Brand Name(s) in US
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Ticarcillin

Brand Name(s) in US
Ticarcillin Structure
Ticarcillin
  • CAS No.34787-01-4
  • Chemical Name:Ticarcillin
  • CBNumber:CB7224768
  • Molecular Formula:C15H16N2O6S2
  • Formula Weight:384.43
  • MOL File:34787-01-4.mol
Ticarcillin Property
  • Boiling point 768.3±60.0 °C(Predicted)
  • Density 1.62±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • pka pKa 2.89±0.05(H2O t=25.0 I=0.15 (KCl)) (Uncertain);3.28±0.04 (Uncertain)
  • CAS DataBase Reference 34787-01-4(CAS DataBase Reference)
  • FDA UNII F93UJX4SWT
  • ATC code J01CA13
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :42/43
  • Safety Statements  :22-36/37-45
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H317-H334
  • Precautionary statements P261-P280-P342+P311

Ticarcillin Chemical Properties,Usage,Production

  • Brand Name(s) in US Timentin
  • Description Temocillin disodium is a broad-spectrum, β-lactamase resistant, injectable penicillin. High serum levels and a five hour half-life allow once or twice-daily dosing.
  • Originator Beecham (United Kingdom)
  • Uses Ticarcillin is a carboxypenicillin belonging to the beta-lactam class of antibiotics. Ticarcillin is an injectable antibiotic used in the treatment of infections caused by gram-negative bacteria, particularly Pseudomonas aeruginosa.
  • Uses Ticarcillin (SB) is a significant penicillin antibiotic that incorporates the thiophene ring system.
  • Definition ChEBI: A penicillin compound having a 6beta-[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino side-group.
  • brand name TEMOPEN
  • Antimicrobial activity Because it is hydrolyzed less rapidly than ampicillin, non-β- lactamase-producing strains of N. gonorrhoeae, ampicillin-susceptible H. influenzae and some Enterobacteriaceae are susceptible. Most aerobic and anaerobic Gram-positive bacteria are susceptible, with the exception of E. faecalis and β-lactamase-producing Staph. aureus. Anaerobic Gram-negative bacteria including B. fragilis are usually susceptible. Bactericidal synergy with aminoglycosides is demonstrable against Ps. aeruginosa and enterobacteria.
  • Acquired resistance Ticarcillin is generally cross-resistant with carbenicillin. It is somewhat stable to hydrolysis by AmpC-mediated β-lactamases of Gram-negative bacilli, but can be hydrolyzed by most other chromosomally and plasmid-mediated enzymes unless protected by a β-lactamase inhibitor.
  • Pharmacokinetics Oral absorption: Negligible
    Cmax 1 g intramuscular: 35 mg/L after 1 h
    Plasma half-life: 1.3 h
    Volume of distribution: 0.21 L/kg
    Plasma protein binding: 50–60%
    Absorption and distribution
    It is not orally absorbed. On parenteral co-administration with gentamicin, the plasma concentration of ticarcillin is unaffected, but the concentration of gentamicin is lowered. It enters the serous fluids, providing concentrations up to 60% of those of the plasma. It does not cross the normal meninges but levels of up to 50% of those of the plasma can be found in meningitis.
    Metabolism and excretion
    Up to 15% is excreted as penicilloic acid, a higher percentage than for carbenicillin (up to 5%). Some is excreted in the bile, producing levels 2–3 times those in the plasma, but the main route of excretion is through the kidneys (80%), principally as unchanged drug, appearing in the urine in the first 6 h. It is more rapidly eliminated in children with cystic fibrosis.
  • Clinical Use Serious infection, including septicemia, respiratory tract infections, genitourinary tract infections and skin and soft-tissue infections caused by susceptible bacteria
  • Side effects As with all penicillins, hypersensitivity reactions may occur, but are less frequent and severe than those associated with benzylpenicillin. Rashes and eosinophilia occur; reversible abnormalities of liver function can develop. Since large doses of the drug have to be used, convulsions can occur, as with other penicillins, and being a disodium salt, electrolyte disturbances can result from the sodium load and from loss of potassium.
  • Synthesis Ticarcillin, [2S-(2|á,5|á,6|?)]-3,3-dimethyl-7-oxo-6-[2-carboxy-2-(3-thienyl) acetamido]-4-thia-1-azabicyclo[3.2.0]-heptan-2-carboxylic acid (32.1.1.34), is synthesized by direct acylation of 6-APA in the presence of sodium hydroxide, but with 3-thienylmalonic acid chloride (32.1.1.33), which gives ticarcillin.

    Synthesis_34787-01-4

Ticarcillin Preparation Products And Raw materials
Raw materials
Preparation Products
Ticarcillin Suppliers
Global(84)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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  • Advantage：58
  • Supplier：
    Career Henan Chemica Co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：laboratory@coreychem.com
  • Country：China
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  • Advantage：58
  • Supplier：
    GIHI CHEMICALS CO.,LIMITED
  • Tel： +8618058761490
  • Email：info@gihichemicals.com
  • Country：China
  • ProdList：49984
  • Advantage：58
Ticarcillin Spectrum
34787-01-4, TicarcillinRelated Search:
  • 杂质对照品
  • 氨基糖苷类抗生素
  • BioChemical
  • Media
  • Microbiology
  • Supplements
  • C15H16N2O6S2
  • 替卡西林杂质11
  • 化合物 T20115
  • 替卡西林酸
  • 替卡西林添加剂
  • 羧噻吩青霉素
  • 替卡西林
  • (2S,5R,6R)-3,3-二甲基-6-[2-羧基-2-(2-噻吩基)乙酰氨基]-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-羧酸
  • 替卡西林(需办证)
  • 34787-01-4
  • Ticarcillin Impurity 11
  • icarcillin
  • Ticarcillin free base
  • Ticarcillin DISCONTINUED. Please see T437901
  • Ticarcillin USP/EP/BP
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-carboxy-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
  • disodium (2S,5R,6R)-6-[[(2R)-2-carboxylato-1-oxo-2-(3-thiophenyl)ethyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • Ticarcillin See T437901
  • Temocillin Disodium
  • Ticcarcillin acid
  • TICARCILLIN
  • Ticarcillin Supplement,Ticarcillin
  • Ticarcillin acid
  • 6-[D-(-)-a-Carboxy-3-thienylacetamido]penicillanic acid
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- (9CI)
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(carboxy-3-thienylacetyl)amino]-3,3-dimethyl-7-oxo-, [2S-[2a,5a,6b(S*)]]-
  • TRIARCILLIN
  • (2s,5r,6r)-6-[[(2r)-2-carboxy-2-thiophen-3-yl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

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