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TriMethyl(broModifluoroMethyl)silane

CAS No.115262-01-6
Chemical Name:TriMethyl(broModifluoroMethyl)silane
CBNumber:CB02611493
Molecular Formula:C4H9BrF2Si
Formula Weight:203.1
MOL File:115262-01-6.mol

TriMethyl(broModifluoroMethyl)silane Property

Boiling point 108°C(lit.)
Density 1.306
refractive index n/D1.407
Flash point 46℃
storage temp. -20°C
form liquid
color clear
InChIKey WDZVWBWAUSUTTO-UHFFFAOYSA-N
CAS DataBase Reference 115262-01-6
UNSPSC Code 12352101
NACRES NA.22

Safety

Risk Statements :11
Safety Statements :24/25
RIDADR :UN 1993C 3 / PGIII
TSCA :No
HazardClass :3
PackingGroup :II
HS Code :29319090

NFPA 704:

	4
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H226-H315-H319-H335
Precautionary statements P210-P302+P352-P305+P351+P338

TriMethyl(broModifluoroMethyl)silane Price More Price(3)

Brand: Sigma-Aldrich(India)
Product number: 808601
Product name : (Bromodifluoromethyl)trimethylsilane
Purity: 98%
Packaging: 1G
Price: ₹13509.6
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: B4325
Product name : (Bromodifluoromethyl)trimethylsilane
Purity: min. 98.0 %
Packaging: 1G
Price: ₹10200
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: B4325
Product name : (Bromodifluoromethyl)trimethylsilane
Purity: min. 98.0 %
Packaging: 5G
Price: ₹19300
Updated: 2022/05/26
Buy: Buy

TriMethyl(broModifluoroMethyl)silane Chemical Properties,Usage,Production

Chemical Properties Colorless transparent liquid, initial boiling point 108℃, relative density 1.31 g/cm³.
Uses Novel difluorocarbene source for the efficient difluoromethylenation of alkenes/alkynes and difluoromethylation of O-, S-, and N-nucleophiles.
Uses Trimethyl(bromodifluoromethyl)silane can be used as neuroactive steroids.
Uses As reported by Hu and co-workers, (Bromodifluoromethyl)trimethylsilane is a highly useful reagent for the formation of difluoromethene-containing 3-membered rings and can also difluoromethylate heteroatoms with the assistance of alkaline bases, most effectively KOH.
Application
- TriMethyl(broModifluoroMethyl)silane commonly can be used as a source for generating difluorocarbene, it is a general reagent with broad synthetic utility.
- Can generate difluorocarbene under neutral/acidic/basic conditions in the presence/absence of water at low/high temperatures.
- Can be used to prepare gem-difluorocyclopropan(e)nes, O-, S-, N-, and P-difluoromethylated compounds
Reactions (1) Difluoromethylenation of TMSCN.

Ref. J. Org. Chem. 2012, 77, 5850?5855.
(2) Difluoromethylenation of benzyl and alkylzinc halides.

Ref. Org. Lett. 2013, 15, 917 – 919.
(3) Fluorination aminocarbonylation of aldehydes

Ref. Angew. Chem. Int. Ed. 2022, e202115467
General Description (Bromodifluoromethyl)trimethylsilane (TMSCF₂Br) is commonly used as a source to generate dilfluorocarbene. TMSCF₃ (Ruppert–Prakash reagent) and BBr₃ undergoes fast halogen–exchange reaction to form MSCF₂Br.
References [1]Angewandte Chemie International Edition.DOI :10.1002/anie.202283811
[2]The Journal of Organic Chemistry.DOI :10.1021/acs.orglett.2c02899