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VESNARINONE

VESNARINONE Structure
VESNARINONE
  • CAS No.81840-15-5
  • Chemical Name:VESNARINONE
  • CBNumber:CB6750484
  • Molecular Formula:C22H25N3O4
  • Formula Weight:395.45
  • MOL File:81840-15-5.mol
VESNARINONE Property
  • Melting point 238.1-239.5° (Tominaga); mp 238.1-239.8° (Shimizu)
  • Boiling point 519.41°C (rough estimate)
  • Density 1.2414 (rough estimate)
  • refractive index 1.6500 (estimate)
  • storage temp. Store at -20°C
  • solubility DMSO:9.84(Max Conc. mg/mL);24.88(Max Conc. mM)
    DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.26(Max Conc. mM)
    DMF:3.0(Max Conc. mg/mL);7.59(Max Conc. mM)
  • form A crystalline solid
  • pka 2.86(at 25℃)
  • color White to off-white
  • FDA UNII 5COW40EV8M
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

VESNARINONE Chemical Properties,Usage,Production

  • Description Vesnarinone is a new orally-active positive inotropic agent introduced for the treatment of congestive heart failure. It exerts a positive inotropic effect on the heart and has a peripheral vasodilatory effect. Vesnarinone is claimed not to affect heart rate or aggravate arrhythmia.
  • Description Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50s = 10.7 and 13.2 μM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC50 = 1.1 μM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dog, cat, rabbit, and guinea pig in a dose-dependent manner. Oral and i.v. administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.
  • Originator Otsuka (Japan)
  • Uses Cardiotonic.
  • Definition ChEBI: Arkin (TN) is an organic molecular entity.
  • brand name Arkin (Otsuka America);Arkin-Z.
VESNARINONE Preparation Products And Raw materials
Raw materials
Preparation Products
VESNARINONE Suppliers
Global(81)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
VESNARINONE Spectrum
81840-15-5, VESNARINONERelated Search:
  • 抑制剂
  • 杂化
  • 药物
  • 心脑血管药物
  • 强心药
  • 维司力农,10 MM DMSO 溶液
  • 6-(4-(3,4-二甲氧基苯甲酰基)哌嗪-1-基)-3,4-二氢喹啉-2(1H)-酮
  • 威那利酮
  • 3,4-二氢-6-[4-(3,4-二甲氧苯甲酰)-1-哌嗪基]-2(1H)-喹啉酮
  • 维司力农
  • 81840-15-5
  • Vesnarinone, 10 mM in DMSO
  • 6-(4-(3,4-Dimethoxybenzoyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one
  • OPC8212,phosphodiesterase 3,Inhibitor,OSC5,OPC 8212,oral activity,OSC4,OSC3,positive inotropic activity,Vesnarinone,heart failure,inhibit,Phosphodiesterase (PDE)
  • 2(1H)-Quinolinone, 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-
  • VESNARINONE USP/EP/BP
  • 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
  • CS-2139
  • OPC8212;OPC 8212;OPC-8212
  • Vesnarinone(OPC8212)
  • 0PC-8212
  • 6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone
  • OPC 8212
  • Piteranometozine
  • Arkin
  • VESNARINONE
  • 3，4-Dihydro-6-[4-(3，4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone

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