Chemical Properties
| storage temp. | Store at -20°C |
| form | Liquid |
| color | Colorless to light yellow |
Toripalimab Chemical Properties,Usage,Production
Uses
Toripalimab is the first domestic anti-tumor PD-1 antibody in China. Toripalimab is a selective, recombinant, humanized monoclonal antibody against PD-1. Toripalimab is able to bind to PD-1 and block the interaction with its ligands. Toripalimab has exhibited primary anti-tumor effects in tumors such as melanoma, lung cancer, digestive tract tumors, hepatobiliary and pancreatic tumors, neuroendocrine neoplasms, nasopharyngeal carcinoma and urothelial carcinoma[1].in vivo
Toripalimab (0.3-10 mg/kg; i.p.; twice a week, total 6 times) exhibits substantial tumor suppressive efficacy in a dose-dependent manner[3].
| Animal Model: | A genetically modified mouse strain with human PD-1 knocked in (were subcutaneously inoculated with 1 × 106 MC38 cells)[3] |
| Dosage: | 0.3, 1, 3, 10 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); twice a week, total 6 times |
| Result: | Inhibition of tumor growth was observed in a dose-dependent manner with substantial antitumor efficacy in 1, 3, and 10 mg/kg treatment groups. Decreased significantly at the end of the observation period (day 23) |
References
[1] Lin Zhang, et al. Toripalimab: the First Domestic Anti-Tumor PD-1 Antibody in China. Front Immunol. 2022 Jan 12;12:730666. DOI:10.3389/fimmu.2021.730666[2] Keam SJ. Toripalimab: First Global Approval. Drugs. 2019 Apr;79(5):573-578. DOI:10.1007/s40265-019-01076-2
[3] Liu H, et al. Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy. MAbs. 2019 May/Jun;11(4):681-690. DOI:10.1080/19420862.2019.1596513
Toripalimab Suppliers
Global(25)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +1-631-485-4226 | inquiry@bocsci.com | 19934 | 58 | ||
| 18317699790 18317699790 | l202008112023@163.com | 7733 | 58 | ||
| 027-027-16602739303 16602739303 | 673003916@qq.com | 4951 | 58 | ||
| 010-60605840 | psaitong@jm-bio.com | 27756 | 58 | ||
| 51288865780 | sales@biosynth.com | 6031 | 58 | ||
| 9785721070 | info@cellsciences.com | 6307 | 58 | ||
| 33175446423 | support@antibodysystem.com | 6737 | 58 | ||
| 027-65317797 15926423062 | 422450190@qq.com | 10300 | 58 | ||
| 177-54423994 17754423994 | 2853530910@QQ.com | 7999 | 62 | ||
| 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | 7353 | 58 |