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Cefazedone sodium salt

Cefazedone sodium salt Structure
Cefazedone sodium salt
  • CAS No.63521-15-3
  • Chemical Name:Cefazedone sodium salt
  • CBNumber:CB6878809
  • Molecular Formula:C18H14Cl2N5NaO5S3
  • Formula Weight:570.42503
  • MOL File:63521-15-3.mol
Cefazedone sodium salt Property
Safety
  • Toxicity :LD50 in mice, rats, rabbits, dogs (mg/kg): 6800, 4225, 3200, 3000 i.v. (von Eberstein)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Cefazedone sodium salt Chemical Properties,Usage,Production

  • Originator Cefazedone Sodium,Arocor Holdings Inc.
  • Manufacturing Process A solution of 1 eq. of the tert-butyl ester of 7-aminocephalosporanic acid and 1 eq. of dicyclohexylcarbodiimide in 100 ml of methylene chloride/DMF (1:1) is cooled to 0°C. The mixture is combined with 1 eq. of 3,5-dichloro-4- pyridone-1-acetic acid; after 5 min the ice bath is removed and the mixture agitated for another 30 min at 25°C. The thus-formed urea is filtered off and the filtrate filtered over silica gel (eluent: ethyl acetate/1% methanol). The solvent is concentrated by evaporation, and the thus-obtained tert-butyl ester of 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid is crystallized from ether.
    1 eq. of the tert-butyl ester is dissolved in 30 ml of trifluoroacetic acid. After 30 minutes, the solution is evaporated and the thus-produced 7-(3,5-dichloro- 1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid crystallized from ether.
    1 eq. of the obtained 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido) cephalosporanic acid is dissolved in 60 ml of saturated aqueous sodium bicarbonate solution at a pH of below 7 and combined with 1 eq. of 5-methyl- 1,3,4-thiadiazole-2-thiol in 20 ml of acetone. The reaction solution is agitated for 2 hours at 80°C and at a pH of 6.3 under a nitrogen atmosphere. The acetone is thereupon removed, the solution is washed with ether and acidified to pH 2. The thus-obtained 3-(1-methyltetrazolyl-5-mercaptomethyl)-7-(3,5- dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)-3-cephem-4-carboxylic acid is filtered off and dried. IR spectrum confirmed the structure of cefazedone.
    In practice it is usually used as sodium salt.
  • Therapeutic Function Antibiotic
Cefazedone sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
Cefazedone sodium salt Suppliers
Global(46)Suppliers
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Cefazedone sodium salt Spectrum
63521-15-3, Cefazedone sodium saltRelated Search:
  • 化学试剂
  • 医药原料药
  • C18H14Cl2N5NaO5S3
  • 63521-15-5
  • 钠 (6R,7R)-7-(2-(3,5-二氯-4-氧代吡啶-1(4H)-基)乙酰氨基)-3-(((5-甲基-1,3,4-噻二唑- 2-基)硫代)甲基)-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸酯
  • 头孢西酮钠盐
  • 头孢西酮钠
  • (6R,7R)-7-(2-(3,5-二氯-4-氧代-1(4H)-吡啶基)乙酰氨基)-3-(((5-甲基-1,3,4-硫二唑-2-基)硫)甲基)-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸钠
  • 63521-15-3
  • Cefazedone sodium salt USP/EP/BP
  • Sodium (6R,7R)-7-[[(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • Refosporin sodium salt
  • Nsc304118
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, monosodium salt, (6R-trans)-
  • (6R,7R)-7-[[2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • Cefazedone, sodium salt
  • sodium (6R-trans)-7-[[(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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