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Olprinone

Olprinone Structure
Olprinone
  • CAS No.106730-54-5
  • Chemical Name:Olprinone
  • CBNumber:CB2438515
  • Molecular Formula:C14H10N4O
  • Formula Weight:250.26
  • MOL File:106730-54-5.mol
Olprinone Property
  • Melting point >300°
  • Density 1.34±0.1 g/cm3(Predicted)
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • solubility DMSO
  • form Powder
  • pka 6.59±0.10(Predicted)
  • color White to off-white
  • CAS DataBase Reference 106730-54-5(CAS DataBase Reference)
  • FDA UNII 4Y8BMI9YGC
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

Olprinone Chemical Properties,Usage,Production

  • Description Oprinone is an injection developed by Japan Co., Ltd. for the treatment of acute heart failure. It is a specific PDEⅢ inhibitor that selectively blocks cAMP and has high selectivity for the inhibition of human cardiac PDEⅢ.
  • Uses Olprinone is used in the treatment of acute myocardial insufficiency.
  • Definition ChEBI: Olprinone is a member of bipyridines.
  • Side effects 1. In the treatment of heart failure, the main adverse reactions of opprinone are manifested in the circulatory system, including premature ventricular contraction, tachycardia, increased ventricular tachyarrhythmia, and increased heart rate. Electric monitoring;
    2. As a vasodilator, patients with renal insufficiency should use it in low doses. Long-term oral administration may lead to increased long-term mortality due to large adverse reactions, so it is only used for a short period of time.
  • Synthesis 4-(Dimethylamino)-3-(pyrimido[1,2-α]pyridin-6-yl)-3-buten-2-one and cyanoacetamide in dimethylformamide at 80~ Heating at 90°C for 12h to obtain Operinone.
Olprinone Preparation Products And Raw materials
Raw materials
Preparation Products
Olprinone Suppliers
Global(136)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
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  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
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  • Country：China
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  • Supplier：
    Chongqing Chemdad Co., Ltd
  • Tel：+86-023-6139-8061<br/>+86-86-13650506873
  • Email：sales@chemdad.com
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  • Supplier：
    SIMAGCHEM CORP
  • Tel： +86-13806087780
  • Email：sale@simagchem.com
  • Country：China
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Olprinone Spectrum
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  • 106730-54-5
  • Olprinone, 10 mM in DMSO
  • 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
  • Olprinone USP/EP/BP
  • 3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-
  • 3-phenylmethoxy-1-cyclobutanecarboxylic acid ethyl ester
  • 1，2-Dihydro-5-imidazo[1，2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile
  • Olprinone(Loprinone)
  • LOPRINONE
  • 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile
  • Olprinone [inn]
  • 5-(Imidazo[1,2-a]pyridine-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
  • OLPRINONE
  • 5-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-3-yl)-6-methyl-2-oxo-1h-pyridine-3-carbonitrile
  • 1,2-dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile

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