ChemicalBook CAS DataBase List 20069-09-4

20069-09-4

Name	PIPERLONGUMINE
CAS	20069-09-4
Molecular Formula	C17H19NO5
MDL Number	MFCD00075706
Molecular Weight	317.34
MOL File	20069-09-4.mol

Chemical Properties

Melting point	124°C
Boiling point	475.6±45.0 °C(Predicted)
density	1.223±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥5mg/mL at warmed to 60°C
form	powder
pka	-1.88±0.20(Predicted)
color	white to beige
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
LogP	2.340 (est)

Safety Data

WGK Germany	3
RTECS	UU7785850
HS Code	2932209090

Hazard Information

Description

A piperidinone alkaloid present in Piper longum, the structure has been shown to be N-(3:4:5-trimethoxycinnamoyl)-Lls-piperidin-2-one. In the plant, the base occurs mainly in the roots.

Uses

anti-asthma, antibronchitis

Uses

Piperlongumine (PL), a new alkaloid abundantly present in Piper longum fruits strongly inhibited platelet cell aggregation. It may have anti-cancer properties. It selectively targets and kills cancer cells but leaving normal cells unharmed.

Definition

ChEBI: Piplartine is a member of cinnamamides and a dicarboximide.

General Description

Piperlongumine is an alkaloid, which is extracted from Piper longum Linn. It exhibits anti-atherosclerotic, anxiolytic, antidiabetic, antidepressant, antibacterial, anti-platelet, aggregation, anxiolytic and anti-inflammatory properties. Piperlongumine prevents the production of tumor necrosis factor-α and interleukin-6. It blocks the activation of nuclear factor-κB (NF-κB) against proinflammatory responses. Piperlongumine inhibits plaque formation and inhibits vascular smooth muscle cell migration. It is used to treat cough, respiratory infections and stomach-ache.

Biochem/physiol Actions

Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). It increases the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells with little effect on either rapidly or slowly dividing primary normal cells. Piperlongumine showed significant antitumour effects in a variety of mouse tumour models and inhibited growth of spontaneously formed malignant breast tumours and their associated metastases.

target

P450 (e.g. CYP17) | Antifection

References

Chatterjee, Dutta., Tetrahedron, 23, 1769 (1967)

Spectrum Detail

Supplier

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Telephone 15229059051

Websitehttp://www.dideu.cn

Shanghai Boyle Chemical Co., Ltd.

Telephone

Websitehttp://www.boylechem.com

J & K SCIENTIFIC LTD.

Telephone010-82848833 400-666-7788

Websitehttp://www.jkchemical.com

Meryer (Shanghai) Chemical Technology Co., Ltd.

Telephone021-61259108 18621169109

Websitehttps://www.meryer.com/cn/index/

TCI (Shanghai) Development Co., Ltd.

Telephone021-67121386

Websitehttps://www.tcichemicals.com/CN/zh/

JinYan Chemicals(ShangHai) Co.,Ltd.

Telephone13817811078

Websitehttp://www.jingyan-chemical.com/

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

Chemsky (shanghai) International Co.,Ltd

Telephone021-50135380

Websitehttp://www.shchemsky.com

Dalian Meilun Biotech Co., Ltd.

Telephone0411-62910999 13889544652

Websitehttp://www.meilune.com/

Shanghai Hope Chem Co., Ltd.，

Telephone+21-18501659228 18501659228

Websitehttp://www.hope-chem.com

BioBioPha Co., Ltd.

Telephone0871-65217109 13211707573;

Websitehttp://www.biobiopha.com

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Telephone400-400-6206333 18521732826

Websitehttp://www.aladdin-e.com/

Shanghai Tauto Biotech Co., Ltd.

Telephone021-51320588

Websitehttp://www.tautobiotech.com/

TargetMol Chemicals Inc.

Telephone021-021-33632979 15002134094

Websitehttps://www.targetmol.cn/

Shanghai TaoSu Biochemical Technology Co., Ltd.

Telephone021-33632979

Websitehttp://www.tsbiochem.com

Shanghai Huikai Chemical Technology Co., Ltd.

Telephone021-61995394 18916691159

Websitehttp://www.chemicalsea.com

ShangHai Caerulum Pharma Discovery Co., Ltd.

Telephone18149758185 18149758185

Websitehttp://www.caerulumpharma.com

Bide Pharmatech Ltd.

Telephone400-164-7117 13681763483

Websitehttp://www.bidepharm.com

1of4

Related Products

Send Inquriy