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Ethyl lactate

Description Chemical properties Uses Production method Usage limit Toxicity

Ethyl lactate

CAS No.97-64-3
Chemical Name:Ethyl lactate
CBNumber:CB5292231
Molecular Formula:C5H10O3
Formula Weight:118.13
MOL File:97-64-3.mol

Ethyl lactate Property

Melting point -26°C
alpha D14 -10°
Boiling point 154 °C (lit.)
Density 1.031 g/mL at 25 °C (lit.)
vapor pressure 81hPa at 20℃
FEMA 2440 | ETHYL LACTATE
refractive index 1.4124
Flash point 54.6±6.4 °C
solubility Miscible with water (with partial decomposition), ethanol (95%), ether, chloroform, ketones, esters, and hydrocarbons.
pka 13.21±0.20(Predicted)
form clear liquid
color Colorless
Odor Mild characteristic.
optical activity [α]20/D 10.5°, neat
biological source synthetic
Odor Type fruity
Water Solubility 100g/L at 20℃
JECFA Number 931
Merck 14,3817
Dielectric constant 13.1（25℃）
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey LZCLXQDLBQLTDK-UHFFFAOYSA-N
LogP 0.7 at 25℃
Substances Added to Food (formerly EAFUS) ETHYL LACTATE
FDA 21 CFR 172.515; 175.105; 73.1001
CAS DataBase Reference 97-64-3(CAS DataBase Reference)
EWG's Food Scores 1-4
FDA UNII F3P750VW8I
NIST Chemistry Reference Propanoic acid, 2-hydroxy-, ethyl ester(97-64-3)
EPA Substance Registry System Ethyl lactate (97-64-3)
UNSPSC Code 12164502
NACRES NA.21

Safety

Hazard Codes :Xi
Risk Statements :10-37-41
Safety Statements :24-26-39
RIDADR :1192
WGK Germany :1
RTECS :OD5075000
HazardClass :3.2
PackingGroup :III
HS Code :29181100
Hazardous Substances Data :97-64-3(Hazardous Substances Data)

NFPA 704:

	2
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H226-H315-H318-H335
Precautionary statements P210-P233-P240-P280-P303+P361+P353-P305+P351+P338

Ethyl lactate Price More Price(10)

Brand: Sigma-Aldrich(India)
Product number: W244015
Product name : Ethyl lactate
Purity: natural, ≥98%, FCC, FG
Packaging: 1SAMPLE-K
Price: ₹5347.55
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: W244015
Product name : Ethyl lactate
Purity: natural, ≥98%, FCC, FG
Packaging: 1KG
Price: ₹10446.13
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: W244015
Product name : Ethyl lactate
Purity: natural, ≥98%, FCC, FG
Packaging: 5KG
Price: ₹44079.4
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: W244015
Product name : Ethyl lactate
Purity: natural, ≥98%, FCC, FG
Packaging: 10KG
Price: ₹52836.83
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: W244007
Product name : Ethyl lactate
Purity: ≥98%, FCC, FG
Packaging: 1SAMPLE-K
Price: ₹5141.88
Updated: 2022/06/14
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Ethyl lactate Chemical Properties,Usage,Production

Description Ethyl lactate, an ester of lactic acid, is a "green" solvent derived from processing corn. Lactate esters solvents are commonly used solvents in the paints and coatings industry and have numerous attractive advantages including being 100% biodegradable, easy to recycle, noncorrosive, noncarcinogenic, and nonozone depleting.
Ethyl lactate is an important organic ester, which is biodegradable and can be used as food additive, in perfumery, as flavour chemicals and solvent, which can dissolve acetic acid cellulose and many resins (Tanaka et al., 2002). It is a particularly attractive solvent for the coatings industry as a result of its high solvency power, high boiling point, low vapour pressure and low surface tension. Ethyl lactate is a desirable coating for wood, polystyrene and metals and also acts as a very effective paint stripper and graffiti remover. It has replaced solvents including N-methyl Pyrrolidone (NMP) (Reisch, 2008), toluene, acetone and xylene, which has resulted in the workplace being made a great deal safer.

ethyl lactate structure
Chemical properties Ethyl lactate appears as colorless to light yellow transparent liquid with rum, fruit and cream aroma. The freezing point:-25°C; the boiling point: 154°C, specific rotation [a] 14d:-10°. It is easily soluble in ethanol, acetone, ether, esters and other organic solvents; there is some degree of hydrolysis upon being miscible with water. Mouse oral LD50: 2.5g/kg, ADI is subject to no special provisions (FAO/WHO, 1994).

