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Trimeprazine

Trimeprazine Structure
Trimeprazine
  • CAS No.84-96-8
  • Chemical Name:Trimeprazine
  • CBNumber:CB0146078
  • Molecular Formula:C18H22N2S
  • Formula Weight:298.45
  • MOL File:84-96-8.mol
Trimeprazine Property
  • Melting point 68°C
  • Boiling point bp0.3 150-175°
  • Density 1.1163 (rough estimate)
  • refractive index 1.6000 (estimate)
  • pka pKa 9.00 (Uncertain)
  • Water Solubility 0.942 mg/L
  • CAS DataBase Reference 84-96-8
  • FDA UNII 76H78MJJ52
  • NIST Chemistry Reference Trimeprazine(84-96-8)
  • ATC code R06AD01
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H318-H301-H411-H317
  • Precautionary statements P264-P270-P301+P310-P321-P330-P405-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P280-P305+P351+P338-P310

Trimeprazine Chemical Properties,Usage,Production

  • Originator Temaril,SKF,US,1958
  • Uses antipruritic
  • Uses Trimeprazine is used for treating itching during dermatitis of both allergic and nonallergic origin.
  • Definition ChEBI: Trimeprazine is a member of phenothiazines.
  • Manufacturing Process 95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6 grams) in xylene (140 cc) at a temperature of 130°C and the mixture is heated with reflux for 2 hours.
    A 0.61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in xylene is then added over 50 minutes and heating with reflux is continued for 20 hours. After cooling, the mixture is treated with water (40 cc) and N methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated with aqueous sodium hydroxide (density = 1.33; 10 cc) and extracted with ether.
    The extract is dried over potassium carbonate and evaporated and the residue is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (12.6 grams) is collected, distilling between 150° and 175°C under a pressure of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal hydrogen chloride, a hydrochloride is obtained, MP 216° to 217°C.
  • brand name Temaril (Allergan).
  • Therapeutic Function Antipruritic
Trimeprazine Preparation Products And Raw materials
Raw materials
Preparation Products
Trimeprazine Suppliers
Global(65)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
Trimeprazine Spectrum
84-96-8, TrimeprazineRelated Search:
  • TEMARIL
  • 抑制剂
  • 其他化学试剂
  • C18H22N2S
  • 84-86-8
  • 化合物 ALIMEMAZINE
  • 阿利美嗪草酸盐
  • 化合物 T10281
  • 异丁嗪
  • N,N,2-三甲基-3-吩噻嗪-10-基-1-丙胺
  • 阿利马嗪
  • N,N,2-三甲基-3-(10H-苯氧噻嗪-10-基)丙-1-胺
  • 84-96-8
  • Trimeprazine USP/EP/BP
  • 10H-Phenothiazine-10-propanaMine,N,N,b-triMethyl-
  • N,N,2-triMethyl-3-(10H-phenothiazin-10-yl)propan-1-aMine
  • dimethyl-(2-methyl-3-phenothiazin-10-yl-propyl)amine
  • TRIMEPRAZINE
  • Alimemazine-d6 MALEATE SALT
  • Trimeperazine
  • Teralen
  • Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-
  • N,N,2-Trimethyl-3-(10H-phenothiazin-10-yl)-1-propanamine
  • Methylpromazine
  • Bayer 1219
  • Alimezine
  • 10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-
  • 10-[3-(Dimethylamino)-2-methylpropyl]phenothiazine
  • 10-[2-Methyl-3-(dimethylamino)propyl]phenothiazine
  • alimemazine
  • Trimeprazine (base and/or unspecified salts)
  • ALIMENAZINE
  • Teralene
  • Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]- (6CI, 8CI)
  • dl-Trimeprazine
  • 10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-
  • n,n,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine

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