ChemicalBook > CAS DataBase List > Pyrazofurin
Pyrazofurin
- CAS No.30868-30-5
- Chemical Name:Pyrazofurin
- CBNumber:CB5276253
- Molecular Formula:C9H13N3O6
- Formula Weight:259.22
- MOL File:30868-30-5.mol
Pyrazofurin Property
- Boiling point 584.4±50.0 °C(Predicted)
- Density 1.785±0.06 g/cm3(Predicted)
- storage temp. -20°C
- solubility DMSO, Water (Slightly)
- pka 7.17±0.50(Predicted)
- form powder
- color white to light brown
- optical activity [α]/D -49 to -39°, c = 0.5 in H2O
- Water Solubility H2O: 5mg/mL, clear (warmed)
- Stability Hygroscopic
- EWG's Food Scores 1
- FDA UNII 4B15044GQZ
- NCI Drug Dictionary pyrazofurin
- UNSPSC Code 12352200
- NACRES NA.77
- Symbol(GHS)
- Signal word
- Hazard statements
- Precautionary statements
Pyrazofurin Price
More Price(2)
- Brand: Sigma-Aldrich(India)
- Product number: SML1502
- Product name : Pyrazofurin
- Purity: ≥98% (HPLC)
- Packaging: 5MG
- Price: ₹14873.55
- Updated: 2022/06/14
- Buy: Buy
- Brand: Sigma-Aldrich(India)
- Product number: SML1502
- Product name : Pyrazofurin
- Purity: ≥98% (HPLC)
- Packaging: 25MG
- Price: ₹59862.25
- Updated: 2022/06/14
- Buy: Buy
Pyrazofurin Chemical Properties,Usage,Production
- Uses Geldanamycin (G304500) derivative.
- Definition ChEBI: A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group.
- Biochem/physiol Actions Pyrazofurin serves as an effective drug against HIV (human immuno virus), vaccinia virus, West Nile viral infection.
- Enzyme inhibitor This pyrimidine nucleoside (FW = 261.23 g/mol), also known as pyrazomycin, exhibits antineoplastic activity and inhibits cell proliferation and DNA synthesis in cells by inhibiting orotidylate decarboxylase (uridine 5'-phosphate synthase). Pyrazofurin, also known as 3,b-D-ribofuranosyl-4- hydroxypyrazole-5-carboxamide, is the prodrug of the 5’-phosphate derivative. Target(s): adenosylhomocysteinase; 5-aminoimidazole-4- carboxamide-1-b-D-ribofuranosyl 5'-monophosphate formyltransferase; orotate phosphoribosyltransferase; orotidylate decarboxylase, or UMP synthase.
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in vivo
Pyrazofurin (0.25-5 mg/kg; subcutaneous injection; 5 days) has an ameliorative effect in mice infected with Rift Valley fever virus[4].
Animal Model: Rift Valley fever virus-infected female Swiss Webster mice aged 3-4 weeks old[4] Dosage: 0.25, 2.5 and 10 mg/kg Administration: Subcutaneous injection (s.c.); 5 days Result: Increased survival rate and generally prolonged life at 0.25 mg/kg dose.
Was uniformly ineffective at protecting mice from death but did increase the time to death at 2.5 mg/kg dose.
Had toxic to mice at high doses (10 mg/kg).
Pyrazofurin Preparation Products And Raw materials
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30868-30-5, PyrazofurinRelated Search:
- Pyrazole-3-carboxamide 1-(5-methyl-1H-pyrazol-3-yl)methanamine 5'-deoxypyrazofurin 4-hydroxypyrazole 5-METHYL-1H-PYRAZOLE-3-CARBOXAMIDE 5-methyl-1H-pyrazole-3-carbaldehyde 3-(Aminomethyl)pyrazole 3-ETHYL-1H-PYRAZOLE-5-CARBALDEHYDE (1H-PYRAZOL-3-YL)METHANOL 4-AMINO-1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXAMIDE HYDROCHLORIDE 2H-PYRAZOLE-3-CARBALDEHYDE Pyrazofurin 3,5-Dimethylpyrazole 2,2'-Oxydipropanol
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- 抑制剂
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- 化合物 PYRAZOFURIN
- 3-((2S,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)-4-羟基-1H-吡唑-5-甲酰胺
- 吡唑霉素 Ⅰ
- 化合物 T16690
- 吡唑呋喃菌素
- 吡唑霉素
- 吡唑呋林
- 30868-30-5
- 3-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxy-1H-pyrazole-5-carboxamide
- Pyrazomycin Ⅰ
- --Pyrazofurin
- β-Pyrazofurin
- 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-β-D-ribofuranosyl-
- Pyrozofurin
- Pyrazomycin
- Pyrazole-3-carboxamide, 4-hydroxy-5-beta-L-ribofuranosyl-
- PRZF
- 4-Hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide
- 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-beta-D-ribofuranosyl-
- A-23813
- 47599
- 4-HYDROXY-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLE-5-CARBOXAMIDE MONOHYDRATE
- PYRAZOFURIN MONOHYDRATE
- pyrazofurin
- pirazofurin
- nsc143095
- compound47599
- beta-pyrazomycin
- antibiotica23813
- 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamide
- 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamid
- 3-beta-d-ribofuranosyl-4-hydroxypyrazole-5-carboxamide
