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IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D

IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D Structure
IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D
  • CAS No.112898-42-7
  • Chemical Name:IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D
  • CBNumber:CB5503627
  • Molecular Formula:C19H25ClN2
  • Formula Weight:316.87
  • MOL File:112898-42-7.mol
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IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D Chemical Properties,Usage,Production

  • Uses Imipramine-d3 (hydrochloride) is deuterium labeled Imipramine (hydrochloride). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5][6].
  • References [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
    [2] Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52(2):281-292. DOI:10.1038/s12276-020-0389-x
    [3] Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413(2):311-7. DOI:10.1016/j.bbrc.2011.08.093
    [4] Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. DOI:10.1002/(sici)1099-0461(1999)13:63.0.co;2-7
    [5] Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20. DOI:10.1016/j.bbi.2015.01.016
    [6] Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264(4):2195-8. PMID:2914900
IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D Preparation Products And Raw materials
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IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D Suppliers
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  • Supplier： SHANGHAI ZZBIO CO., LTD.
  • Tel：15102117276<br/>19921389125
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  • Country：China
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IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D Spectrum
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