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Ascomycin

Ascomycin Structure
Ascomycin
  • CAS No.11011-38-4
  • Chemical Name:Ascomycin
  • CBNumber:CB5406331
  • Molecular Formula:C43H69NO12
  • Formula Weight:792.01
  • MOL File:11011-38-4.mol
Ascomycin Property
  • Melting point 158 - 161°C
  • storage temp. -20°C
  • solubility Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).
  • form White crystalline solid
  • color White
  • biological source goat
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
  • EWG's Food Scores 1
  • UNSPSC Code 12352203
  • NACRES NA.41
Safety
  • RTECS  :CI7570000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H351-H413-H361-H302
  • Precautionary statements P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501
Ascomycin Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: SAB2501813
  • Product name : Anti-Nprl3 antibody produced in goat
  • Purity: affinity isolated antibody, buffered aqueous solution
  • Packaging: 100μG
  • Price: ₹53135.7
  • Updated: 2022/06/14
  • Buy: Buy

Ascomycin Chemical Properties,Usage,Production

  • Description Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays anti-inflammatory effects in skin diseases3. Cell permeable and active in vivo.
  • Uses A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases.
  • General Description An ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.
  • Biochem/physiol Actions Product does not compete with ATP.
  • Enzyme inhibitor This antifungal antibiotic (FW = 792.02 g/mol; CAS 104987-12-4; Solubility: 50 mM in DMSO), also known as FK520, isolated from Streptomyces hygroscopicus, is also a powerful immunosuppressant. Note that ascomycin is a structural analogue of tacrolimus (or FK506) and, as such, operates by a similar mechanism of action (See Tacrolimus). Ascomycin inhibits allogenic T-lymphocyte proliferation and calcineurin phosphatase activity.
  • References 1) Hatanaka et al. (1988), FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physio-chemical and biological characteristics; J. Antibiot. (Tokyo), 41 1592 2) Petros et al. (1991), NMR studies of an FK506 analogue [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding; J. Med. Chem., 34 2925 3) Mollison et al. (1999), A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases; J. Invest. Dermatol., 112 729
Ascomycin Preparation Products And Raw materials
Raw materials
Preparation Products
Ascomycin Suppliers
Global(204)Suppliers
  • Supplier：
    Hangzhou ICH Biofarm Co., Ltd
  • Tel：+86-0571-28186870;<br/>+undefined8613073685410
  • Email：sales@ichemie.com
  • Country：China
  • ProdList：1015
  • Advantage：58
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29858
  • Advantage：58
  • Supplier：
    Xiamen AmoyChem Co., Ltd
  • Tel：+86-86-5926051114<br/>+8615060885618
  • Email：sales@amoychem.com
  • Country：China
  • ProdList：6383
  • Advantage：58
Ascomycin Spectrum
11011-38-4, AscomycinRelated Search:
  • API
  • Immunosuppressant
  • 杂质对照品
  • 科研原料
  • 精细化工原料
  • 生物化工
  • 医药原料
  • 医药化工类
  • 化学试剂
  • 标准品，对照品
  • 原料
  • 原料药
  • 对照品-中药对照品
  • 抑制剂
  • 医药原料
  • 医药原料药
  • 抗肿瘤类药物及免疫抑制剂
  • 免疫抑制剂
  • BioChemical
  • Antibiotics A-F
  • Antibiotics A to Z
  • Antibiotics
  • 杂质1(子囊霉素)
  • 子襄霉素
  • EP杂质B-子囊霉素异构体
  • (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26AS)-8-乙基-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-十六氢-5,19-二羟基-3-[(1E)-2-[(1R,3R,4R)-4-羟基-3-甲氧基]-1-甲基乙烯基]-14,16二甲氧基4,10,12,18四甲基-15,19-环氧-3H-吡啶并[2,1-C][1,4]氧杂氮杂环十三碳-1,7,20,21(4H,23H)-四酮
  • 子囊霉素1
  • 子囊霉素、长川霉素
  • ASCOMYCIN子囊霉素
  • 紫囊霉素
  • 子囊霉素 ASCOMYCIN
  • 子囊霉素
  • 11011-38-4
  • 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
  • 17-Ethyl-1,14-dihydroxy-12-[1-(4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl]-23,25-dimethoxy-13,19,2
  • Ascomycin 1
  • Ascomycin (Immunomycin,FK-520)
  • Ascomycin (Immunomycin
  • CS-740
  • Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem
  • Ascomycin, >=98.5%
  • RP23-177M10.6
  • nitrogen permease regulator-like 3 (S. cerevisiae)
  • CGTHBA
  • Anti-Nprl3 antibody produced in goat
  • Nsc106410
  • Aids-093221
  • Aids093221
  • 15,19-Epoxy-3H-pyrido[2,1-C][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26as)-
  • Ascomycin (FK520)
  • (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
  • ASCOMYCIN (IMMUNOMYCIN, FR-900520) \ INH IBITS CALCINEURIN (PP2B)
  • AAG
  • IMMUNOMYCIN
  • FK-520
  • FR-900520
  • ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS VAR ASCOMYCETICUS
  • ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS

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