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L-745,870 TRIHYDROCHLORIDE

L-745,870 TRIHYDROCHLORIDE Structure
L-745,870 TRIHYDROCHLORIDE
  • CAS No.158985-00-3
  • Chemical Name:L-745,870 TRIHYDROCHLORIDE
  • CBNumber:CB6481216
  • Molecular Formula:C18H19ClN4
  • Formula Weight:326.82
  • MOL File:158985-00-3.mol
L-745,870 TRIHYDROCHLORIDE Property
  • Boiling point 571.4±50.0 °C(Predicted)
  • Density 1.31±0.1 g/cm3(Predicted)
  • storage temp. Desiccate at +4°C
  • solubility DMSO:16.5(Max Conc. mg/mL);50.49(Max Conc. mM)
  • pka 8.20±0.20(Predicted)
  • form Solid
  • color White to off-white
  • Water Solubility water: soluble
  • FDA UNII J3OLN3XSX7
  • UNSPSC Code 12352200
  • NACRES NA.77
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

L-745,870 TRIHYDROCHLORIDE Chemical Properties,Usage,Production

  • Uses L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.
  • Definition ChEBI: 3-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine is a member of piperazines.
  • Biological Activity A highly potent and selective D 4 dopamine receptor antagonist; L-745,870 has K i values of 0.51, 2300 and 960 nM for D 4 , D 3 and D 2 subtypes respectively and > 1000-fold selectivity over 5-HT 2 , D 1 and D 5 receptors.
  • in vivo

    L-745870 has good pharmacokinetic properties (20-60% oral bioavailability and plasma t1/2 2.1-2.8 hours) in both rat and monkey, and excellent brain penetration with high brain to plasma ratios in rat[2].
    Following oral administration to squirrel monkeys, L745870 (10 mg/kg p.o.) induces mild sedation and extrapyramidal motor symptoms, notably bradykinesia, became apparent at 30 mg/kg. Lower doses of L-745870 has no observable behavioural effects in monkeys[2].

  • IC 50 Human D4 Receptor: 4.3 nM (Ki); D2 Receptor: 960 nM (Ki); D3 Receptor: 2300 nM (Ki)
L-745,870 TRIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
L-745,870 TRIHYDROCHLORIDE Suppliers
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L-745,870 TRIHYDROCHLORIDE Spectrum
158985-00-3, L-745,870 TRIHYDROCHLORIDERelated Search:
  • 抑制剂
  • C18H19N4Cl3HCl
  • C18H22Cl4N4
  • 3-[4-(4-氯苯基)-1-哌嗪基]甲基]-1H-吡咯,[2,3-B]吡啶
  • 化合物 L-745870
  • 化合物 T11799L
  • 3-((4-(4-氯苯基)哌嗪-1-基)甲基)-1H-吡咯并[2,3-B]吡啶
  • 三氢氯酸L-745,870
  • 3-[[4-(4-氯苯基)-1-哌嗪基]甲基]-1H-吡咯并[2,3-B]吡啶
  • (3-(4-(4-氯苯基)-3-)甲基)-1H-吡咯并[2,3-B]吡啶-三盐酸盐
  • 158985-00-3
  • L 745870,L745870
  • L-745,870 trihydroch
  • 1H-Pyrrolo[2,3-b]pyridine, 3-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-
  • 3-[[4-(4-Chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine
  • L 745870
  • 3-(4-[4-CHLOROPHENYL]PIPERAZIN-1-YL)-METHYL-1H-PYRROLO[2,3-B]PYRIDINE TRIHYDROCHLORIDE
  • 3HCl
  • L-745,870 TRIHYDROCHLORIDE

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