ChemicalBook > CAS DataBase List > DESIPRAMINE HYDROCHLORIDE

DESIPRAMINE HYDROCHLORIDE

DESIPRAMINE HYDROCHLORIDE Structure
DESIPRAMINE HYDROCHLORIDE
  • CAS No.58-28-6
  • Chemical Name:DESIPRAMINE HYDROCHLORIDE
  • CBNumber:CB4723947
  • Molecular Formula:C18H23ClN2
  • Formula Weight:302.84
  • MOL File:58-28-6.mol
DESIPRAMINE HYDROCHLORIDE Property
  • Melting point 214-2160C
  • Flash point 11 °C
  • storage temp. 2-8°C
  • solubility H2O: 50 mg/mL
  • form powder
  • color white to off-white
  • Water Solubility Soluble to 100 mM in water
  • FDA UNII 1Y58DO4MY1
  • NCI Drug Dictionary desipramine hydrochloride
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H302-H315-H317-H319-H334-H335
  • Precautionary statements P280-P301+P312+P330-P302+P352-P305+P351+P338
DESIPRAMINE HYDROCHLORIDE Price More Price(5)
  • Brand: Sigma-Aldrich(India)
  • Product number: D3900
  • Product name : Desipramine hydrochloride
  • Purity: ≥98% (TLC), powder
  • Packaging: 1G
  • Price: ₹5174.35
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: PHR1723
  • Product name : Desipramine Hydrochloride
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 400MG
  • Price: ₹13769.4
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D3900
  • Product name : Desipramine hydrochloride
  • Purity: ≥98% (TLC), powder
  • Packaging: 5G
  • Price: ₹18857.15
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D-906
  • Product name : Desipramine hydrochloride solution
  • Purity: 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging: 1ML
  • Price: ₹2407.3
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D3900
  • Product name : Desipramine hydrochloride
  • Purity: ≥98% (TLC), powder
  • Packaging: 25G
  • Price: ₹73296.08
  • Updated: 2022/06/14
  • Buy: Buy

DESIPRAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

  • Chemical Properties White To Off-White Solid
  • Originator Pertofran,Geigy,UK,1963
  • Uses Tricyclic antidepresant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.
  • Uses Desipramine hydrochloride has been used:
    • to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
    • to protect unselective damage to the?noradrenergic system
    • as a norepinephrine re-uptake inhibitor to treat rats for lesioning

