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2-Bromobiphenyl

Description Uses synthesis

2-Bromobiphenyl

CAS No.2052-07-5
Chemical Name:2-Bromobiphenyl
CBNumber:CB5733745
Molecular Formula:C12H9Br
Formula Weight:233.1
MOL File:2052-07-5.mol

2-Bromobiphenyl Property

Melting point 1.5-2 °C(lit.)
Boiling point 297-298 °C(lit.)
Density 1.352 g/mL at 25 °C(lit.)
refractive index n20/D 1.628(lit.)
Flash point 113 °C
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Sparingly, Heated), Methanol (Slightly)
form Liquid
Specific Gravity 1.352
color Clear colorless
Water Solubility Insoluble
BRN 1863156
Stability Stable, but light sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference 2052-07-5(CAS DataBase Reference)
FDA UNII GXS4234YXD
NIST Chemistry Reference 1,1'-Biphenyl, 2-bromo-(2052-07-5)
EPA Substance Registry System 2-Bromobiphenyl (2052-07-5)

Safety

Hazard Codes :Xi,Xn
Risk Statements :36/37/38-20/21/22
Safety Statements :23-24/25-37/39-26-36
WGK Germany :3
TSCA :Yes
HS Code :29036990

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H302-H317-H411-H372
Precautionary statements P273-P305+P351+P338

2-Bromobiphenyl Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: 252247
Product name : 2-Bromobiphenyl
Purity: 96%
Packaging: 5G
Price: ₹5264.45
Updated: 2022/06/14
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Brand: ALFA India
Product number: ALF-B21840-14
Product name : 2-Bromobiphenyl, 98%
Purity:
Packaging: 25g
Price: ₹34013
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-B21840-06
Product name : 2-Bromobiphenyl, 98%
Purity:
Packaging: 5g
Price: ₹4582
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-B21840-03
Product name : 2-Bromobiphenyl, 98%
Purity:
Packaging: 1g
Price: ₹2008
Updated: 2022/05/26
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2-Bromobiphenyl Chemical Properties,Usage,Production

Description 2-Bromobiphenyl is an important intermediate, which can be used to synthesize 2,2'-dibromo-9,9'-spirobifluorene, 3-bromo-9-(9-phenylfluoren-9-yl)carbazole and phenanthrene compounds.
Uses
2-Bromobiphenyl can be used as reference compound to investigate extraction efficiency of solid-phase microextraction fibers, based on methacrylic acid-trimethylolpropanetrimethacrylate copolymers.
synthesis Carry out all catalytic reactions in reaction vessels open to the air. Charge a round-bottom flask with the newly purchased or freshly recrystallized aryl boronic acid (2.0 mmol), 1,2-dibromobenzene, powdered K3PO4 (2.2 mmol) and toluene (2.5 mL) of technical quality. Stir the mixture vigorously. Heat the mixture to 80 °C for 10 minutes. Add (0.2 mol%) of catalyst by syringe as a 2.5 ml of toluene solution to the mixture. Take the samples periodically from the reaction mixture. Quench the reaction with water. Extract the mixture with ethyl acetate. Analyze the reaction by GC-MS. At the end of catalytic reaction, cool the reaction mixture to room temperature. Quench the mixture with water (adjusted to an appropriate pH when biaryls with acidic or basic groups has to be extracted). Extract the mixture with ethyl acetate (3×40 mL). Dry the combined extracts (MgSO4). Evaporate the combined extracts to dryness. Purify the crude material by flash chromatography on silica gel.
Physical properties 2-Bromobiphenyl has a melting point of 1.5-2 °C, so it is a colorless liquid at room temperature. It boils at 297-298 °C. Its density at 25℃ is 1.352 g/mL. In general, 2-bromobiphenyls are stable, but they are not compatible with oxidants.
Uses It is used as an intermediate of organic synthesis and pharmaceutical. It also can react with norborn-2-ene to get 5-phenyl-1,2,3,4,4a,8b-hexahydro-1,4-methanobiphenylene, in synthesis of a novel trispirocyclic hydrocarbon. It is used as a reference compound to investigate extraction efficiency of solid-phase micro extraction fibers, based on methacrylic acid-trimethylolpropanetrimethacrylate copolymers.
Synthesis Reference(s) The Journal of Organic Chemistry, 44, p. 3037, 1979 DOI: 10.1021/jo01331a016
Tetrahedron Letters, 21, p. 845, 1980 DOI: 10.1016/S0040-4039(00)71521-8
General Description Clear liquid. Insoluble in water.
Air & Water Reactions Insoluble in water.
Reactivity Profile 2-Bromobiphenyl is sensitive to light. Low reactivity.
Fire Hazard Flash point data for 2-Bromobiphenyl are not available. 2-Bromobiphenyl is probably combustible.