ChemicalBook > CAS DataBase List > H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Structure
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
  • CAS No.117399-93-6
  • Chemical Name:H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
  • CBNumber:CB7181630
  • Molecular Formula:C121H168N26O33S4
  • Formula Weight:2643.04
  • MOL File:117399-93-6.mol
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Property
  • Density 1.285±0.06 g/cm3(Predicted)
  • storage temp. −20°C
  • solubility 5% acetic acid: 0.5mg/mL
  • form powder
  • color white
  • biological source rabbit
  • Water Solubility Soluble to 1 mg/ml in water
  • FDA UNII 0066WLJ02E
  • UNSPSC Code 12352203
  • NACRES NA.77
Safety
  • Safety Statements  :22
  • WGK Germany  :3
  • F  :3-10
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300+H330
  • Precautionary statements P301+P310+P330-P304+P340+P310
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: E9137
  • Product name : Endothelin 3 human, rat
  • Purity: ≥97% (HPLC), powder
  • Packaging: 10μG
  • Price: ₹12632.78
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: E9137
  • Product name : Endothelin 3 human, rat
  • Purity: ≥97% (HPLC), powder
  • Packaging: 50μG
  • Price: ₹36014.78
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: E9137
  • Product name : Endothelin 3 human, rat
  • Purity: ≥97% (HPLC), powder
  • Packaging: 0.1MG
  • Price: ₹62319.53
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 05-23-3801
  • Product name : Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem
  • Purity: Attenuates thrombin-evoked aggregation of human platelets.
  • Packaging: .5MG
  • Price: ₹47630
  • Updated: 2022/06/14
  • Buy: Buy

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Chemical Properties,Usage,Production

  • Uses Endothelin 3 human, rat has been used for culturing neural tube explant culture, and the pharmacological study of endothelin receptors.
  • General Description Endothelin 3 (ET3) belongs to endothelin peptide family, which includes three members, ET-1, -2 and -3. These are 21-amino acid peptides, which are synthesized as precursors. They are converted to biologically active peptides, after being cleaved by proteases. There are two endothelin receptors called ETRA and ETRB, and ET3 binds to ETRB. It is localized to human intestine and colon.
  • Biochem/physiol Actions Endothelin 3 (ET3) is a vasoconstrictor that acts in a paracrine and autocrine manner, and in intestinal lamina propria causes the degranulation of mast cells. It results in the release of ions from intestinal epithelial cells. In acute and chronic intestinal inflammation, it is overexpressed. It is also up-regulated in colon carcinoma, where it supports cell proliferation and survival. It might be involved in colon homeostasis, and is essential for the survival and proliferation of goblet cells. In mice, it is essential for the development of pigment cells derived from neural crest (NC). Its expression is de-regulated in metastatic melanoma.
  • in vivo

    Endothelin-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and NO production. Endothelin-3, which acts mainly on ETB, at low concentrations specifically inhibited platelet-activating factor (PAF)-induced paw oedema, whereas neither ET-1 nor Endothelin-2, both of which act on ETA and ETB, showed inhibitory activity. The inhibition by ET-1 and Endothelin-3 (each 0.5 pmol/paw) in the presence of BQ-123 (66.4 ± 6.7 % and 65.4 ± 22.6 %, respectively), is comparable to that by Endothelin-3 (0.5 pmol/paw) alone (65.4 ± 10.9 %), whereas neither ET-1 nor Endothelin-3 in the presence of BQ-788 showed inhibitory activity[3].

  • storage Store at -20°C
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Preparation Products And Raw materials
Raw materials
Preparation Products
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Suppliers
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H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Spectrum
117399-93-6, H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OHRelated Search:
  • Endothelin receptor
  • Peptide
  • 抑制剂
  • 药靶配体
  • 多肽
  • 目录肽
  • 目录多肽
  • 细胞信号和神经生物学
  • 细胞生物学
  • Endothelins
  • Peptides
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • BioChemical
  • Agonist
  • C121H168N26O33S4
  • ENDOTHELIN 3 (RAT,HUMAN)|CAS 117399-93-6
  • 化合物 ENDOTHELIN-3, HUMAN, MOUSE, RABBIT, RAT
  • 内皮素 3 人,大鼠,三氟乙酸盐
  • 内皮素-3
  • 人内皮素3, ≥97% (HPLC), POWDER
  • 人内皮素3
  • 小鼠内皮素-3
  • 117399-93-6
  • (3S)-3-[[(2S)-2-[[(2S)-2-[[(1R,4S,7S,10S,13S,16S,19S,22S,25R,28S,31R,36R,39S,42S,45S)-31-amino-7,13-bis(4-aminobutyl)-22-benzyl-4-(2 -carboxyethyl)-10-(carboxymethyl)-19,28-bis[(1R)-1-hydroxyethyl]-16,39,42-tris[(4-hydroxyphenyl)methyl]-3,6,9,12,15,18,21,
  • Endothelin 3, human, rat, mouse, rabbit
  • CAS:117399-93-6
  • Human endothelin-3/Rat endothelin-3
  • Endothelin 3 human, rat (TFA)
  • H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH USP/EP/BP
  • L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide)
  • Endothelin 3 (Rat,Human)
  • Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem
  • Endothelin 3, human, rat, ≥97% (HPLC), powder
  • ENDOTHELIN 3, HUMAN, RAT, 50 UG*
  • Rat endothelin-3
  • Human endothelin-3
  • Endothelin 3 (mouse intestine)
  • 33,34,49,50-Tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacontane, cyclic peptide deriv.
  • 19: PN: WO2007112069 SEQID: 10 claimed protein
  • ANTI-EDN3 (C-TERM) antibody produced in rabbit
  • HSCR4
  • EDN3
  • Anti-EDN3 antibody produced in rabbit
  • Endothelin 3 (huMan)(9CI)
  • Endothelin 3 huMan, ratEndothelin
  • Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11)
  • Endothelin-3 (huMan, Mouse, rabbit, rat) ET-3 (huMan, Mouse, rabbit, rat)
  • CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP: CTCFTYKDKECVYYCHLDIIW DISULFIDE BRIDGES CYS1-CYS15, CYS3-CYS11
  • CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR- TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP(DISULFIDE BRIDGE:CYS1-CYS15, CYS3-CYS11)
  • Endothelin 3【rat】
  • Endothelin 3【rabbit】
  • Endothelin 3【canine】
  • M.W. 2643.04 C121H168N26O33S4
  • et-3
  • human,rat
  • ET-3 (HUMAN, RAT, PIG)
  • ET-3 (HUMAN, RAT)

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