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Tipelukast

Tipelukast Structure
Tipelukast
  • CAS No.125961-82-2
  • Chemical Name:Tipelukast
  • CBNumber:CB5855229
  • Molecular Formula:C29H38O7S
  • Formula Weight:530.67282
  • MOL File:125961-82-2.mol
Tipelukast Property
  • Melting point 82-84°C
  • Boiling point 735.3±60.0 °C(Predicted)
  • Density 1.22
  • storage temp. Hygroscopic, Refrigerator, under inert atmosphere
  • solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
  • pka 4.59±0.10(Predicted)
  • form Solid
  • color Off-White to Pale Beige
  • FDA UNII 08379P260O
  • UNSPSC Code 51111800
  • NACRES NA.77
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Tipelukast Chemical Properties,Usage,Production

  • Uses Tipelukast a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model.
  • Definition ChEBI: Tipelukast is an aromatic ketone.
  • Biological Activity Tipelukast is a Leukotriene D4 (LTD4) receptor antagonist and an inhibitor of 5-lipoxygenase (5-LO) and also phosphodiesterases PDE3 and PDE4. It has been found to have antifibrotic and anti-inflammatory activity. Tipelukast has been investigated as a possible treatment for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).
  • in vivo

    Fiftheen min after an aerosolized antigen challenge, and UNDW inhaled 5 min later into the guinea pigs, Tipelukast significantly alters the UNDW-induced bronchoconstriction[1]. Tipelukast (1 and 5 mg/kg) administered intravenously 15 min after antigen challenge reduces the propranolol-induced bronchoconstriction (PIB) in a dose-dependent manner in guinea-pigs[2].

  • IC 50 LTD4: 6.41 (pA2, In guinea-pigs); LTE4: 6.45 (pA2, In guinea-pigs)
Tipelukast Preparation Products And Raw materials
Raw materials
Preparation Products
Tipelukast Suppliers
Global(25)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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  • Supplier： BOC Sciences
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  • Supplier： Energy Chemical
  • Tel：021-58432009<br/>400-005-6266
  • Email：marketing1@energy-chemical.com
  • Country：China
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Tipelukast Spectrum
125961-82-2, TipelukastRelated Search:
  • 医药原料
  • C29H38O7S
  • 125961-82-1
  • 泰鲁司特
  • 化合物 T15647
  • 4-[6-乙酰基-3-[3-[(4-乙酰基-3-羟基-2-丙基苯基)硫]丙氧基]-2-丙基苯氧基]丁酸
  • 125961-82-2
  • Butanoic acid, 4-[6-acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)thio]propoxy]-2-propylphenoxy]-
  • MN-001 (Tipelukast)
  • 4-[6-acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)sulfanyl]propoxy]-2-propylphenoxy]butanoic acid
  • MN 001 (pharMaceutical)
  • KCA 757
  • tipelukast

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