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Ascomycin

Ascomycin Structure
Ascomycin
  • CAS No.104987-12-4
  • Chemical Name:Ascomycin
  • CBNumber:CB2406330
  • Molecular Formula:C43H69NO12
  • Formula Weight:792.01
  • MOL File:104987-12-4.mol
Ascomycin Property
  • Melting point 153-157°C
  • Boiling point 868℃
  • Density 1.19±0.1 g/cm3(Predicted)
  • Flash point >110°(230°F)
  • storage temp. Inert atmosphere,Store in freezer, under -20°C
  • solubility ≥38.9 mg/mL in DMSO; insoluble in H2O; ≥98.6 mg/mL in EtOH
  • form Powder
  • pka 9.97±0.70(Predicted)
  • color White to off-white
  • Water Solubility Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water
  • InChIKey ZDQSOHOQTUFQEM-AMASXYNMSA-N
  • FDA UNII AUF4U5NSJK
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • Hazard Codes  :Xn,F
  • Risk Statements  :20/21/22-36-11
  • Safety Statements  :36/37-16
  • RIDADR  :UN 1648 3 / PGII
  • WGK Germany  :3
  • RTECS  :KD4185000
  • F  :10
  • HS Code  :29419090
  • NFPA 704:
    0
    3 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H225-H302+H332-H319-H302-H312-H332
  • Precautionary statements P210-P305+P351+P338-P261-P280h-P301+P312a-P304+P340-P321-P501a
Ascomycin Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: A3835
  • Product name : Ascomycin from Streptomyces hygroscopicus var. ascomyceticus
  • Purity: 
  • Packaging: 1MG
  • Price: ₹27679.53
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: A-094
  • Product name : Ascomycin solution
  • Purity: 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging: 1ML
  • Price: ₹26240.9
  • Updated: 2022/06/14
  • Buy: Buy

Ascomycin Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Uses Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.
  • Uses A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases
  • Uses Ascomycin is a macrocyclic lactone closely related to tacrolimus and rapamycin. Ascomycin is isolated from several species of Streptomyces and was first reported in 1988. Ascomycin exhibits limited, potent antifungal activity but has found considerable utility as an immunosuppressant.
  • Definition ChEBI: A macrolide that is produced by the fermentation of Streptomyces hygroscopicus and exhibits strong immunosuppressant properties.
  • Biological Activity ascomycin (fk 520, fr900520) is a novel neutral macrolide immunosuppressant, isolated from the cultured broth of streptomyces hygroscopicus subsp. yakushimaensis no. 7238.
  • in vitro ascomycin (fk 520, fr900520) suppressed lymphocyte reaction in a dose dependent fashion. ascomycin was non-toxic at concentrations less than 3,200 nm, at which the percent inhibition was 18.9%. ascomycin showed antifungal activity against aspergillus fumigatus ifo 5840. ascomycin had no inhibitory effect on bacteria or yeast at 100 μg/ml [1].
  • in vivo ascomycin was dose-dependently effective and clearly prolonged skin allograft survival at 3.2 mg/kg or more, though all skin allografts were rejected within 7 days in rats treated intramuscularly with olive oil. ascomycin, dissolved in olive oil, showed no adverse effect when administered intraperitoneally to ddy mice (male, 8 weeks old) at 100 mg/kg [1].
  • target peptidyl-prolyl cis-trans isomerase
  • storage -20°C
  • References [1] hatanaka h, kino t, miyata s, inamura n, kuroda a, goto t, tanaka h, okuhara m. fr-900520 and fr-900523, novel immunosuppressants isolated from a streptomyces. ii. fermentation, isolation and physico-chemical and biological characteristics. j antibiot (tokyo). 1988;41(11):1592-601.
Ascomycin Preparation Products And Raw materials
Raw materials
Preparation Products
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Ascomycin Spectrum
104987-12-4, AscomycinRelated Search:
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  • C43H69NO12
  • 104978-12-4
  • (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-[(1E)-2-[(1R,3R,4R)-4-羟基-3-甲氧基环已基]-1-甲基乙烯基]-17-乙基-1,14-二羟基-23,25-二甲氧基-13,19,21,27-四甲基-11,28-二噁-4-氮杂三环[22.3.1.04,9]二十八碳-18-烯-2,3,10,16-四酮
  • 子囊霉素,10 MM DMSO 溶液
  • ASCOMYCIN,CALCINEURIN/PP2B抑制剂
  • 子囊霉素杂质A
  • 子囊霉素19异构体
  • 他克莫司杂质5(子囊霉素)(他克莫司EP杂质A)(他克莫司UPS相关杂质杂质A)
  • 他克莫司 杂质A (EP)子囊霉素(USP)
  • 杂质A (EP)子囊霉素(USP)
  • COMYCIN(FK 520)
  • (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26AS)-8-乙基-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-十六氢-5,19-二羟基-3-[(1E)-2-[(1R,3R,4R)-4-羟基-3-甲氧基环己基]-1-甲基乙基]-14,16-二甲氧基-4,10,12,18-四甲基-15,19-环氧-3H-吡啶[2,1-C][1,4]氧杂环TRICOSINE-11,7,20,21(4H,23H)-三酮
  • 他克莫司EP杂质A
  • 他克莫司USP相关物质A
  • 他克莫司相关杂质A
  • 长川霉素/子囊霉素
  • 子囊霉素:他克莫司-亚甲基杂质
  • 他克莫司相关化合物A(子囊霉素)
  • 他克莫司 A
  • 子囊霉素(他克莫司相关化合物A)

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