Description
Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production
of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid
gland activity.
Chemical Properties
white to beige powder
Uses
3,5-Diiodo-L-tyrosine Dihydrate is a thyroid hormone receptor agonist.
Uses
It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters,
and other illnesses accompanied by thyrotoxicity.
Uses
3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity.
Definition
ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis.
Synthesis
Diiodotyrosine, 3,5-diiodotyrosine (25.2.1), is synthesized by directly iodinating
tyrosine with iodine in the presence of sodium iodide in aqueous ethylamine, or in a
mixture of acetic and hydrochloric acids with the addition of hydrogen peroxide.
Purification Methods
It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.]
