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GR 82334

GR 82334 Structure
GR 82334
  • CAS No.129623-01-4
  • Chemical Name:GR 82334
  • CBNumber:CB5476231
  • Molecular Formula:C69H91N15O16
  • Formula Weight:1386.55
  • MOL File:129623-01-4.mol
GR 82334 Property
  • Boiling point 1788.6±65.0 °C(Predicted)
  • Density 1.42±0.1 g/cm3(Predicted)
  • storage temp. −20°C
  • form Powder
  • pka 4.31±0.19(Predicted)
  • Water Solubility Soluble to 1 mg/ml in water
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

GR 82334 Chemical Properties,Usage,Production

  • Uses GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats[1].
  • in vivo

    GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul)[1].GR 82334 (10 nM-1 μM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency[2].

    Animal Model:3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats[2]
    Dosage:10 nM, 100 nM, and 1 μM
    Administration:Lntrathecal injection between vertebrae L4 and L5?
    Result:Increased heat-induced foot withdrawal latency in mice.
  • References [1] A Lecci,et al.Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci DOI:10.1016/0024-3205(92)90165-l
    [2] Antje Brand, et al. ?Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat.PLoS One. 2010 Dec 21;5(12):e15162. DOI:10.1371/journal.pone.0015162
GR 82334 Preparation Products And Raw materials
Raw materials
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GR 82334 Spectrum
129623-01-4, GR 82334Related Search:
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • BioChemical
  • Antagonist
  • Tachykinins
  • Peptides
  • C69H91N15O16
  • 129623-01-4
  • L-Tryptophanamide, 5-oxo-L-prolyl-L-alanyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-tyrosyl-(αS,5S)-α-(2-methylpropyl)-6-oxo-1,7-diazaspiro[4.4]nonane-7-acetyl-
  • pglu-ala-asp-pro-asn-lys-phe-tyr-pro(spiro-γ-lactam-leu-trp-nh2
  • [[(S,S)PRO-LEU(SPIRO-GAMMA-LACTAM)]9,10, TRP11]PHYSALAEMIN (1-11)
  • PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-PRO(SPIRO-GAMMA-LACTAM)-LEU-TRP-NH2
  • GR 82334

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