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mebikar

mebikar Structure
mebikar
  • CAS No.10095-06-4
  • Chemical Name:mebikar
  • CBNumber:CB71344551
  • Molecular Formula:C8H14N4O2
  • Formula Weight:198.22
  • MOL File:10095-06-4.mol
mebikar Property
  • Melting point 226 - 229?C
  • Boiling point 362.2±42.0 °C(Predicted)
  • Density 1.237±0.06 g/cm3(Predicted)
  • storage temp. Refrigerator, under inert atmosphere
  • solubility Chloroform (Slightly), Methanol (Slightly)
  • form Solid
  • pka -0.49±0.20(Predicted)
  • color White to Off-White
  • FDA UNII 55FE6NPG89
Safety
  • HazardClass  :IRRITANT
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P330-P501

mebikar Chemical Properties,Usage,Production

  • Uses Temgicoluril (Tetramethylglycoluril) is an orally active antianxiety and antidepressant. Temgicoluril acts on GABA receptors to enhance GABA neurotransmission[1][2].
  • Definition ChEBI: Mebicar is an imidazolidinone.
  • in vivo

    Temgicoluril (10 mg/kg; Oral gavage; 3 weeks) has a preventive effect on neurobehavioral and immunological disruptions caused by intermittent unpredictable stress in mice[2].

    Animal Model:Intermittent unpredictable stress (IUS) treated seven week-old Balb/cByJ mice[2]
    Dosage:10 mg/kg
    Administration:Oral gavage (i.g.); 3 weeks
    Result:Recovered rapidly from anxiety-like behavior induced by the multiplexed stress compared with untreated mice.
    Did not prevent the decrease of brain-derived neurotropic factor by IUS exposure.
    Prevented elevation of serum corticosterone and secretion of proinflammatory cytokines from splenocytes due to IUS exposure.
  • References [1] Val'dman AV, Zaikonnikova IV, Kozlovskaia MM, Zimakova IE. Izuchenie osobennoste? spektra psikhotropnogo de?stviia mebikara [Characteristics of the psychotropic spectrum of action of mebicar]. Biull Eksp Biol Med. 1980 May;89(5):568-70. Russian. PMID:6104993
    [2] Kim CY, et al. Preventive Effect of Mebicar and Ginsenoside Rg1 on Neurobehavioral and Immunological Disruptions Caused by Intermittent Unpredictable Stress in Mice. Neuroimmunomodulation. 2018;25(1):49-58. DOI:10.1159/000489634
mebikar Preparation Products And Raw materials
Raw materials
Preparation Products
mebikar Suppliers
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mebikar Spectrum
10095-06-4, mebikarRelated Search:
  • 抑制剂
  • 原料药
  • 四氢-1,3,4,6-四甲基咪唑并(4,5-D)咪唑-2,5(1H,3H)-二酮
  • 化合物MEBIKAR
  • 2,4,6,8-四甲基-2,4,6,8-四偶氮二环(3.3.0)辛烷-3,7-二酮
  • 2,4,6,8-四氮杂双环[3.3.0]辛烷-3,7-二酮,2,4,6,8-四甲基-
  • 1,3,4,6-四甲基四氢咪唑并[4,5-D]咪唑-2,5(1H,3H)-二酮
  • 10095-06-4
  • Imidazo[4,5-d]imidazole-2,5(1H,3H)-dione,tetrahydro-1,3,4,6-tetramet
  • inhibit,Inhibitor,γ-Aminobutyric acid Receptor,Mebicar,Temgicoluril,Gamma-aminobutyric acid Receptor,GABA Receptor
  • Mebican
  • Mebicarum/TETRAMETHYLTETRAAZABICYCLOOCTANDION
  • Tetramethylglycoluril
  • Temgicoluril
  • Imidazo[4,5-d]imidazole-2,5(1H,3H)-dione, tetrahydro-1,3,4,6-tetramethyl-
  • 2,4,6,8-Тetramethyl-2,4,6,8,tetraazabycyclo[3.3.0] octane- 3,7-dione, Mebicar
  • Tetrahydro-1,3,4,6-tetramethylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione
  • Imidazo[4,5-d]im
  • 2,4,6,8-Tetramethyl-2,4,6,8-tetraazobizykl(3,3,0)oktandion-3,7 [German]
  • 2,4,6,8-Tetramethyl-2,4,6,8-tetraazobicyclo(3.3.0)octane-3,7-dione
  • 2,4,6,8-Tetraazabicyclo[3.3.0]octane-3,7-dione, 2,4,6,8-tetramethyl-
  • 1,3,4,6-Tetramethyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione
  • 1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-quinone
  • 1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-dione
  • Mebicar
  • 4,5-(1,3-Dimethylureylene)-1,3-dimethylimidazolidine-2-one
  • 3a,4,6,6a-Tetrahydro-1,3,4,6-tetramethylimidazo[4,5-d]imidazole-2,5(1H,3H)-dione
  • 2,4,6,8-Tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]-3,7-oxandione
  • mebikar

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