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Gamma oryzanol

CAS No.11042-64-1
Chemical Name:Gamma oryzanol
CBNumber:CB5758140
Molecular Formula:C40H58O4
Formula Weight:602.89
MOL File:11042-64-1.mol

Gamma oryzanol Property

Melting point 135-137°C
Boiling point 571.92°C (rough estimate)
Density 0.9751 (rough estimate)
refractive index 1.4760 (estimate)
storage temp. Sealed in dry,Room Temperature
Water Solubility Practically insoluble in water
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form powder to crystaline
color White to Light yellow
Odor little or no odor
Merck 14,6886
LogP 13.205 (est)
CAS DataBase Reference 11042-64-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII SST9XCL51M
UNSPSC Code 41116107
NACRES NA.24

Safety

RIDADR :UN 2811 6.1/PG II
RTECS :RN0050000
HS Code :3822.19.0080
HazardClass :6.1
PackingGroup :II
Toxicity :LD50 oral in rat: > 25gm/kg

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H310
Precautionary statements P501-P270-P262-P264-P280-P361+P364-P302+P352+P310-P405

Gamma oryzanol Price More Price(4)

Brand: TCI Chemicals (India)
Product number: O0172
Product name : γ-Oryzanol
Purity:
Packaging: 25G
Price: ₹3200
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: O0172
Product name : γ-Oryzanol
Purity:
Packaging: 250G
Price: ₹13100
Updated: 2022/05/26
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Brand: ottokemi
Product number: O 1341
Product name : γ-Oryzanol
Purity: 98%
Packaging: 1gm
Price: ₹1035
Updated: 2022/05/26
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Brand: ottokemi
Product number: O 1341
Product name : γ-Oryzanol
Purity: 98%
Packaging: 5gm
Price: ₹1899
Updated: 2022/05/26
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Gamma oryzanol Chemical Properties,Usage,Production

Description Gamma oryzanol is a lipid fraction derived from rice-bran oil. Oryzanol was first isolated from rice-bran oil in the 1950s. Several lipid fractions were isolated from the oil.The third (gamma) fraction isolated was oryzanol.It is made up of a mixture of ferulic acid esters and plant sterols. Similar in structure to cholesterol, the phytosterols and triterpenes that comprise oryzanol include campesterol, stigmasterol, beta sitosterol, cycloartanol, and cycloartenol. Because phytosterols are poorly absorbed, it has been suggested that they may reduce blood cholesterol by inhibiting intestinal cholesterol absorption.In contrast, the ferulic acid portion of gamma oryzanol is easily absorbed into the body's tissues. Ferulic acid also has demonstrated antioxidant properties in vitro.
Chemical Properties White to Off-White Solid
Occurrence Gamma oryzanol is found in rice-bran oil, which is commercially available in Japan for use in salad oils and frying.Crude rice-bran oil contains approximately 1.56% oryzanol.Of the 180 mg of plant sterols found in the typical American diet，about 4% is gamma-oryzanol.One cup of brown rice provides 18 mg gamma oryzanol, whereas white rice provides 4mg. The ferulic acid portion of gamma oryzanol is naturally found in the bran of cereals, and in fruits and vegetables.Ferulic acid is also a metabolite of caffeic acid found in coffee.
Uses Gamma Oryzanol is a mixture of 6 substances derived from rice bran oil, including sterols and ferulic acid, called Cycloartanyl Ferulate or Triterpene alcohol ferulate. It has been approved in Japan for several conditions, including menopausal symptoms, mild anxiety, stomach upset, and high cholesterol. In the US, it is widely used as a sports supplement, as well as for reducing cholesterol. gamma oryzanol is widely used as a food additive, pharmaceutical material. In cosmetic area, the application to creams and sunscreens exploiting its skin age resistor function and ultraviolet absorbing effect.
Preparation Extraction of gamma oryzanol from processes oil.
Gamma oryzanol can be extracted by liquid-liquid extraction method by using organic solvent or by using supercritical extraction method. The following procedure was followed to extract gamma oryzanol from the oil.
Rice Bran Oil (1 kg)→NaOH and water was added→Stirred and stored for one day at room temperature→Acidified to pH 4 using H2SO4→Heated to 80°C→50g NaCl was added→Oily layer was obtained→ Methanol was added→ Mixture was cooled to 0°C for 2 hrs.→ Waxy component precipitated→ Solution of 5g H2SO4 in 300 ml methanol→ Stored for one day→ Stirred at 40°C to remove/evaporate methanol→ To 100g residue 100g n-hexane was added→ Solvent Distillation→ Treatment of 100 ml methanol was given→ Residue was extracted 3 times with 50ml 0.5N→ methanolicNaOH→ Neutralised with methanolic acetic acid to pH 6.8-7→ Stored to precipitate gamma oryzanol.
The yield of gamma oryzanol was found to be 2.2%
Definition ChEBI: Gamma-Oryzanol (TN) is a triterpenoid.
General Description Gamma oryzanol is found in the by-products of the rice industry, such as rice bran and rice bran oil. It exhibits a wide range of biological activities, including anticarcinogenic, anti-inflammatory, antihyperlipidemic, and neuroprotective properties, which are primarily due to its high antioxidant capacity.
Side effects Gamma oryzanol has no side effects for horses, dogs or humans.
Toxicity studies on animals demonstrate that gamma oryzanol is a very safe compound. No significant side-effects have been reported in human trials at the above noted recommended dosage.
Some research suggests that gamma oryzanol taken in moderately high amounts (up to 600 mg per day) for several months can cause dry mouth, sleepiness, hot flushes, irritability, and light headedness in some individuals.
Safety Profile A poison by skin contact. Moderately toxic by intravenous route. Low toxicity by ingestion. Experimental reproductive effects. When heated to decompositionit emits acrid smoke and irritating vapors.
Dosage A typical dosage of gamma oryzanol is 500 mg daily.