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CLOZAPINE N-OXIDE

CLOZAPINE N-OXIDE Structure
CLOZAPINE N-OXIDE
  • CAS No.34233-69-7
  • Chemical Name:CLOZAPINE N-OXIDE
  • CBNumber:CB4759216
  • Molecular Formula:C18H19ClN4O
  • Formula Weight:342.82
  • MOL File:34233-69-7.mol
CLOZAPINE N-OXIDE Property
  • Melting point 190-248°C
  • Flash point 9℃
  • storage temp. -20°C Freezer, Under Inert Atmosphere
  • solubility Soluble in DMSO.
  • form powder
  • pka 6.86±0.20(Predicted)
  • color Yellow
  • biological source synthetic
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
  • InChIKey OGUCZBIQSYYWEF-UHFFFAOYSA-N
  • FDA UNII MZA8BK588J
  • UNSPSC Code 12352119
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301-H336
  • Precautionary statements P301+P310+P330
CLOZAPINE N-OXIDE Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML2304
  • Product name : Clozapine N-oxide hydrochloride
  • Purity: ≥98% (HPLC), Water soluble Clozapine N-oxide
  • Packaging: 5MG
  • Price: ₹21134.4
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C0832
  • Product name : Clozapine N-oxide
  • Purity: 
  • Packaging: 5MG
  • Price: ₹21173.7
  • Updated: 2022/06/14
  • Buy: Buy

CLOZAPINE N-OXIDE Chemical Properties,Usage,Production

  • Description Clozapine-N-oxide (34233-69-7) is a clozapine?metabolite1?which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2?May be used to control grafted human pluripotent stem cell-derived neurons engineered to express DREADDs.3,4??Numerous other applications.5,6
  • Chemical Properties Yellow Solid
  • Uses Clozapine N-oxide has been used:
    • for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
    • for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
    • in behavioral testing in mice and for stimulating (HEK293) cells

  • Uses A 5-HT2 antagonist. A major metabolite of clozapine that can be monitored by HPLC. Possesses little or no activity towards serotonin receptors
  • Definition ChEBI: Clozapine N-oxide is a dibenzodiazepine.
  • General Description Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.
  • Biochem/physiol Actions 5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.
  • storage Room temperature (desiccate)
  • References 1) Eiermann?et al.?(1997),?The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine; Br. J. Clin. Pharmacol.,?44?439 2) Armbruster?et al.?(2007),?Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand; Proc. Natl. Acad. Sci. USA,?104?5163 3) Chen?et al.?(2016),?Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease; Cell Stem Cell,?18?817 4) Vazey and Aston-Jones (2014),?Designer receptors: therapeutic adjuncts to cell replacement therapy in Parkinson’s disease: J. Clin. Invest.,?124?2858 5) Gomez?et al.?(2017)?Chemogenetics revealed: DREADD occupancy and activation via converted clozapine; Science?357?503 6) Marcinkiewcz?et al. (2016)?Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala; Nature?537?97
CLOZAPINE N-OXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
CLOZAPINE N-OXIDE Suppliers
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CLOZAPINE N-OXIDE Spectrum
34233-69-7, CLOZAPINE N-OXIDERelated Search:
  • Metabolites
  • Various Metabolites and Impurities
  • 药靶配体
  • 原料药
  • 杂质对照品
  • 抑制剂
  • C18H19ClN4O2HCl
  • C18H19ClN4O
  • 氯氮平N-氧化物,10 MM DMSO 溶液
  • CLOZAPINE N-OXIDE,METABOLITE OF CLOZAPINE
  • CLOZAPINE N-OXIDE,METABOLITE OF CLOZAPINE (AQUEOUS SOLUTION)
  • CLOZAPINE N-OXIDE (氯氮平N-氧化物)
  • 4-(8-氯-5H-二苯并[B,E][1,4]二氮杂卓-1-基)-1-甲基哌嗪 1-氧化物
  • 4-(8-氯-5H-二苯并[B,E][1,4]重氮基庚英-11-基)-1-甲基哌嗪 1-氧化
  • 氯氮平N-氧化物(氯氮平杂质1)
  • 氯氮平一氧化氮
  • CLOZAPINE N-OXIDE (4-OXIDO-PIPRAZINYL)
  • 氯氮平N- OXIDE
  • 8-氯-4-甲基-5H-二苯并[B,E][1,4]二氮哌嗪
  • 氯氮平N-氧化
  • 氯氮平EP杂质8
  • 氯氮平氮氧化物
  • 氯氮平 N-氧化物
  • 氯氮平氮氧化合物
  • 34233-69-7
  • CLOZAPINE N-OXIDE, 10 mM in DMSO
  • Clozapine N-oxide, Metabolite of Clozapine
  • Clozapine N-oxide, Metabolite of Clozapine (aqueous solution)
  • Clozapine N-oxide (4-oxido-piprazinyl) in methanol
  • 4-(8-Chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide
  • Clozapine N-Oxide imp
  • 3-Chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine
  • Clozapine Impurity 16
  • Clozapine N-OxideQ: What is Clozapine N-Oxide Q: What is the CAS Number of Clozapine N-Oxide Q: What is the storage condition of Clozapine N-Oxide Q: What are the applications of Clozapine N-Oxide
  • 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-
  • Clozapine N-oxide (4-oxido-piprazinyl)
  • Clozapine N-Oxide (1.0 mg/mL in Methanol)
  • Clozapine N-oxide dihydrochloride NEW
  • Clozapine impurity 5/Clozapine N-Oxide/4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide
  • 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
  • Clozapine N-oxide (CNO)
  • Clozapine N-oxide solution
  • Clozapine N-oxide Methanol Adduct
  • MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS
  • 8-CHLORO-11-[4-METHYL-1-PIPERAZINYL]-5H-DIBENZO[B,E][1,4]DIAZEPINE N-OXIDE
  • CLOZAPINE N-OXIDE
  • e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(n-oxide

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