ChemicalBook > CAS DataBase List > (R)-Flecainide

(R)-Flecainide

(R)-Flecainide Structure
(R)-Flecainide
  • CAS No.99495-90-6
  • Chemical Name:(R)-Flecainide
  • CBNumber:CB61270172
  • Molecular Formula:C17H20F6N2O3
  • Formula Weight:414.34
  • MOL File:99495-90-6.mol
(R)-Flecainide Property
  • Boiling point 434.9±45.0 °C(Predicted)
  • Density 1.286±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility Ethanol: soluble; Methanol: soluble
  • form A solid
  • pka 14.15±0.46(Predicted)
  • color White to off-white
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

(R)-Flecainide Chemical Properties,Usage,Production

  • Description R-(–)-Flecainide is the (R) enantiomer of the antiarrhythmic agent flecainide . R-(–)-Flecainide prevents chloroform-induced ventricular fibrillation in mice (ED50 = 14.5 mg/kg). It also prevents ouabain-induced ectopic ventricular tachycardia in anesthetized dogs.
  • Uses R-Enantiomer of Flecainide. Antiarrhythmic (class IC).
  • in vivo

    R-(–)-Flecainide inhibits chloroform-induced fibrillation (9-20 mg/kg, po, single dose) in mice model with an ED50 of 14.5 mg/kg, and inhibits ouabain induced arrhythmias (1-3 mg/kg, ) in mongrel dog model, without toxicity[1].

    Animal Model:Chloroform-induced ventricular fibrillation in mice[1]
    Dosage:9-20 mg/kg
    Administration:po, single dose
    Result:Prevented fibrillation.
    Animal Model:Ouabain induced ventricular tachycardia in mongrel dog[1]
    Dosage:1-3 mg/kg
    Administration:iv, single dose
    Result:Inhibited arrhythmias.
(R)-Flecainide Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-Flecainide Suppliers
Global(21)Suppliers
  • Supplier： J & K SCIENTIFIC LTD.
  • Tel： 18210857532
  • Email：jkinfo@jkchemical.com
  • Country：China
  • ProdList：96815
  • Advantage：76
  • Supplier： BOC Sciences
  • Tel： 16314854226
  • Email：info@bocsci.com
  • Country：United States
  • ProdList：9923
  • Advantage：65
(R)-Flecainide Spectrum
99495-90-6, (R)-FlecainideRelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Chiral Reagents
  • R-(-)-氟卡胺
  • R -(-)-氟卡尼
  • 99495-90-6
  • N-[[(2R)-piperidin-2-yl]methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • N-[(R)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • N-[(2R)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • Benzamide, N-[(2R)-2-piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)-
  • Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, (R)-
  • (R)-Flecainide
  • (R)-(-)-Flecainide

Home

My