ChemicalBook > CAS DataBase List > ELOCALCITOL

ELOCALCITOL

ELOCALCITOL Structure
ELOCALCITOL
  • CAS No.199798-84-0
  • Chemical Name:ELOCALCITOL
  • CBNumber:CB61509111
  • Molecular Formula:C29H43FO2
  • Formula Weight:442.65
  • MOL File:199798-84-0.mol
ELOCALCITOL Property
  • Boiling point 568.3±50.0 °C(Predicted)
  • Density 1.05±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility Ethanol:20.0(Max Conc. mg/mL);45.18(Max Conc. mM)
  • form A crystalline solid
  • pka 14.04±0.40(Predicted)
  • color White to off-white
  • optical activity [α]/D +97 to +107°, c =c=1 in methanol
  • FDA UNII 2WDS5F2V6Q
  • UNSPSC Code 12352200
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

ELOCALCITOL Chemical Properties,Usage,Production

  • Description BXL-628 is an analog of vitamin D3 that has diverse biological activities. It increases death of androgen-stimulated human benign prostatic hyperplasia (BPH) cells via induction of apoptosis in a dose-dependent manner. In vivo, BXL-628 completely inhibits androgen-stimulated prostate overgrowth in a rat model of BPH. It reduces expression of IL-13 and IgE/mast cell-derived protease 1 (MMCP1) and decreases edema and leukocyte infiltration in the bladder wall in a mouse model of allergen-induced interstitial cystitis. BXL-628 also reduces the number of adherent endometrial stromal cells and decreases the total weight of endometrial lesions in a mouse model of endometriosis. Formulations containing BXL-628 are under clinical investigation for the treatment of BPH.
  • Uses Elocalcitol (BXL-628) is a selective, orally active vitamin D receptor (VDR) agonist. Elocalcitol shows anti-inflammatory activity. Elocalcitol inhibits growth of prostate cancer cells[1][2].
  • References [1] Mariani M, et al. The selective vitamin D receptor agonist, elocalcitol, reduces endometriosis development in a mouse model by inhibiting peritoneal inflammation. Hum Reprod. 2012 Jul;27(7):2010-9. DOI:10.1093/humrep/des150
    [2] Marchiani S, et al. The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells. J Cancer Res Clin Oncol. 2006 Jun;132(6):408-16. DOI:10.1007/s00432-006-0086-8
ELOCALCITOL Preparation Products And Raw materials
Raw materials
Preparation Products
ELOCALCITOL Suppliers
Global(45)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32190
  • Advantage：58
  • Supplier：
    CR Corporation Limited
  • Tel： +8613062833949
  • Email：fred.wen@crcorporation.cn
  • Country：China
  • ProdList：8647
  • Advantage：58
  • Supplier：
    Coresyn Pharmatech Co., Ltd.
  • Tel：+86-571-86626709<br/>+86-18157142896
  • Email：cbc@coresyn.com
  • Country：China
  • ProdList：9984
  • Advantage：58
  • Supplier：
    PT CHEM GROUP LIMITED
  • Tel：+86-85511178;<br/>+86-85511178;
  • Email：peter68@ptchemgroup.com
  • Country：China
  • ProdList：35425
  • Advantage：58
ELOCALCITOL Spectrum
199798-84-0, ELOCALCITOLRelated Search:
  • 抑制剂
  • C29H43FO2
  • 化合物 ELOCALCITOL
  • 化合物 T19869
  • 艾洛骨化醇
  • 199798-84-0
  • Ro 26-9228
  • Cyclohexanol, 3-[(2E)-2-[(3aS,7aS)-1-[(1S,3E)-5-ethyl-5-hydroxy-1-methyl-3-hepten-1-yl]-3,3a,5,6,7,7a-hexahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylene-, (1R,3Z,5S)-
  • Ellocalciferol
  • (1R,3E,5S)-3-[(2E)-2-[(3aS,7aS)-1-[(E,2S)-6-ethyl-6-hydroxyoct-4-en-2-yl]-7a-methyl-3a,5,6,7-tetrahydro-3H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylidenecyclohexan-1-ol
  • BXL 628
  • ELOCALCITOL

Home

My