ChemicalBook CAS DataBase List 117399-93-6

117399-93-6

Name	H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
CAS	117399-93-6
Molecular Formula	C121H168N26O33S4
MDL Number	MFCD00076378
Molecular Weight	2643.04
MOL File	117399-93-6.mol

Synonyms

et-3 EDN3 HSCR4 human,rat ET-3, HUMAN ENDOTHELIN-3 Rat endothelin-3 ET-3 (HUMAN, RAT) Endothelin 3【rat】 Human endothelin-3 ET-3, HUMAN AND RAT ENDOTHELIN-3, HUMAN Endothelin 3【canine】 Endothelin 3【rabbit】 CTCFTYKDKECVYYCHLDIIW ET-3 (HUMAN, RAT, PIG) ENDOTHELIN 3 HUMAN, RAT Endothelin 3 (Rat,Human) Endothelin 3 (huMan)(9CI) ENDOTHELIN-III, HUMAN, RAT ENDOTHELIN 3, HUMAN AND RAT ENDOTHELIN-3 (HUMAN, RAT, PIG) Endothelin 3 (mouse intestine) ENDOTHELIN 3, HUMAN, RAT, 50 UG* ET-3 (HUMAN, MOUSE, RABBIT, RAT) M.W. 2643.04 C121H168N26O33S4 Endothelin 3 huMan, ratEndothelin Anti-EDN3 antibody produced in rabbit ENDOTHELIN-3 (HUMAN, MOUSE, RABBIT, RAT) ENDOTHELIN-3 (HUMAN, RAT, PORCINE, RABBIT) ENDOTHELIN-3 (HUMAN) (PORCINE, RAT, RABBIT) Endothelin 3, human, rat, ≥97% (HPLC), powder ANTI-EDN3 (C-TERM) antibody produced in rabbit 19: PN: WO2007112069 SEQID: 10 claimed protein CTCFTYKDKECVYYCHLDIIW (DISULFIDE BRIDGE: 1-15 AND 3-11) Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem Endothelin-3 (huMan, Mouse, rabbit, rat) ET-3 (huMan, Mouse, rabbit, rat) CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH USP/EP/BP CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP HUMAN, RAT, PORCINE, RABBIT H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11) CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR- TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP(DISULFIDE BRIDGE:CYS1-CYS15, CYS3-CYS11) 33,34,49,50-Tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacontane, cyclic peptide deriv. Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11) CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP: CTCFTYKDKECVYYCHLDIIW DISULFIDE BRIDGES CYS1-CYS15, CYS3-CYS11 L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide)

Chemical Properties

density	1.285±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	H2OPeptide Solubility and Storage Guidelines:1.??Calculate the length of the peptide.2.??Calculate the overall charge of the entire peptide according to the following table:3.??Recommended solution:
form	powder
color	white
biological source	rabbit
Water Solubility	Soluble to 1 mg/ml in water
Sequence	Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp(Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
InChIKey	OQGZWNZGVYLIFX-XKIQDWPYSA-N

Safety Data

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H300+H330
Precautionary statements	P301+P310+P330-P304+P340+P310
Safety Statements	22 less more
WGK Germany	3
F	3-10
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials

Hazard Information

Uses

Endothelin 3 human, rat has been used for culturing neural tube explant culture, and the pharmacological study of endothelin receptors.

General Description

Endothelin 3 (ET3) belongs to endothelin peptide family, which includes three members, ET-1, -2 and -3. These are 21-amino acid peptides, which are synthesized as precursors. They are converted to biologically active peptides, after being cleaved by proteases. There are two endothelin receptors called ETRA and ETRB, and ET3 binds to ETRB. It is localized to human intestine and colon.

Biochem/physiol Actions

Endothelin 3 (ET3) is a vasoconstrictor that acts in a paracrine and autocrine manner, and in intestinal lamina propria causes the degranulation of mast cells. It results in the release of ions from intestinal epithelial cells. In acute and chronic intestinal inflammation, it is overexpressed. It is also up-regulated in colon carcinoma, where it supports cell proliferation and survival. It might be involved in colon homeostasis, and is essential for the survival and proliferation of goblet cells. In mice, it is essential for the development of pigment cells derived from neural crest (NC). Its expression is de-regulated in metastatic melanoma.

in vivo

Endothelin-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and NO production. Endothelin-3, which acts mainly on ETB, at low concentrations specifically inhibited platelet-activating factor (PAF)-induced paw oedema, whereas neither ET-1 nor Endothelin-2, both of which act on ETA and ETB, showed inhibitory activity. The inhibition by ET-1 and Endothelin-3 (each 0.5 pmol/paw) in the presence of BQ-123 (66.4 ± 6.7 % and 65.4 ± 22.6 %, respectively), is comparable to that by Endothelin-3 (0.5 pmol/paw) alone (65.4 ± 10.9 %), whereas neither ET-1 nor Endothelin-3 in the presence of BQ-788 showed inhibitory activity^[3].

storage

Store at -20°C

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