1-alkenes.[J]. ChemInform, 2005. DOI:10.1002/chin.200504098.
[3] G. K. SURYA PRAKASH. Nucleophilic Difluoromethylation of Primary Alkyl Halides Using Difluoromethyl Phenyl Sulfone as a Difluoromethyl Anion Equivalent[J]. Organic Letters, 2004, 6 23: 4315-4317. DOI:10.1021/ol048166i.