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PyBOP

PyBOP Structure
PyBOP
  • CAS No.128625-52-5
  • Chemical Name:PyBOP
  • CBNumber:CB6434717
  • Molecular Formula:C18H28F6N6OP2
  • Formula Weight:520.39
  • MOL File:128625-52-5.mol
PyBOP Property
  • Melting point 154-156 °C (dec.)(lit.)
  • Density 1.438 at 20℃
  • vapor pressure 0-0Pa at 20-50℃
  • storage temp. 2-8°C
  • solubility methanol: 25 mg/mL, clear
  • form Fine Crystalline Powder
  • color White to off-white
  • Sensitive Moisture Sensitive
  • BRN 3584612
  • InChI InChI=1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
  • InChIKey BYCLGHOAELJLOF-UHFFFAOYSA-M
  • SMILES [P+](ON1N=NC2C=CC=CC1=2)(N1CCCC1)(N1CCCC1)N1CCCC1.[P-](F)(F)(F)(F)(F)F
  • LogP -0.3 at 26℃ and pH3.5-3.7
  • CAS DataBase Reference 128625-52-5(CAS DataBase Reference)
  • UNSPSC Code 12352107
  • NACRES NA.22
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H317-H410
  • Precautionary statements P261-P264-P273-P280-P301+P312-P302+P352
PyBOP Price More Price(14)
  • Brand: Sigma-Aldrich(India)
  • Product number: 8.51009
  • Product name : PyBOP
  • Purity: Novabiochem?
  • Packaging: 25G
  • Price: ₹8090
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 8.51009
  • Product name : PyBOP
  • Purity: Novabiochem?
  • Packaging: 100G
  • Price: ₹24220
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 8.51009
  • Product name : PyBOP
  • Purity: Novabiochem?
  • Packaging: 8510091000
  • Price: ₹115920
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 377848
  • Product name : (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
  • Purity: 98%
  • Packaging: 1G
  • Price: ₹1591.28
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 377848
  • Product name : (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
  • Purity: 98%
  • Packaging: 5G
  • Price: ₹3886.18
  • Updated: 2022/06/14
  • Buy: Buy

PyBOP Chemical Properties,Usage,Production

  • Chemical Properties Off-White Solid
  • Uses One of the most convenient coupling reagents for peptide synthesis without carcinogenic by-products. It replaces BOP reagent. This is especially suitable for solid-phase peptide synthesis, avoids racemization.
  • Uses 1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate (PyBOP) is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.
  • Uses PyBOP is a reagent for: Synthesis of single labeled oligonucleotides that fluoresce upon matched hybridization
    Generation of endocrine disruptor chemical binders
    Cycloaddition to template-assembled multivalent peptide conjugates
  • Definition PyBOP (benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) coupling reagent was selected for the peptidic bond formation. This selection was because PyBOP is efficient and could generate less toxic byproducts. PyBOP is an efficient coupling reagent utilized in solid-phase peptide synthesis. It reacts similarly to BOP, but its byproduct is not highly carcinogenic. PyBOP was utilized in the solid-phase synthesis of the tetrapeptide H-Ile-Ala-Leu-Pro-OH on 2-chlorotrityl resin. In contrast to uronium-based coupling reagents, PyBOP does not form guanidinated byproducts when used in excess. This makes it useful in fragment condensation reactions and head-to-tail cyclizations[1].
  • General Description (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.
  • reaction suitability reaction type: Coupling Reactions
  • References [1] Maharani, R. et al. “Good coupling performance of PyBOP in the solid-phase synthesis of tetrapeptide, OH-Pro-Leu-Ala-Ileu-NH2.” 2017. 0.
PyBOP Preparation Products And Raw materials
Raw materials
Preparation Products
PyBOP Suppliers
Global(561)Suppliers
  • Supplier：
    Watson Biotechnology Co.,Ltd
  • Tel：+86-18186686046<br/>+86-18186686046
  • Email：sales01@watsonbiotech.cn
  • Country：China
  • ProdList：5849
  • Advantage：58
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
PyBOP Spectrum
128625-52-5, PyBOPRelated Search:
  • Aromatics
  • peptides
  • Miscellaneous Reagents
  • Peptide
  • Synthetic Organic Chemistry
  • Phosphonium Compounds
  • Peptide Synthesis
  • Coupling Reactions (Peptide Synthesis)
  • Condensation & Active Esterification
  • Biochemistry
  • Amino Acid Derivatives
  • Peptide coupling agents
  • Peptide Coupling Reagents
  • 其它原料及中间体
  • 高端化学
  • 化工原料及中间体
  • 原料药
  • 原料药关键起始物料
  • 生物化工-氨基酸及其衍生物
  • 化学试剂-精细化工
  • 试剂
  • 其他
  • 氨基酸
  • 其他原料
  • 原料
  • 医药 偶联剂
  • 化学试剂
  • 多肽
  • 保护氨基酸
  • 肽键缩合剂
  • 多肽偶联剂
  • 催化剂
  • 耦合
  • 医药中间体
  • 苯并杂环
  • 缩合试剂
  • 合成试剂
  • Condensation & Active Esterification
  • Coupling Reactions (Peptide Synthesis)
  • Peptide Synthesis
  • Phosphonium Compounds
  • Synthetic Reagents
  • Coupling
  • Analytical Chromatography Product Catalog
  • Analytical Reagents
  • Phosphonium/Uronium/Formamidinium
  • C18H28N6OPPF6
  • C18H28N6OP稦6P
  • C18H28N6OPF6P
  • C18H28F6N6OP2
  • 1286225-52-5
  • 1H-苯并三唑-1-基氧三吡咯 烷基六氟磷酸盐[用于肽的偶联剂](128625-52-5)
  • 1H-苯并三唑-1-基氧三吡咯烷基六氟磷酸盐(BYPOB)
  • 1H-苯并三唑-1-基氧三吡咯烷基鳞六氟磷酸盐
  • 1H-苯并三唑-1-基氧三吡咯烷基鏻六氟磷酸盐,98%
  • PYBOP 1H-苯并三唑-1-氧基三(1-吡咯烷基)膦六氟磷酸盐
  • BENZOTRIAZOLE-1-YL-OXYTRIPYRROLIDINOPHOSPHONIUMHEXAFLUOROPHOSPHATE1H-苯并三唑-1-基氧三吡咯烷基六氟磷酸盐
  • 1H-苯并三唑-1-基氧三吡咯烷基六氟磷酸盐[用于肽的偶联剂 多肽试剂 PYBOP

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