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Isobutyl chloroformate

CAS No.543-27-1
Chemical Name:Isobutyl chloroformate
CBNumber:CB7165612
Molecular Formula:C5H9ClO2
Formula Weight:136.58
MOL File:543-27-1.mol

Isobutyl chloroformate Property

Melting point -80°C
Boiling point 128.8 °C(lit.)
Density 1.053 g/mL at 25 °C(lit.)
vapor pressure 0.33 mm Hg ( 20 °C)
refractive index n20/D 1.407(lit.)
Flash point 82 °F
storage temp. 2-8°C
solubility benzene: miscible
form Liquid
color Clear
Water Solubility Immiscible with water.
Sensitive Moisture Sensitive
Merck 14,5139
BRN 956590
Dielectric constant 9.2（20℃）
Stability Moisture Sensitive
CAS DataBase Reference 543-27-1(CAS DataBase Reference)
FDA UNII 6S785TC0OB
NIST Chemistry Reference Isobutyl chloroformate(543-27-1)
EPA Substance Registry System Isobutyl chloroformate (543-27-1)
UNSPSC Code 12352108
NACRES NA.22

Safety

Hazard Codes :T
Risk Statements :10-22-23-34
Safety Statements :26-36/37/39-45
RIDADR :UN 3390 6.1/PG 1
WGK Germany :2
F :10-19
TSCA :Yes
HazardClass :6.1
PackingGroup :I
HS Code :29159000
Toxicity :LD50 orally in Rabbit: 1400 mg/kg

NFPA 704:

	2
4		1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H226-H302-H314-H331
Precautionary statements P210-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338

Isobutyl chloroformate Price More Price(10)

Brand: Sigma-Aldrich(India)
Product number: 8.02358
Product name : Isobutyl chloroformate
Purity: for synthesis
Packaging: 100ML
Price: ₹3750
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 8.02358
Product name : Isobutyl chloroformate
Purity: for synthesis
Packaging: 250ML
Price: ₹6940
Updated: 2022/06/14
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Brand: ALFA India
Product number: ALF-A14692-36
Product name : Isobutyl chloroformate, 98%
Purity:
Packaging: 500g
Price: ₹8900
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-A14692-22
Product name : Isobutyl chloroformate, 98%
Purity:
Packaging: 100g
Price: ₹3534
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: C0178
Product name : Isobutyl Chloroformate
Purity:
Packaging: 25G
Price: ₹1900
Updated: 2022/05/26
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Isobutyl chloroformate Chemical Properties,Usage,Production

Chemical Properties clear liquid
Chemical Properties A combustible, colorless to light-colored liquid.
Uses Isobutyl chloroformate is used as a peptide reagent. It is also used in the preparation of phenethyl-carbamic acid isobutyl ester by reaction with phenethylamine.
General Description A colorless to light-colored liquid. Insoluble in water and denser than water. Very corrosive to skin, eyes, and mucous membranes. Very toxic by ingestion, inhalation and skin absorption. Combustible.
Air & Water Reactions Highly flammable. Insoluble in water. Reacts with moisture in the air to produce highly corrosive and toxic fumes of hydrogen chloride gas. Decomposes exothermically in water.
Reactivity Profile Isobutyl chloroformate is incompatible with water, with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Hazard Flammable. Corrosive.
Health Hazard TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
reaction suitability reaction type: Coupling Reactions
Potential Exposure This is a high volume chemical with production exceeding 1 million pounds annually in the U.S . No specific use found
Shipping UN2742 Chloroformates, toxic, corrosive, flammable, n.o.s., Hazard class: 6.1; Labels: 6.1—Poison Inhalation Hazard, 8—Corrosive material; 3—Flammable liquid; Technical Name Required, Potential Inhalation Hazard (Special Provision 5). PG II. UN3390 Toxic by inhalation liquid, corrosive, n.o.s. with an LC50 # 1000 mL/m3 and saturated vapor concentration ≥ 10 LC50, Hazard Class: 6.1; Labels: 6.1—Poisonous materials, 8—Corrosive material, Technical Name Required, Inhalation Hazard Zone B
Purification Methods It can be dried over CaCl2 and fractionated at atmospheric pressure while keeping moisture out. Its purity can be checked by conversion to the phenyl urethane derivative with PhNCO [Saunders et al. J Am Chem Soc 73 3796 1951.] IR: 1780cm-1 [Thompson & Jameson Spectrochim Acta 13 236 1959, R.se JustusLiebigs Ann Chem 205 227 1880]. [Beilstein 3 IV 26.]
Incompatibilities Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols, ethers, amines. Forms explosive mixture with air above flash point (27C). Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). Decomposes exothermically in water. Reacts with moisture in air to produce highly corrosive and toxic fumes of hydrogen chloride gas
Waste Disposal Disposal of unused product must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate protective equipment. For proper handling and disposal, always comply with federal, state, and local regulations.