Brand Name(s) in US
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Ticarcillin disodium salt

Brand Name(s) in US
Ticarcillin disodium salt Structure
Ticarcillin disodium salt
  • CAS No.4697-14-7
  • Chemical Name:Ticarcillin disodium salt
  • CBNumber:CB3147339
  • Molecular Formula:C15H17N2NaO6S2
  • Formula Weight:408.42
  • MOL File:4697-14-7.mol
Ticarcillin disodium salt Property
  • Melting point >173°C (dec.)
  • storage temp. 2-8°C
  • solubility H2O: soluble50mg/mL
  • form powder
  • color white to light yellow
  • Merck 13,9505
  • Stability Moisture sensitive
  • InChIKey ZBBCUBMBMZNEME-QBGWIPKPSA-L
  • CAS DataBase Reference 4697-14-7(CAS DataBase Reference)
  • FDA UNII G8TVV6DSYG
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H315-H319-H334-H335
  • Precautionary statements P302+P352-P305+P351+P338
Ticarcillin disodium salt Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: T5639
  • Product name : Ticarcillin disodium salt
  • Purity: 
  • Packaging: 1G
  • Price: ₹18250.95
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: SRL
  • Product number: 53073
  • Product name : Ticarcillin Disodium Salt extrapure, 85%, Endotoxin (BET) 0.05EU/mg
  • Purity: 
  • Packaging: 1Gms
  • Price: ₹1950
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: SRL
  • Product number: 53073
  • Product name : Ticarcillin Disodium Salt extrapure, 85%, Endotoxin (BET) 0.05EU/mg
  • Purity: 
  • Packaging: 5Gms
  • Price: ₹8860
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: ottokemi
  • Product number:  T 6353
  • Product name : Ticarcillin disodium salt ≥95%
  • Purity: 95%
  • Packaging: 1gm
  • Price: ₹15039
  • Updated: 2022/05/26
  • Buy: Buy

Ticarcillin disodium salt Chemical Properties,Usage,Production

  • Brand Name(s) in US Ticar, Ticillin
  • Description Ticarcillin is a semisynthetic β-lactam antibiotic. It is active against P. aeruginosa, E. coli, P. mirabilis, P. rettgeri, and K. aerogenes (MICs = 4-125 μg/ml). Topical administration of ticarcillin (2.5 mg per eye) reduces P. aeruginosa colony count in rabbit eye. Formulations containing ticarcillin have been used in the treatment of a variety of bacterial infections.
  • Chemical Properties Ticarcillin disodium salt is White Solid
  • Originator Ticar,Beecham,US,1976
  • Uses coccidiostat
  • Uses The disodium salt of Ticarcillin, a carboxypenicillin belonging to the beta-lactam class of antibiotics. Ticarcillin is an injectable antibiotic used in the treatment of infections caused by gram-negative bacteria, particularly Pseudomonas aeruginosa.
  • Definition ChEBI: Ticarcillin disodium is an organic sodium salt. It contains a ticarcillin(2-).
  • Manufacturing Process A mixture of monobenzyl-3-thienylmalonate (1.38 g, 5 mmol) and thionyl chloride (2.5 ml) was warmed at 50°C to 55°C for 1 hour, then at 60°C to 65°C for 10 minutes. The excess of thionyl chloride was removed in vacuo at not more than 30°C, the last traces being removed by codistillation with dry benzene (1 ml) under high vacuum, leaving monobenzyl3-thienylmalonyl chloride as a yellow oil.
    The acid chloride obtained as described above was dissolved in dry acetone (10 ml) and added in a steady stream to a stirred solution of 6- aminopenicillanic acid (1.08 g, 5 mmol) in a mixture of N sodium bicarbonate (15 ml) and acetone (5 ml). After the initial reaction the reaction mixture was stirred at room temperature for 45 minutes, then washed with ether (3 x 25 ml). Acidification of the aqueous solution with N hydrochloric acid (11 ml) to pH 2 and extraction with ether (3 x 15 ml) gave an ethereal extract which was decolorized with a mixture of activated charcoal and magnesium sulfate for 5 minutes.
    The resulting pale yellow ethereal solution was shaken with sufficient N sodium bicarbonate (4 ml) to give an aqueous extract of pH 7 to 7.5. This extract was concentrated to syrup at low temperature and pressure, then isopropanol was added with stirring until the mixture contained about 10% water.
    Crystallization was initiated, and completed at about 0°C overnight, to give the sodium salt of α-(benzyloxycarbonyl)-3-thienylmethylpenicillin as white crystals in 50% weight yield. This product was estimated by colorimetric assay with hydroxylamine to contain 91% of the anhydrous sodium salt. A solution of the sodium salt of α-(benzyloxycarbonyl)-3- thienylmethylpenicillin (2.13 g, 4.3 mmol) in water (30 ml) was added to a suspension of 5% palladium on calcium carbonate (10.65 g) in water (32 ml) which had been prehydrogenated for 1 hour.
    The mixture was then hydrogenated at just above atmospheric pressure for 1 1/2 hours and filtered through a Dicalite bed. The clear filtrate was evaporated at low temperature and pressure, and the residue dried in vacuo over phosphorus pentoxide, to give 1.64 g of the salt of α-(3- thienyl)methylpenicillin as a white solid. Colorimetric assay with hydroxylamine showed this salt to contain 94% of the anhydrous penicillin. Paper chromatography showed complete reduction of the benzyl group.
  • Therapeutic Function Antibiotic
  • General Description Ticarcillin was synthesized by Beecham Research Laboratories in 1971. The phenyl residue of carbenicillin was replaced by the 3-thienyl moiety. Ticarcillin shows almost the same activity as carbenicillin against gram-positive bacteria and a twofold higher activity against gram-negative bacteria. Its in vivo activity against Pseudomonas aeruginosa infections in mice is fourfold higher than that of sulbenicillin. Ticarcillin is used to treat sepsis, urinary tract infections, and serious Pseudomonas aeruginosa, Escherichia coli, Proteus, and Enterobacter infections in leukemic and other cancer patients.
Ticarcillin disodium salt Preparation Products And Raw materials
Raw materials
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Ticarcillin disodium salt Spectrum
4697-14-7, Ticarcillin disodium saltRelated Search:
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  • C15H14N2O6S2Na2
  • C15H14N2Na2O6S2
  • C15H14N2O6S22Na
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  • 特美丁(新型革兰氏阴性菌抗生索)
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  • 替卡西林钠 EP标准品
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  • TIMENTIN特美汀(新型革兰氏阴性菌抗生素)
  • 特美汀(新型革兰氏阴性菌抗生素)
  • 替莫西林二钠盐
  • (2S,5R,6R)-6-[[(2R)-羧基-3-噻吩基乙酰]氨基]-3,3-二甲基-7-氧代-4-硫杂-1-氮杂二环[3.2.0]庚烷-2-羧酸二钠盐
  • 替卡西林钠
  • 替卡西林二钠
  • [2S-[2Α,5Α,6Β(S^<*>^)]]-6-[(羧基-3-噻吩乙酰基)氨基]-3,3-二甲基-7-氧代-4-硫-1-氮杂双环[3.2.0]庚烷-2-羧酸二钠盐
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  • 4697-14-7
  • Disodium (2S,5R,6R)-6-(2-carboxylato-2-(thiophen-3-yl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
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