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BENZETIMIDE

BENZETIMIDE Structure
BENZETIMIDE
  • CAS No.21888-98-2
  • Chemical Name:BENZETIMIDE
  • CBNumber:CB6343451
  • Molecular Formula:C23H26N2O2
  • Formula Weight:362.46
  • MOL File:21888-98-2.mol
BENZETIMIDE Property
  • Melting point 181-183°
  • alpha D20 +125° (chloroform)
  • Boiling point 543.9±50.0 °C(Predicted)
  • Density 1.178±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO: ≥ 100 mg/mL (275.89 mM)
  • pka 11.20±0.40(Predicted)
  • form Solid
  • color White to off-white
  • FDA UNII 43477QYX3D
Safety
  • RIDADR  :3249
  • HazardClass  :6.1(b)
  • PackingGroup  :III
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

BENZETIMIDE Chemical Properties,Usage,Production

  • Originator Tremblex,Brocades,Italy,1981
  • Uses Anticholinergic.
  • Definition ChEBI: Dexetimide is a member of piperidines.
  • Manufacturing Process 400 parts glacial acetic acid are cooled to 10°C to 20°C. Then there are added first dropwise 300 parts concentrated sulfuric acid followed by portionwise addition of 50 parts dl-1-benzyl-4-(1,3-dicyano-1-phenylpropyl)-piperidine hydrochloride at the same temperature. After the addition is complete, the whole is heated to 125°C in the course of 15 to 20 minutes. This temperature is then maintained for 10 minutes. After cooling, the reaction mixture is poured into ice, alkalized with NH4OH at a temperature < 20°C and extracted with chloroform. The chloroform layer is first washed twice with a K2CO3 5% solution, and then washed twice with water, dried over MgSO4, filtered and evaporated. The residue is dissolved in a mixture of 320 parts acetone and 600 parts diisopropylether, filtered and HCl gas is introduced into the filtrate. The solid hydrochloride is filtered off and dried, to yield 43 parts less pure lbenzyl-4-(2.6-dioxo-3-phenyl-3-piperidyl)-piperidine hydrochloride, melting point 283°C to 294°C.
    A sample of 4 parts is recrystallized from a boiling mixture of 80 parts isopropanol, 40 parts methanol and 500 parts water. The whole is filtered and after cooling the filtrate overnight at -20°C, 1-benzyl-4-(2,6-dioxo-3phenyl-3- piperidyl)-piperidine hydrochloride is obtained, melting point 299°C to 301.5°C, as a white amorphous powder.
    The dextro-isomer may be separated via the dextro-camphorsulfonate of the base.
  • Therapeutic Function Anticholinergic (ophthalmic)
BENZETIMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
BENZETIMIDE Suppliers
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BENZETIMIDE Spectrum
21888-98-2, BENZETIMIDERelated Search:
  • 抑制剂
  • 21888-96-9
  • 化合物 DEXETIMIDE
  • RSYY右苄替米特
  • 化合物 T15104
  • S-(+)-右苄替米特
  • 苄替米特
  • S(+)-右苄替米特 盐酸盐
  • S(+)-3-苯基-1′-(苯基甲基)-[3,4′-双哌啶]-2,6-二酮
  • R 16470 盐酸盐
  • 右苄替米特
  • 21888-98-2
  • RSYYBENZETIMIDE
  • (+)-Benzetimide
  • BENZETIMIDE USP/EP/BP
  • [3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (3S)-
  • (S)-(+)-Dexetimide
  • (3S)-3-(1-Benzyl-4-piperidyl)-3-phenylpiperidine-2,6-dione
  • S(+)-DEXETIMIDE HYDROCHLORIDE (R16470) H IGH AFFINITY MUSCARI
  • S(+)-DEXETIMIDE HYDROCHLORIDE
  • (S)-(+)-3-PHENYL-1'-(PHENYLMETHYL)-[3,4'-BIPIPERIDINE]-2,6-DIONE, HCL
  • R 16470
  • 3-PHENYL-1'-(PHENYLMETHYL)-[3,4'-BIPIPERIDINE]-2,6-DIONE HYDROCHLORIDE
  • BENZETIMIDE
  • (+)-DEXETIMIDE HYDROCHLORIDE
  • DEXETIMIDE HCL
  • Dextrobenzetimide
  • Dexbenzetimide
  • [3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (S)-

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