Indications and Usage Mechanisms of Action Adverse reactions Warnings and Precautions
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Fasudil hydrochloride

Indications and Usage Mechanisms of Action Adverse reactions Warnings and Precautions
Fasudil hydrochloride Structure
Fasudil hydrochloride
  • CAS No.105628-07-7
  • Chemical Name:Fasudil hydrochloride
  • CBNumber:CB6101699
  • Molecular Formula:C14H18ClN3O2S
  • Formula Weight:327.83
  • MOL File:105628-07-7.mol
Fasudil hydrochloride Property
  • Melting point 220.5°; mp 219.3° (Shirotani)
  • storage temp. Inert atmosphere,Store in freezer, under -20°C
  • solubility H2O: >200 mg/mL
  • form solid
  • color white
  • Water Solubility Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.
  • Merck 14,3942
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
  • InChI InChI=1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H
  • InChIKey LFVPBERIVUNMGV-UHFFFAOYSA-N
  • SMILES N1(S(C2=CC=CC3=C2C=CN=C3)(=O)=O)CCCNCC1.[H]Cl.[H]Cl
  • CAS DataBase Reference 105628-07-7(CAS DataBase Reference)
  • FDA UNII SQ04N8S7BR
  • UNSPSC Code 12352200
Safety
  • Risk Statements  :22
  • Safety Statements  :36-60
  • WGK Germany  :3
  • RTECS  :HM4031166
  • HS Code  :29339900
  • Toxicity :LD50 in mice, rats (mg/kg): 67.5, 59.9 i.v.; 124.5, 123.2 s.c.; 273.9, 335.0 orally (Koga)
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312+P330-P501-P301+P312a-P330-P501a
Fasudil hydrochloride Price More Price(1)
  • Brand: TCI Chemicals (India)
  • Product number: F0839
  • Product name : Fasudil Hydrochloride
  • Purity: 
  • Packaging: 100MG
  • Price: ₹7800
  • Updated: 2022/05/26
  • Buy: Buy

Fasudil hydrochloride Chemical Properties,Usage,Production

  • Indications and Usage Fasudil Hydrochloride is a new drug with a wide range of pharmacological effects, developed by Asahi Kasei Corporation (Japan.) It is a cardiovascular and cerebrovascular drug which improves symptoms of ischemic cerebrovascular disease such as cerebral vasospasm following subarachnoid hemorrhage. It has significant neuroprotective and therapeutic effects for ischemic cerebrovascular disease, and is suited for clinical use, particularly at the grassroots level to reduce mortality and improve quality of life.
  • Mechanisms of Action Fasudil Hydrochloride is an isoquinoline sulfonamide derivative which can relax separated cerebral blood vessels, inhibit the shrinkage of separated blood vessels caused by calcium influx, inhibit different mechanisms of brain blood vessel contraction from contractile agents, and inhibit intracellular calcium ion activity without reducing calcium ion concentration. Fasudil Hydrochloride is an RHO kinase inhibitor which dilates vessels, reduces tension of endothelial cells, and improves microcirculation of brain tissue without producing or exacerbating diversion of blood to the brain, by increasing activity of myosin light chain phosphatase. At the same time, it can protect nerves against apoptosis and promote their regeneration. Fasudil Hydrochloride promotes recovery of neural function and reduces clinical symptoms.
  • Adverse reactions Adverse reactions after use can include intracranial hemorrhage, gastrointestinal bleeding, pulmonary hemorrhage, nasal bleeding, subcutaneous bleeding, and loss of consciousness, etc., as well as abnormal liver function. Low blood pressure, anemia, leukopenia, renal dysfunction, polyuria, rashes, and fever, etc. occur occasionally.
  • Warnings and Precautions Patients with intracranial hemorrhage or possibility thereof, or low blood pressure, should not use. Patients with diabetes mellitus, cerebral arterial sclerosis, severe disturbance of consciousness, subarachnoid hemorrhages with cerebrovascular disorders, and liver or kidney dysfunction, or those over 70 years old, pregnant, or children should use with caution. Breastfeeding women should stop while using the drug. Fasudil Hydrochloride can only be administered via intravenous drip.
  • Description Fasudil hydrochloride, a novel calcium antagonistic vasodilator, was marketed for the treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). Fasudil is also a potent inhibitor of myosin light chain kinase and protein kinase C. In contrast to other calcium channel blockers, which regulate the influx of calcium ions through the cell membrane but not involved in the intracellular regulatory mechanism of the calcium, fasudil was suggested to have an intracellular mode of action in relaxing vascular smooth muscle. In patients with neurological deficits due to vasospasm, fasudil decreased the occurrence of angiographic severe and symptomatic vasospasm and cerebral infarction without decreasing systemic blood pressure. Fasudil is reportedly in clinical trials for acute ischemic stroke, sequelae of cerebral vascular diseases and angina pectoris.
  • Originator Asahi Chemical (Japan)
  • Uses Fasudil monohydrochloride is used in the prevention and treating cardiovascular and cerebrovascular diseases. It is also used in the inhibition of proliferation of vascular smooth muscle cells. It serves as a selective Rho-associated protein kinase (ROCK) inhibitor. Further, it protects against methyl mercury-induced axonal degeneration.
  • Uses vasodilator, potent Rho-kinase inhibitor
  • Definition ChEBI: Fasudil hydrochloride is a hydrochloride obtained by reaction of fasudil with one equivalent of hydrochloric acid. It has a role as an antihypertensive agent, a calcium channel blocker, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor, a neuroprotective agent, a nootropic agent and a vasodilator agent. It contains a fasudil(1+).
  • brand name Eril
  • storage Room temperature
  • References 1) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95 2) Anwar et al. (2013), Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed; Vascul. Pharmacol., 58 140 3) Jiang et al. (2012), Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice; Int. J. Mol. Sci., 13 8293
Fasudil hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Fasudil hydrochloride Suppliers
Global(475)Suppliers
  • Supplier：
    Henan Fengda Chemical Co., Ltd
  • Tel：+86-371-86557731<br/>+86-13613820652
  • Email：info@fdachem.com
  • Country：China
  • ProdList：20235
  • Advantage：58
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60

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Fasudil hydrochloride Spectrum
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