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(Difluoromethyl)trimethylsilane

(Difluoromethyl)trimethylsilane Structure
(Difluoromethyl)trimethylsilane
  • CAS No.65864-64-4
  • Chemical Name:(Difluoromethyl)trimethylsilane
  • CBNumber:CB02610597
  • Molecular Formula:C4H10F2Si
  • Formula Weight:124.2
  • MOL File:65864-64-4.mol
(Difluoromethyl)trimethylsilane Property
  • Boiling point 52°C(lit.)
  • Density 0.877±0.06 g/cm3(Predicted)
  • refractive index 1.3560-1.3600
  • Flash point -17℃
  • storage temp. Keep in dark place,Inert atmosphere,2-8°C
  • form clear liquid
  • color Colorless to Almost colorless
  • Specific Gravity 0.91
  • Hydrolytic Sensitivity 4: no reaction with water under neutral conditions
  • BRN 2423974
  • InChIKey OOKFLLNDYNWCHK-UHFFFAOYSA-N
  • CAS DataBase Reference 65864-64-4
  • UNSPSC Code 12352101
  • NACRES NA.22
Safety
  • Hazard Codes  :F
  • Risk Statements  :11
  • Safety Statements  :15-7-35
  • RIDADR  :UN 1993BF 3 / PGII
  • WGK Germany  :3
  • HazardClass  :3
  • PackingGroup  :II
  • HS Code  :29319090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H225
  • Precautionary statements P210
(Difluoromethyl)trimethylsilane Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: 744050
  • Product name : (Difluoromethyl)trimethylsilane
  • Purity: ≥98.0% (GC)
  • Packaging: 1ML
  • Price: ₹16183.38
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 744050
  • Product name : (Difluoromethyl)trimethylsilane
  • Purity: ≥98.0% (GC)
  • Packaging: 5ML
  • Price: ₹83872.1
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D4364
  • Product name : (Difluoromethyl)trimethylsilane
  • Purity: min. 97.0 %
  • Packaging: 1ML
  • Price: ₹7800
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D4364
  • Product name : (Difluoromethyl)trimethylsilane
  • Purity: min. 97.0 %
  • Packaging: 5ML
  • Price: ₹23500
  • Updated: 2022/05/26
  • Buy: Buy

(Difluoromethyl)trimethylsilane Chemical Properties,Usage,Production

  • Description A direct nucleophilic difluoromethylation reagent. The nucleophilic activation of the silicon center with Lewis base initiators allows transfer of the difluoromethyl moiety to electrophiles such as aldehydes, ketones, and aldimines. The copper-mediated difluoromethylation of halides using TMSCF2H tolerates amine, ether, amide, ester, aromatic bromide, and protected alcohol functionalities in aryl iodides and occurs in high yield and stereoselectivity with vinyl iodides.
  • Uses (Difluoromethyl)trimethylsilane, can be used for difluoromethylation of carbonyl compounds. Difluromethylated compounds are very useful in materials science and medicinal and agricultural chemistry.
  • Reactions (1) Direct bromination to prepare TMSCF2Br.
    Direct bromination to prepare TMSCF2Br.
    (2) Difluoromethylation of aldehydes and ketones.
    Difluoromethylation of aldehydes and ketones.
    (3) Difluoromethylation of aldimines.
    Difluoromethylation of aldimines.
    (4) Difluoromethylation of aryl and vinyl iodides.
    Difluoromethylation of aryl and vinyl iodides.
  • References [1] MIKHAIL D. KOSOBOKOV. Difluoro(trimethylsilyl)acetonitrile: Synthesis and Fluoroalkylation Reactions[J]. The Journal of Organic Chemistry, 2012, 77 13: 5850-5855. DOI:10.1021/jo301094b.
    [2] YANCHUAN ZHAO. Efficient and Direct Nucleophilic Difluoromethylation of Carbonyl Compounds and Imines with Me3SiCF2H at Ambient or Low Temperature[J]. Organic Letters, 2011, 13 19: 5342-5345. DOI:10.1021/ol202208b.
    [3] PATRICK S. FIER  John F H. Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides[J]. Journal of the American Chemical Society, 2012, 134 12: 5524-5527. DOI:10.1021/ja301013h.
(Difluoromethyl)trimethylsilane Preparation Products And Raw materials
Raw materials
Preparation Products
(Difluoromethyl)trimethylsilane Suppliers
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(Difluoromethyl)trimethylsilane Spectrum
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