NODULARIN

NODULARIN Property

Density 1.29±0.1 g/cm3(Predicted)
Flash point 11℃
storage temp. −20°C
solubility methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.
form Dry residue containing traces of monobasic potassium phosphate.
pka 3.39±0.70(Predicted)
FDA UNII 0979BIK2QU
IARC 3 (Vol. 94) 2010
EPA Substance Registry System Nodularin (118399-22-7)
UNSPSC Code 85151701
NACRES NA.24

Safety

Hazard Codes :T,F,T+
Risk Statements :23/24/25-38-39/23/24/25-11-43-36/37/38-26/27/28
Safety Statements :36/37-45-16-7-36/37/39-26
RIDADR :UN 2811 6.1/PG 2
WGK Germany :3
RTECS :GU2294250
Hazardous Substances Data :118399-22-7(Hazardous Substances Data)
Toxicity :mouse,LD50,intraperitoneal,60ug/kg (0.06mg/kg),Chemical Research in Toxicology. Vol. 6, Pg. 151, 1993.

NFPA 704:

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H300+H310+H330-H315-H317-H319-H335
Precautionary statements P260-P262-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338

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NODULARIN Chemical Properties,Usage,Production

Description The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC₅₀ values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC₅₀ of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.
Uses Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.
Definition Toxin produced by blue green algae.

NODULARIN Preparation Products And Raw materials

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NODULARIN Spectrum

118399-22-7, NODULARINRelated Search:

Natural Products
抑制剂
Enzymes, Inhibitors, and Substrates
Cyanobacterial Toxins
Cell Signaling Enzymes
BioChemical
Biochemicals and Reagents
Application Index
C41H60N8O10
节球毒素
节球毒素溶液
环[(2S,3S,4E,6E,8S,9S)-3-氨基-9-甲氧基-2,6,8-三甲基-10-苯基-4,6-癸二烯酰基-D-Γ-谷氨酰基-(2Z)-2-(甲氨基)-2-丁烯酰基-(3S)-3-甲基-DΒ-天冬氨酰-L-精氨酰)
118399-22-7
Nodularin in methanol
Cyclo[(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl]
IXBQSRWSVIBXNC-HSKGSTCASA-N
cyclo((z)-2,3-didehydro-n-methyl-2-aminobutanoyl-erythro-3-methyl-d-beta-aspar
Nodularin solution
Nodularin-R solution
Nodularin,1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
Cyclo(L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-beta-aspartyl)
Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl)
1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
Nodularin, Nodularia spumigena
1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE
NODULARIN
yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl)
tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth