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Trimethylamine N-oxide

CAS No.1184-78-7
Chemical Name:Trimethylamine N-oxide
CBNumber:CB6140124
Molecular Formula:C3H9NO
Formula Weight:75.11
MOL File:1184-78-7.mol

Trimethylamine N-oxide Property

Melting point 220-222 °C (lit.)
Boiling point 133.8°C (rough estimate)
Density 0.9301 (rough estimate)
vapor pressure 23.5Pa at 20℃
refractive index 1.4698 (estimate)
FEMA 4245 | TRIMETHYLAMINE OXIDE
storage temp. Hygroscopic, Room Temperature, under inert atmosphere
solubility Chloroform, DMSO, Methanol (Slightly)
pka 4.65(at 25℃)
form Solid
color Pale Yellow
Odor odorless
Water Solubility 793g/L at 24.5℃
Merck 14,9711
JECFA Number 1614
Stability Hygroscopic
LogP -2.79
Substances Added to Food (formerly EAFUS) TRIMETHYLAMINE OXIDE
EWG's Food Scores 1
FDA UNII FLD0K1SJ1A
EPA Substance Registry System Methanamine, N,N-dimethyl-, N-oxide (1184-78-7)
UNSPSC Code 12352116
NACRES NA.22

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-37/39
WGK Germany :3
HS Code :2904.20.5000

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302+H332
Precautionary statements P261-P264-P270-P271-P301+P312-P304+P340+P312

Trimethylamine N-oxide Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: 317594
Product name : Trimethylamine N-oxide
Purity: 95%
Packaging: 1G
Price: ₹5813.03
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 317594
Product name : Trimethylamine N-oxide
Purity: 95%
Packaging: 5G
Price: ₹16421.53
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: T1362
Product name : Trimethylamine N-Oxide Anhydrous
Purity:
Packaging: 1G
Price: ₹3300
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: T1362
Product name : Trimethylamine N-Oxide Anhydrous
Purity:
Packaging: 5G
Price: ₹10800
Updated: 2022/05/26
Buy: Buy

Trimethylamine N-oxide Chemical Properties,Usage,Production

Description Trimethylamine N-oxide (TMAO) is a metabolite of choline, phosphatidylcholine, and L-carnitine . It is formed by gut microbiota-mediated metabolism of choline, phosphatidylcholine, and L-carnitine to TMA followed by oxidation of TMA by flavin-containing monooxygenase 3 (FMO3) in the liver. Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-prone ApoE^-/- mice. Plasma levels of TMAO are elevated in patients with chronic kidney disease and decreased in patients with active, compared with inactive, ulcerative colitis. Elevated plasma levels of TMAO are associated with increased risk of cardiovascular disease.
Chemical Properties Colorless to yellow solid; odorless.
Chemical Properties White crystalline powder
Uses Trimethylamine?N-oxide can be used:
- As a demetallation?and decarbonylation?reagent for organometallic compounds.
- To prepare azomethine ylide by reaction with lithium di-isopropylamide. This, in turn, may be reacted with simple alkenes to obtain corresponding pyrrolidines.
- To mediate the conversion of thiols to disulfides.
Definition ChEBI: An N-oxide derived from triethylamine.
General Description Trimethylamine?N-oxide is an organic compound that belongs to the class of amine oxides. It is generally found in the tissues of marine organisms, wherein it helps protect them from harsh conditions like salinity, hydrostatic pressure, temperature, and high urea.
Flammability and Explosibility Not classified
reaction suitability reagent type: oxidant