ChemicalBook CAS DataBase List 10095-06-4

10095-06-4

Name	mebikar
CAS	10095-06-4
Molecular Formula	C8H14N4O2
MDL Number	MFCD00184215
Molecular Weight	198.22
MOL File	10095-06-4.mol

Synonyms

mebikar Mebicar Mebican Temgicoluril Imidazo[4,5-d]im Tetramethylglycoluril Mebicarum/TETRAMETHYLTETRAAZABICYCLOOCTANDION 4,5-(1,3-Dimethylureylene)-1,3-dimethylimidazolidine-2-one 2,4,6,8-Tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]-3,7-oxandione 1,3,4,6-Tetramethyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione 2,4,6,8-Tetramethyl-2,4,6,8-tetraazobicyclo(3.3.0)octane-3,7-dione 1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-dione 1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-quinone 2,4,6,8-Tetraazabicyclo[3.3.0]octane-3,7-dione, 2,4,6,8-tetramethyl- Tetrahydro-1,3,4,6-tetramethylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione 2,4,6,8-Tetramethyl-2,4,6,8-tetraazobizykl(3,3,0)oktandion-3,7 [German] Imidazo[4,5-d]imidazole-2,5(1H,3H)-dione, tetrahydro-1,3,4,6-tetramethyl- 2,4,6,8-Тetramethyl-2,4,6,8,tetraazabycyclo[3.3.0] octane- 3,7-dione, Mebicar 3a,4,6,6a-Tetrahydro-1,3,4,6-tetramethylimidazo[4,5-d]imidazole-2,5(1H,3H)-dione inhibit,Inhibitor,γ-Aminobutyric acid Receptor,Mebicar,Temgicoluril,Gamma-aminobutyric acid Receptor,GABA Receptor

Chemical Properties

Melting point	226 - 229?C
Boiling point	362.2±42.0 °C(Predicted)
density	1.237±0.06 g/cm3(Predicted)
storage temp.	Refrigerator, under inert atmosphere
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	-0.49±0.20(Predicted)
color	White to Off-White

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501
HazardClass	IRRITANT

Hazard Information

Spectrum Detail

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Animal Model:	Intermittent unpredictable stress (IUS) treated seven week-old Balb/cByJ mice^[2]
Dosage:	10 mg/kg
Administration:	Oral gavage (i.g.); 3 weeks
Result:	Recovered rapidly from anxiety-like behavior induced by the multiplexed stress compared with untreated mice. Did not prevent the decrease of brain-derived neurotropic factor by IUS exposure. Prevented elevation of serum corticosterone and secretion of proinflammatory cytokines from splenocytes due to IUS exposure.

10095-06-4

Chemical Properties

Safety Data

Hazard Information

Uses

Definition

in vivo

References

Spectrum Detail

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