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PIPERLONGUMINE

PIPERLONGUMINE Structure
PIPERLONGUMINE
  • CAS No.20069-09-4
  • Chemical Name:PIPERLONGUMINE
  • CBNumber:CB7246450
  • Molecular Formula:C17H19NO5
  • Formula Weight:317.34
  • MOL File:20069-09-4.mol
PIPERLONGUMINE Property
  • Melting point 124°C
  • Boiling point 475.6±45.0 °C(Predicted)
  • Density 1.223±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: ≥5mg/mL at warmed to 60°C
  • pka -1.88±0.20(Predicted)
  • form powder
  • color white to beige
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
  • LogP 2.340 (est)
  • FDA UNII SGD66V4SVJ
  • UNSPSC Code 51111800
  • NACRES NA.77
Safety
  • WGK Germany  :3
  • RTECS  :UU7785850
  • HS Code  :2932209090
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H320-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338
PIPERLONGUMINE Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0221
  • Product name : Piperlongumine
  • Purity: ≥97% (HPLC)
  • Packaging: 5MG
  • Price: ₹12925.05
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0221
  • Product name : Piperlongumine
  • Purity: ≥97% (HPLC)
  • Packaging: 25MG
  • Price: ₹52133.2
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 528124
  • Product name : Piperlongumine - CAS 20069-09-4 - Calbiochem
  • Purity: A cell-permeable, orally bioavailable natural product isolated from the plant species, Piper longum L, which selectively induces cell death in cancer
  • Packaging: 25MG
  • Price: ₹8310
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: P2361
  • Product name : Piperlongumine
  • Purity: 
  • Packaging: 25MG
  • Price: ₹9200
  • Updated: 2022/05/26
  • Buy: Buy

PIPERLONGUMINE Chemical Properties,Usage,Production

  • Description A piperidinone alkaloid present in Piper longum, the structure has been shown to be N-(3:4:5-trimethoxycinnamoyl)-Lls-piperidin-2-one. In the plant, the base occurs mainly in the roots.
  • Uses anti-asthma, antibronchitis
  • Uses Piperlongumine has been used to study the regulation of protein regulator of cytokinesis 1 (PRC1) expression. It has also been used to investigate its anti-tumor effects on human melanoma cells in vitro.
  • Uses Piperlongumine (PL), a new alkaloid abundantly present in Piper longum fruits strongly inhibited platelet cell aggregation. It may have anti-cancer properties. It selectively targets and kills cancer cells but leaving normal cells unharmed.
  • Definition ChEBI: Piplartine is a member of cinnamamides and a dicarboximide.
  • General Description Piperlongumine is an alkaloid, which is extracted from Piper longum Linn. It exhibits anti-atherosclerotic, anxiolytic, antidiabetic, antidepressant, antibacterial, anti-platelet, aggregation, anxiolytic and anti-inflammatory properties. Piperlongumine prevents the production of tumor necrosis factor-α and interleukin-6. It blocks the activation of nuclear factor-κB (NF-κB) against proinflammatory responses. Piperlongumine inhibits plaque formation and inhibits vascular smooth muscle cell migration. It is used to treat cough, respiratory infections and stomach-ache.
  • Biochem/physiol Actions Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). It increases the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells with little effect on either rapidly or slowly dividing primary normal cells. Piperlongumine showed significant antitumour effects in a variety of mouse tumour models and inhibited growth of spontaneously formed malignant breast tumours and their associated metastases.
  • target P450 (e.g. CYP17) | Antifection
  • References Chatterjee, Dutta., Tetrahedron, 23, 1769 (1967)
PIPERLONGUMINE Preparation Products And Raw materials
Raw materials
Preparation Products
PIPERLONGUMINE Suppliers
Global(252)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29858
  • Advantage：58
  • Supplier：
    Biochempartner
  • Tel：0086-13720134139
  • Email：candy@biochempartner.com
  • Country：CHINA
  • ProdList：965
  • Advantage：58
PIPERLONGUMINE Spectrum
20069-09-4, PIPERLONGUMINERelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Aromatics
  • 生物碱类
  • 医用原料
  • 抑制剂
  • 配体家族
  • 高端化学
  • 医药原料
  • 标准品
  • 对照品
  • 标准品，对照品
  • 标准品 -中药标准品
  • 生物碱
  • 对照品
  • 植物提取物
  • 合成
  • Pyridines
  • Heterocyclic Building Blocks
  • C9 to C46
  • Building Blocks
  • C17H19NO5
  • 20069-09-0
  • 荜茇酰胺,10 MM DMSO 溶液
  • PIPERLONGUMINE,ALKALOID FROM PIPER LONGUM L.
  • 荜茇酰胺/HPLC
  • 荜鲃酰胺
  • 荜拨明宁碱(荜茇酰胺)
  • (E)-1-(3-(3,4,5-三甲氧基苯基)丙烯酰基)-5,6-二氢吡啶-2(1H)-酮
  • PIPERLONGUMINE 荜茇酰胺
  • 荜茇酰胺
  • 荜拨明宁碱
  • 3,4,5-三甲氧基肉桂酰环己酰胺(荜芨酰胺)
  • 20069-09-4
  • Piperlongumine, 10 mM in DMSO
  • Piperlongumine, alkaloid from Piper longum L.
  • PIPERLONGUMINE98%
  • Piperlorgumia
  • Piperlorgumine (natural )
  • Piplartine powder
  • ongumine
  • 2(1H)-Pyridinone, 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-
  • Piperlangamine
  • umine
  • PiperL
  • ong
  • Piperlongumine - CAS 20069-09-4 - Calbiochem
  • Piperlongumine - Piplartine
  • PIPERLONGUMINE(P)
  • Piplartin
  • 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-triMethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone
  • 5,6-Dihydro-1-(3,4,5-triMethoxycinnaMoyl)-2(1H)-pyridone
  • (E)-5,6-Dihydro-1-[1-oxo-3-(3,4,5-triMethoxyphenyl)-2-propenyl]-2(1H)-pyridinone
  • 5,6-dihydro-1-[1-oxo-3-(3,4,5-triMethoxyphenyl)-allyl]-2(1H)-pyridinone
  • (E)-1-(3-(3,4,5-TRIMETHOXYPHENYL)ACRYLOYL)PIPERIDIN-2-ONE
  • 5,6-Dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]pyridin-2(1H)-one
  • acryloyl)

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