Ethyl lactate is a common solvent in pharmaceutical, cosmetic, detergent, coatings, food and fragrance production. It is considered biodegradable in its natural form and it is exempt from many restrictions imposed in accordance with the disposal of chemicals. For this reason it is a highly desirable product in a “green”, environmentally conscious industry. In the presence of water, acids and bases the chemical will hydrolyse into ethanol and lactic acid.
Uses Ethyl Lactate is a solvent manufactured from l (+) lactic acid which is miscible in water and most organic solvents and is cleared for use as a flavoring agent. it is a naturally occurring constituent of california and spanish sherries. it is a clear, colorless, nontoxic liquid of low volatility, having a ph of 7–7.5. it is used as a food and beverage flavoring agent.Ethyl lactate is used in the electronics industry to remove salts and fat from circuit boards; it is also a component in paint strippers.
Production method Ethyl lactate is usually produced by the esterification of lactic acid with ethanol using sulfuric acid catalyst.
Usage limit FEMA (mg/mL): Soften drink: 5.4; Cold drinks: 17; Candies 28; baked goods 71; pudding class 8.3; gums 580 to 3100; alcohol 1000; syrup 35.
Take moderate as limit (FDA § 172.515, 2000).
Toxicity ADI is not subject to specific special provisions (FAO/WHO, 1994).
GRAS (FEMA).
LD50 2500 mg/kg (mouse, oral).
Chemical Properties Ethyl Lactate is a colorless liquid with a light ethereal, buttery odor. It miscible in water, alcohols, ketones , esters, hydrocarbons, ether and oil. The odor threshold is reported to be 0.89 mg/m3 and the odor nuisance threshold to be 65 mg/m3.
Occurrence Ethyl lactate is reported to be found in apple, citrus fruits, pineapple, peas, sauerkraut, vinegar, bread, beer, grape brandy, rum, whisky, cider, sherry, wine, cocoa, banty beer, plum brandy and pear brandy. It has been approved by the US FDA for food use.
Uses Ethyl lactate is used as a solvent for nitrocellulose, cellulose acetate, and many cellulose ethers and resins. It is also used in lacquers, paints, enamels, varnishes, stencil sheets, safety glass and flavoring. Ethyl lactate is furthermore used in some cosmetic formulations in soaps, detergents, creams and lotions with a maximum concentration of 0.2 %. In recent years it has been used as degreaser as a substitute for trichloroethylene.
Definition ChEBI: Ethyl 2-hydroxypropanoate is the ethyl ester obtained of 2-hydroxypropanoic acid. It has a role as a metabolite. It is a secondary alcohol, a lactate ester and an ethyl ester. It is functionally related to a 2-hydroxypropanoic acid.
Preparation Ethyl lactate is produced by the esterification of lactic acid with ethanol in the presence of a little mineral oil, or by combination of acetaldehyde with hydrocyanic acid to form acetaldehyde cyanhydrin. This is followed by treatment with ethanol (95%) and hydrochloric or sulfuric acid. Purification is achieved using fractional distillation. The commercial product is a racemic mixture.
Synthesis Reference(s) Synthetic Communications, 19, p. 1335, 1989 DOI: 10.1080/00397918908054542
General Description A clear colorless liquid with a mild odor. Flash point 115°F. Denser than water and soluble in water. Vapors heavier than air.
Air & Water Reactions Flammable. Soluble in water.
Reactivity Profile Ethyl lactate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Health Hazard Inhalation of concentrated vapor may cause drowsiness. Contact with liquid causes mild irritation of eyes and (on prolonged contact) skin. Ingestion may cause narcosis.
Fire Hazard HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety Ethyl lactate is used as a flavoring agent in pharmaceutical preparations, and is found in food products. The estimated acceptable daily intake for lactic acid is 12.5 mg/kg body-weight.
In general, lactate esters have an oral LD50 > 2000 mg/kg; and the inhalation LC50 is generally above 5000 mg/m3. They have the potential of causing eye and skin irritation (on prolonged contact), but not sensitization. Ethyl lactate is moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. There is low oral and skin contact toxicity; although ingestion may cause nausea, stomach and throat pain, and narcosis. Inhalation of concentrated vapor of ethyl lactate may cause irritation of the mucous membranes, drowsiness, and narcosis.
LD50 (rat, oral): >5.0 g/kg
LD50 (mouse, oral): 2.5 g/kg
LD50 (mouse, SC): 2.5 g/kg
LD50 (mouse, IV): 0.6 g/kg
LD50 (rabbit, skin): >5.0 g/kg
Veterinary Drugs and Treatments Ethyl lactate shampoo can be used when an antibacterial shampoo (bacteriostatic and bactericidal) is needed particularly in animals with surface and superficial pyodermas that cannot tolerate benzoyl peroxide. It also has keratoplastic effect, which provides anti-seborrheic activity.
A lipid soluble compound, ethyl lactate penetrates hair follicles and sebaceous glands where bacterial lipases convert it into lactic acid and ethanol, which are responsible for its antibacterial action. It is not as active as benzoyl peroxide against staphylococcal organisms, but is less irritating and drying.
storage Stable at normal temperature and pressure. Ethyl lactate is a flammable liquid and vapor. Store in a cool, dry, and well-ventilated location away from any fire hazard area, in a tightly closed container.
Incompatibilities Incompatible with bases or strong alkalis and may cause fire or explosion with strong oxidizing agents.
Toxics Screening Level The Initial Threshold Screening Level (ITSL) for ethyl lactate is 20 μg/m3 based on an annual averaging time.
Regulatory Status GRAS listed. Reported in the EPA TSCA Inventory.