  • Uses Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.
  • Definition ChEBI: The hydrochloride salt of desipramine.
  • Manufacturing Process Oxidative coupling of o-nitrotoluene gives 4,4'-dinitrodibenzyl which is reduced with hydrogen to the diamine. The diamine is pyrolyzed to give dihydrobenzazepine. This is reacted with N-(3-chloropropyl)-Nmethylbenzamine to give N-benzyldesipramine. This is debenzylated by reductive cleavage and then reacted with HCl.
  • brand name Norpramin (Sanofi Aventis); Pertofrane (Sanofi Aventis).
  • Therapeutic Function Psychostimulant
  • General Description The structure and salient properties of desipramine hydrochloride,10,11-dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine monohydrochloride, 5-(3-methylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride(Norpramin, Pertofrane), are discussed under the heading,Imipramine. Among tricyclics, desipramine would be consideredwhen few anticholinergic effects or a low level of sedationare important. It is a SNERI.
  • Biological Activity Tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (K i values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).
  • Biochem/physiol Actions Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.
  • Safety Profile Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: decreased urine volume, sodium level changes, chlorine level changes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO, and HCI.
  • storage Desiccate at +4°C
DESIPRAMINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
DESIPRAMINE HYDROCHLORIDE Suppliers
Global(158)Suppliers
  • Supplier：
    Standardpharm Co. Ltd.
  • Tel：86-714-3992388
  • Email：overseasales1@yongstandards.com
  • Country：United States
  • ProdList：14332
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    AFINE CHEMICALS LIMITED
  • Tel：+86-0571-85134551
  • Email：sales@afinechem.com
  • Country：China
  • ProdList：15349
  • Advantage：58
  • Supplier：
    LEAP CHEM CO., LTD.
  • Tel：+86-852-30606658
  • Email：market18@leapchem.com
  • Country：China
  • ProdList：24727
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
DESIPRAMINE HYDROCHLORIDE Spectrum
58-28-6, DESIPRAMINE HYDROCHLORIDERelated Search:
  • NORPRAMIN
  • Adrenoceptor
  • Neurotransmitters
  • Neurotransmission (Obesity)
  • Neurotransmission
  • Biogenic Amine Transport InhibitorsObesity Research
  • Biogenic Amine Transport Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • 杂质对照品
  • 抑制剂
  • 药靶配体
  • 临床检测标准物质
  • 有机化工原料
  • 医药原料
  • 标准品
  • 小分子抑制剂
  • 合成
  • Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 4 nM) than the serotonin transporter (Ki = 61 nM).
  • C18H22N2HCl
  • C18H23ClN2
  • DESIPRAMINE HYDROCHLORIDE 盐酸去甲咪嗪 |CAS 58-28-6
  • 盐酸去甲咪嗪,10 MM DMSO 溶液
  • 盐酸去甲咪嗪/A1A
  • 甲醇中盐酸地昔帕明
  • 地昔帕明/去甲丙米嗪-[D3]盐酸盐/精确称量
  • 地西帕明-[13C,D3]草酸盐/精确称量
  • 盐酸丙咪嗪EP杂质A
  • 化合物GW 788388
  • 去甲咪嗪盐酸盐
  • 地昔帕明盐酸盐,盐酸去甲咪嗪
  • 盐酸德司拉明
  • 盐酸去甲咪嗪 USP标准品
  • 地昔帕明盐酸盐
  • 盐酸地昔帕明 EP标准品
  • 地昔帕明盐酸盐/盐酸丙咪嗪杂质A (EP)
  • 盐酸米帕明杂质A
  • 去郁敏杂质
  • 盐酸丙米嗪杂质Ⅱ(盐酸去甲丙米嗪)N-甲基-10,11-二氢-5H-二苯并[B,F]氮杂-5-丙胺盐酸盐
  • 盐酸丙米嗪杂质Ⅱ(盐酸去甲丙米嗪)N-甲基-10，11-二氢-5H-二苯并[b，f]氮杂-5-丙胺盐酸盐
  • 盐酸地昔帕明溶液,1000PPM
  • 地昔帕明盐酸盐溶液,100PPM
  • 5-[3-(甲基氨基)丙基]-5H-二苯并[B,F]氮杂卓盐酸盐
  • 3-(5,6-二氢苯并[B][1]苯并氮杂卓-11-基)-N-甲基丙-1-胺盐酸盐
  • 3-(5,6-二氢苯并[B][1]苯并氮杂卓-11-基)-N-甲基-丙-1-胺盐酸盐
  • 3-(5,6-二氢苯并[B][1]苯并氮杂卓-11-基)-N-甲基丙-1-胺
  • 3-(5,6-二氢苯并[B][1]苯并氮杂卓-11-基)-N-甲基-丙-1-胺
  • 盐酸去甲咪嗪杂质
  • [3-(10,11-二氢-5H-二苯并[B,F]氮杂卓-5-基)丙基]甲胺盐酸盐
  • 去甲丙咪嗪盐酸盐
  • 盐酸去甲丙咪嗪
  • 盐酸地昔帕明
  • 盐酸去甲咪嗪
  • 58-28-6
  • Desipramine hydrochloride, 10 mM in DMSO
  • Desmethylimipramine hydrochloride/Desipramine HCL
  • Desmethylimipramine-[d3] hydrochloride
  • Imipramine Hydrochloride EP Impurity A as Hydrochloride

Home

My