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Physalaemin

Physalaemin Structure
Physalaemin
  • CAS No.2507-24-6
  • Chemical Name:Physalaemin
  • CBNumber:CB5674482
  • Molecular Formula:C58H84N14O16S
  • Formula Weight:1265.44
  • MOL File:2507-24-6.mol
Physalaemin Property
  • storage temp. −20°C
  • solubility Soluble in DMSO
  • InChIKey SHSUJLMLURFKID-PYQGFWJGNA-N
  • FDA UNII H0T4KV6B9J
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Physalaemin Chemical Properties,Usage,Production

  • Description Physalaemin is an oligopeptide that is originally derived from the skin of the South American frog Physalaemus fuscumaculatus. It belongs to the class of kinins and shares a similar chemical structure and mode of action with Substance P. It is a potent vasodilator and has hypotensive effects.
  • Uses Physalaemin is a neuropeptide found in amphibians that has shown potential in the treatment of Sjogren's disease.?
  • Biological Activity Physalaemin is a non-mammalian tachykinin that selectively binds with high affinity to the neurokinin-1 (NK1) receptor.
  • in vitro

    Physalaemin (PHY), an undecapeptide with the sequence pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, is a member of the tachykinin family of neuropeptides. PHY is very close to the mammalian tachykinin substance P (SP) in its function and chemical composition, and SP is well studied and characterized. Physalaemin is a bradykinin potentiating peptide (BPP-5a).

  • target

    Neurokinin-1 (NK1) receptor

  • References [1] Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. DOI:10.1002/bip.21519
    [2] Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. DOI:10.1248/CPB.54.827
    [3] Hypotensive effect of eledoisin, physalaemin and related peptides in man DOI: 10.1007/BF00535905
    [4] Physalaemin Inhibits Thyrotropin Secretion in Rats DOI: 10.1055/s-0029-1210457
    [5] Action of Physalaemin on the Ionic Transport Across the Frog Skin: Archives of Physiology and Biochemistry: Vol 105, No DOI: 10.1055/s-0029-1210457
Physalaemin Preparation Products And Raw materials
Raw materials
Preparation Products
Physalaemin Suppliers
Global(79)Suppliers
  • Supplier：
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  • Supplier：
    TargetMol Chemicals Inc.
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    Nanjing TGpeptide
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Physalaemin Spectrum
2507-24-6, PhysalaeminRelated Search:
  • Peptide
  • 标准品
  • 其他生化试剂
  • 多肽
  • 生化试剂
  • Tachykinins
  • Peptides
  • BioChemical
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • C58H84N14O16S
  • C58H84N14O16S1
  • 化合物 T19518
  • PHYSALAEMIN肽
  • 泡蛙肽
  • 2507-24-6
  • L-Methioninamide, 5-oxo-L-prolyl-L-alanyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-tyrosylglycyl-L-leucyl-
  • Physalaemin, ≥97% (HPLC)
  • Physalemin
  • Physalaemine
  • L-pGlu-L-Ala-L-Asp-L-Pro-L-Asn-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2
  • 5-Oxo-L-Pro-L-Ala-L-Asp-L-Pro-L-Asn-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2
  • GLP-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
  • PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 ACOH 3H2O
  • PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
  • PYROGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET NH2
  • PHYSALAEMIN ACOH 3H2O
  • PHYSALAEMIN
  • PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
  • Physalemin(7CI,8CI,9CI)
  • FI 6422

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