Enfortumab Vedotin
- Product NameEnfortumab Vedotin
- CAS1346452-25-2
- CBNumberCB58080892
- MW0
- MOL FileMol file
Chemical Properties
| form | Liquid |
| color | Colorless to light yellow |
Enfortumab Vedotin Chemical Properties,Usage,Production
Uses
Enfortumab vedotin-ejfv (solution) is an anti-Nectin-4 antibody-drug conjugate. Enfortumab vedotin-ejfv is a fully humanized IgG1 antibody conjugated to the microtubule disrupting agent MMAE (HY-15162) via a protease-cleavable maleimidocaproylvaline-citrulline linker (SGD-1006). Nectin-4 is an adhesion protein involved in cellular processes and tumorigenesis, and Enfortumab vedotin-ejfv is indicated for the inhibition of locally advanced or metastatic urothelial carcinoma[1][2].Synthesis
Synthesis of enfortumab vedotin
References
[1] Halford Z, et al. Enfortumab Vedotin-ejfv: A First-in-Class Anti-Nectin-4 Antibody-Drug Conjugate for the Management of Urothelial Carcinoma. Ann Pharmacother. 2021 Jun;55(6):772-782. DOI:10.1177/1060028020960402[2] Chang E, et al. FDA Approval Summary: Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Carcinoma. Clin Cancer Res. 2021 Feb 15;27(4):922-927. DOI:10.1158/1078-0432.CCR-20-2275
Enfortumab Vedotin Suppliers
Global(18)Suppliers
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| 16314854226; +8616314854226 | inquiry@bocsci.com | 19852 | 58 | ||
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| 027-87008169 17762441161 | info@atagenix.com | 9997 | 58 | ||
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| 021-65675885 18964387627 | customer_service@efebio.com | 11963 | 58 |
Related articles
An antibody drug conjugate: Enfortumab Vedotin
Enfortumab vedotin (EV) is an antibody?drug conjugate (ADC) consisting of a fully humanized monoclonal antibody targeting nectin-4 linked to the microtubule-disrupting agent monomethyl auristatin E (MMAE).
Jan 17，2024