2188-68-3

Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4?A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Lycoris radiata bulbs.

Lycorine Hydrochloride is the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.

A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.

Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; Nat. Prod., 68 168 Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483 Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407 Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174 Zheng et al. (2020), The Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1