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Paricalcitol

Paricalcitol Structure
Paricalcitol
  • CAS No.131918-61-1
  • Chemical Name:Paricalcitol
  • CBNumber:CB0500520
  • Molecular Formula:C27H44O3
  • Formula Weight:416.65
  • MOL File:131918-61-1.mol
Paricalcitol Property
  • Boiling point 564.8±50.0 °C(Predicted)
  • Density 1.121±0.06 g/cm3(Predicted)
  • Flash point 14℃
  • storage temp. Store at -20°C,unstable in solution, ready to use.
  • solubility DMSO : 100 mg/mL (240.02 mM; Need ultrasonic)Ethanol : 12.5 mg/mL (30.00 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
  • pka 14.34±0.40(Predicted)
  • form Solid
  • color White to off-white
  • InChIKey BPKAHTKRCLCHEA-UBFJEZKGSA-N
  • SMILES C[C@]12CCC/C(=C\C=C3C[C@@H](O)C[C@H](O)C3)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C |&1:1,10,13,16,20,22,26,r|
  • CAS DataBase Reference 131918-61-1(CAS DataBase Reference)
  • FDA UNII 6702D36OG5
  • NCI Dictionary of Cancer Terms paricalcitol
  • NCI Drug Dictionary paricalcitol
  • ATC code H05BX02
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301+H311-H330-H372
  • Precautionary statements P280-P301+P310+P330-P302+P352+P312-P304+P340+P310-P314

Paricalcitol Chemical Properties,Usage,Production

  • Description Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.
  • Description Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
  • Chemical Properties White Solid
  • Originator Abbott (US)
  • Uses Antihyperparathyriod
  • Uses 1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
  • Uses Synthetic analog of vitamin D. Antihyperparathyroid.
  • Definition ChEBI: Paricalcitol is a seco-cholestane and a hydroxy seco-steroid. It has a role as an antiparathyroid drug. It is functionally related to a vitamin D2.
  • brand name Zemplar (Abbott).
  • Clinical Use Vitamin D analogue:
    Treatment and prevention of secondary hyperparathyroidism associated with chronic renal failure
  • Metabolism Extensively metabolised via hepatic and non-hepatic pathways to form two relatively inactive metabolites. After oral administration of 3 H-paricalcitol, only about 2% of the dose was eliminated unchanged in the faeces, and no parent drug found in the urine.
    Approximately 70% of the radioactivity was eliminated in the faeces and 18% was recovered in the urine. Most of the systemic exposure was from the parent drug.
Paricalcitol Preparation Products And Raw materials
Raw materials
Preparation Products
Paricalcitol Suppliers
Global(273)Suppliers
  • Supplier：
    airuikechemical co., ltd.
  • Tel：+86-18353166132<br/>+86-18353166132
  • Email：sales02@airuikechemical.com
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  • Tel：+86-（0）57185586718<br/>+86-13336195806
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    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
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    Biochempartner
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  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
Paricalcitol Spectrum
131918-61-1, ParicalcitolRelated Search:
  • 131918-61-1
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  • 131919-61-1
  • (1R,3R)-5-(2-((1R,3AS,7AR,E)-1-((2R,5S,E)-6-羟基-5,6-二甲基庚-3-烯-2-基)-7-甲基八氢-4H-茚-4-亚基)亚乙基)环己烷-1,3-二醇
  • 优选]PARICALCITOL
  • (1R,3R)-5-((E)-2-((1R,3AS,7AR)-1-((2R,5S,E)-6-羟基-5,6-二甲基庚-3-烯-2-基)-7A-甲基六氢-1H-茚-4(2H)-亚基)亚乙基)环己烷-1,3-二醇
  • 干冰运输][2H6]-帕立骨化醇
  • 帕立骨化醇/PARICALCITOL
  • 2,5-双羟基维他命D2
  • 帕立骨化醇 USP标准品
  • 帕里醇
  • 帕立骨化醇 5MG
  • 1,25-双羟基维他命D2
  • 帕立骨化醇
  • 帕立骨化醇(冷藏运输)
  • 131918-61-1
  • (1R,3R)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R,3E,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}cyclohexane-1,3-diol
  • Zemplarr
  • Paricalciferol
  • (1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)cyclohexane-1,3-diol
  • Zemplar
  • CS-1390
  • Paricalcitol (COLD SHIPMENT REQUIRED) (1499403)
  • ParicalcitolQ: What is Paricalcitol Q: What is the CAS Number of Paricalcitol Q: What is the storage condition of Paricalcitol Q: What are the applications of Paricalcitol
  • (1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-6-hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)cyclohexane-1,3-diol
  • 19-Nor-1,25- dihydroxyvitaMin D2
  • (1α,3β,7E,22E)-19-Nor-9,10-secoergosta-5,7,22-triene-1,3,25-triol
  • (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-Octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-triMethyl-2-hexen-1-yl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
  • Paricalcitol (10 mg) (COLD SHIPMENT REQUIRED)
  • Paricalcitol(Zemplar)
  • 1,25-DihydroxyvitaMin D2 Paricalcitol
  • Paricalcitol, >=98%
  • 1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3R,5Z)-
  • (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol
  • 19-nor-1alpha,25-dihydroxyvitamin D2
  • PARICALCITOL
  • PARICALCITOL (10 MG)F0E3030.997MG/MG(AI)
  • Paricalcitol/ 19-nor-1α,25-dihydroxyergocalciferol
  • 1α,25-Dihydroxy-19-nor-vitaMin D2

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