Description Reference
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Pitavastatin

Description Reference
Pitavastatin Structure
Pitavastatin
  • CAS No.147511-69-1
  • Chemical Name:Pitavastatin
  • CBNumber:CB6206668
  • Molecular Formula:C25H24FNO4
  • Formula Weight:421.46
  • MOL File:147511-69-1.mol
Pitavastatin Property
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

Pitavastatin Chemical Properties,Usage,Production

  • Description Pitavastatin (Brand Name: LIVALO) is an inhibitor of HMG-CoA reductase which catalyzes the first step of cholesterol synthesis. It appears as odorless and white to pale-yellow powder. It takes effects by reducing the level of certain fatty substances such as cholesterol in the body. Therefore, it is mainly indicated for the treatment of hypercholesterolaemia and for the prevention of cardiovascular diseases. It can not only lower the high cholesterol and triglyceride in certain patients, but also can increase the content of high density lipoprotein (HDL), the “good” cholesterol levels. It should be generally administrated together with a proper diet.
  • Reference https://en.wikipedia.org/wiki/Pitavastatin
    http://www.rxlist.com/livalo-drug.htm
    https://www.drugs.com/cdi/pitavastatin.html
  • Uses HMGA reductase inhibitor
  • Definition ChEBI: A hydroxy monocarboxylic acid anion that is the conjugate base of pitavastatin, obtained by deprotonation of the carboxy group.
  • brand name [Name previously used: Itavastatin].
  • Biological Activity pitavastatin (nk-104) is a potent hmg-coa reductase inhibitor, pitavastatin inhibited cholesterol synthesis from acetic acid with an ic50 of 5.8 nm in a human liver cancer cell line (hepg2).
  • Enzyme inhibitor This HMG-CoA reductase inhibitor (FW = 421.46 g/mol; CAS 147511-69- 1; IUPAC Name: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin- 3-yl]-3,5-dihydroxyhept-6-enoic acid), also known as itavastatin, itabavastin, nisvastatin, NK-104, NKS-104, and the trade name Livalo?, is indicated for ameliorating hypercholesterolemia and preventing cardiovascular disease. NK-104 potency is dose-dependent and is roughly equivalent to that of atorvastatin. It is well-tolerated in the treatment of patients with hypercholesterolemia. Pitavastatin uptake is carrier-mediated. Target(s): Reduces inflammatory cytokine production from human bronchial epithelial cells; Decreases microtubule tau protein levels via the inactivation of Rho/ROCK; Inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model; Suppresses therosclerosis induced by chronic inhibition of the synthesis of nitric oxide in moderately hypercholesterolemic rabbits; Decreases the expression of endothelial lipase both in vitro and in vivo; Inhibits NFkB pathway in brain; Inactivates NFkB and decreases IL-6 production through Rho kinase pathway in MCF-7 human breast cancer cells; Reduces C-reactive-protein-induced interleukin-8 production in human aortic endothelial cells; Inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation; Inhibits upregulation of intermediate conductance calcium-activated potassium channels and coronary arteriolar remodeling induced by long-term blockade of nitric oxide synthesis; Inhibits migration and proliferation of rat vascular smooth muscle cells.
Pitavastatin Preparation Products And Raw materials
Raw materials
Preparation Products
Pitavastatin Suppliers
Global(144)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29859
  • Advantage：58
  • Supplier：
    AFINE CHEMICALS LIMITED
  • Tel：+86-0571-85134551
  • Email：sales@afinechem.com
  • Country：China
  • ProdList：15349
  • Advantage：58
Pitavastatin Spectrum
147511-69-1, PitavastatinRelated Search:
  • API
  • LIVALO
  • 化学试剂
  • 抑制剂
  • 杂质对照品
  • 原料药
  • 有机原料
  • C25H24FNO4
  • C25H23FNO4
  • 匹伐他汀-[D4]/精确称量
  • 化合物 T7072
  • 匹伐他汀酸
  • 匹伐他汀
  • (3R,5S,6E)-7-(2-环丙基-4-(4-氟苯基)喹啉-3-基)-3,5-二羟基庚-6-烯酸
  • 147511-69-1
  • Pitavastatin (>90%)
  • Compound T7072
  • Pitavastatin API
  • PitavastatinQ: What is Pitavastatin Q: What is the CAS Number of Pitavastatin Q: What is the storage condition of Pitavastatin
  • Pitavastatin USP/EP/BP
  • PITAVASTATIN (NK-104)
  • (E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoate
  • Atorvastatin therapy
  • monocalciumbis{(3r,5s,6e)-7-[2-cyclopyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate}
  • ITAVASTATIN
  • pitavastatin(1-)
  • Pitavastatin Acid
  • 6-Heptenoic acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, (S-(R*,S*-(E)))-
  • 6-Heptenoic acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, (3R,5S,6E)-
  • ( )-(3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoic acid
  • PITAVASTATIN
  • (3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid
  • PITVASTATIN
  • PitavastatinCa

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