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METHDILAZINE (200 MG)

CAS No.1982-37-2
Chemical Name:METHDILAZINE (200 MG)
CBNumber:CB6501372
Molecular Formula:C18H20N2S
Formula Weight:296.43
MOL File:1982-37-2.mol

METHDILAZINE (200 MG) Property

Melting point 87-88℃
Boiling point 170 °C(Press: 0.04 Torr)
Density 1.185
refractive index 1.6000 (estimate)
pka pKa 7.45 (Uncertain)
FDA UNII 4Q13LY9Z8X
ATC code R06AD04
EPA Substance Registry System Methdilazine (1982-37-2)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

METHDILAZINE (200 MG) Chemical Properties,Usage,Production

Originator Tacaryl ,Westwood,US,1960
Uses Antipruritic.
Definition ChEBI: Methdilazine is a phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties. It has a role as a histamine antagonist, a cholinergic antagonist and an antipruritic drug. It is a member of phenothiazines and a N-alkylpyrrolidine.
Manufacturing Process 10.8 parts of 10-(1-methyl-3-pyrrolidylmethyl) phenothiazine (prepared from 1-methyl-3-pyrrolidylmethyl chloride by reaction with phenothiazine) in 80 parts of 99% isopropyl alcohol were treated with a solution of 1.33 parts of hydrogen chloride in 30 parts of the same solvent. The clear light yellow solution soon deposited white crystals of the acid addition salt. After cooling overnight at 0°C, the crystalline product was collected on a filter, washed with 99% isopropyl alcohol and anhydrous ether and then dried in a vacuum oven at 95°C. Yield 10.4 parts, MP 187.5° to 189°C.
brand name Tacaryl (Westwood-Squibb).
Therapeutic Function Antipruritic
General Description Methdilazine, 10-[(1-methyl-3-pyrrolidinyl)methyl]phenothiazine (Tacaryl), is a light-tan crystallinepowder that has a characteristic odor and is practicallyinsoluble in water. Methdilazine, as the free base, isused in chewable tablets because its low solubility in watercontributes to its tastelessness. Some local anesthesia of thebuccal mucosa may be experienced if the tablet is chewedand not swallowed promptly.
General Description Crystals.
Reactivity Profile METHDILAZINE (200 MG) is sensitive to light. .
Health Hazard SYMPTOMS: Symptoms of exposure to METHDILAZINE (200 MG) may include drowsiness, hypotension, tachycardia, dryness of the mouth, nausea, nasal congestion, fever and tremors.
Fire Hazard Flash point data for METHDILAZINE (200 MG) are not available. METHDILAZINE (200 MG) is probably combustible.