ChemicalBook > CAS DataBase List > Lycorine hydrochloride

Lycorine hydrochloride

Lycorine hydrochloride Structure
Lycorine hydrochloride
  • CAS No.2188-68-3
  • Chemical Name:Lycorine hydrochloride
  • CBNumber:CB6415905
  • Molecular Formula:C16H17NO4
  • Formula Weight:287.31
  • MOL File:2188-68-3.mol
Lycorine hydrochloride Property
  • Melting point 206 °C
  • storage temp. Keep in dark place,Inert atmosphere,2-8°C
  • solubility Soluble in water (15 mg/ml)
  • form powder
  • color White to off-white
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
  • FDA UNII 58F70VH0HS
  • UNSPSC Code 12352202
  • NACRES NA.77
Safety
  • Hazard Codes  :T
  • Risk Statements  :25
  • Safety Statements  :45
  • RIDADR  :UN 2811 6.1/PG 3
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301
  • Precautionary statements P264-P270-P301+P310-P405-P501
Lycorine hydrochloride Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: L5139
  • Product name : Lycorine hydrochloride
  • Purity: ≥98% (TLC), powder
  • Packaging: 20MG
  • Price: ₹29779.58
  • Updated: 2022/06/14
  • Buy: Buy

Lycorine hydrochloride Chemical Properties,Usage,Production

  • Description Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4?A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5
  • Uses Lycorine Hydrochloride is the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.
  • Biochem/physiol Actions A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.
  • in vivo

    Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry[1].

    Animal Model:6- to 8-week-old BALB/C nude mice[1]
    Dosage:0 μg, 7.5 μg, 15 μg
    Administration:Subcutaneous injection; for 14 days
    Result:Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
  • References Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; Nat. Prod., 68 168 Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483 Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407 Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174 Zheng et al. (2020), The Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1
Lycorine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Lycorine hydrochloride Suppliers
Global(289)Suppliers
  • Supplier：
    BINBO BIOLOGICAL CO.,LTD
  • Tel： +8618629063126
  • Email：info@binbobiological.com
  • Country：China
  • ProdList：452
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29858
  • Advantage：58
  • Supplier：
    Xi'an Kono chem co., Ltd.,
  • Tel：029-86107037<br/>13289246953
  • Email：info@konochemical.com
  • Country：China
  • ProdList：1169
  • Advantage：58
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
Lycorine hydrochloride Spectrum
2188-68-3, Lycorine hydrochlorideRelated Search:
  • RNA-Protein Translation Inhibitors
  • P to
  • Gene Regulation and Expression
  • Enzyme Inhibitors by Enzyme
  • Peptidyl transferaseCell Signaling and Neuroscience
  • standardized herbal extract
  • reference standards from Chinese medicinal herbs (TCM).
  • phytochemical
  • pharmaceutical intermediate
  • chemical reagent
  • Inhibitors
  • 生物碱类
  • 抑制剂
  • 试剂
  • 高端化学
  • 药靶配体
  • 原料药
  • 抗寄生虫
  • 其他原料
  • 标准品-对照品
  • 标准品 -中药标准品
  • 分析试剂-标准品
  • 标准品-中药标准品
  • 植物成分单体
  • 细胞生物学试剂
  • 分析试剂标准品
  • 植物药
  • 小分子抑制剂，天然产物
  • 对照品
  • 中间体
  • 小分子抑制剂
  • 植物提取物
  • 分析标准品
  • 标准品
  • 中药对照品
  • 植物生化提取物
  • 植提标准品
  • 中药标准品
  • 植提
  • RNA-Protein Translation Inhibitors
  • Gene Regulation and Expression
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • C16H17NO4HCl
  • 优选]LYCORINE HYDROCHLORIDE
  • 优选]LYCORINE CHLORIDE
  • 盐酸石蒜碱对照品
  • 标准品对照品】LYCORINE CHLORIDE
  • (1S,2S,3A1S,12BS)-2,3A1,4,5,7,12B-六氢-1H-[1,3]二氧杂环戊烯并[4,5-J]吡咯并[3,2,1-DE]菲啶-1,2-二醇盐酸盐
  • 异鼠李素-3-B-D-芸香糖甙(水仙甙)
  • VE-CADHERIN抑制剂(LYCORINE HYDROCHLORIDE)
  • 石蒜碱盐酸盐对照品,
  • 盐酸石蒜碱, 96%(HPLC)
  • 盐酸石蒜碱(石蒜碱盐酸盐
  • LYCORINE CHLORIDE 盐酸石蒜碱 标准品
  • 盐酸石蒜碱(标准品)
  • 异鼠李素-3-Β-D-芸香糖甙

Home

My