ChemicalBook > CAS DataBase List > (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT

CAS No.60-99-1
Chemical Name:(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
CBNumber:CB5488571
Molecular Formula:C19H24N2OS
Formula Weight:328.47
MOL File:60-99-1.mol

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Property

Safety

Hazard and Precautionary Statements (GHS)

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Chemical Properties,Usage,Production

Originator Levoprome ,Lederle,US,1966
Uses (R)-Methotrimeprazine acts as an analgesic agent.
Definition ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.
Manufacturing Process 95% sodamide (2.33 g) is added to a boiling solution of 3- methoxyphenthiazine (12 g) in anhydrous xylene (150 cc) and the mixture is heated with agitation under reflux for 1? hours. A solution of 1- dimethylamino-2-methyl-3-chloropropane (8.2 g) in anhydrous xylene (90 cc) is then run in over a period of 45 minutes while the reaction temperature is maintained and heating under reflux is continued for 18 hours.
After cooling, the reaction mixture is agitated with a mixture of water (40 cc) and a normal solution of methanesulfonic acid (70 cc), the xylene layer is removed and the acid liquors are washed with ether (200 cc). The aqueous phase is then made alkaline with sodium hydroxide (d = 1.33; 10 cc) and the liberated base is extracted with ether. The ethereal solution is dried over anhydrous potassium carbonate and concentrated at normal pressure. On distillation of the residue under reduced pressure 3-(3-methoxy-10- phenthiazinyl)-2-methyl-1-dimethylaminopropane (11.3 g) is obtained, MP 103°C, BP 182° to 191°C/0.15 mm Hg. The hydrochloride prepared in isopropanol melts at about 90°C.
brand name Levoprome (Immunex).
Therapeutic Function Analgesic

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Preparation Products And Raw materials

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(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Spectrum

60-99-1, (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALTRelated Search:

Pharmaceuticals
Intermediates & Fine Chemicals
抑制剂
医药原料
C19H24N2OSC4H4O4
甲氧异丁嗪
化合物 LEVOMEPROMAZINE
马来酸甲氨蝶呤-D3
化合物 T15743
左美丙嗪 USP标准品
左美吗嗪
左美丙嗪
甲氧并丁嗪
60-99-1
Levomepromazine for system suitability
Methotrimeprazine (1415006)
(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT USP/EP/BP
methotrimeprazine maleate USP/EP/BP
(2R)-3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
RP 7044
Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-2-methoxy-, (-)-
Nozinane
Nozinan
nomizan
Nirvan
nirnamine
Neurocil
n,beta-trimethyl-2-methoxy-(r)-10h-phenothiazine-10-propanamin
minozinan
milezin
methoxytrimeprazine
methotrimeprazine
Mepromazine
Levotomin
Levopromethazine
Levoprome
levopromazioni
Levopromazine
Levomepropazine
Levomepromazine
Levomepromazin
Levomeprazine
hirnamine
Hirnamin
dedoran
cl53212
cl39743
cl36467
CL 39743
CL 36467
bayer1213
arc-vi-c-5
7044 R.P.
3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine
2-Methoxytrimeprazine
10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (R)-
10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (-)-
(-)-phenothiazin