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REVERSE T3

Description

REVERSE T3

CAS No.5817-39-0
Chemical Name:REVERSE T3
CBNumber:CB5221268
Molecular Formula:C15H12I3NO4
Formula Weight:650.97
MOL File:5817-39-0.mol

REVERSE T3 Property

Melting point 234-238 °C(lit.)
Boiling point 534.6±50.0 °C(Predicted)
Density 2.387±0.06 g/cm3(Predicted)
Flash point 9℃
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly)
form powder
pka 2.17±0.20(Predicted)
color Pale Beige to Brown
Stability Light Sensitive
InChI InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
InChIKey HZCBWYNLGPIQRK-LBPRGKRZSA-N
SMILES C(O)(=O)[C@H](CC1=CC=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)N
NCI Dictionary of Cancer Terms T-3; triiodothyronine
FDA UNII 8NZ4Y08T96
UNSPSC Code 41116107
NACRES NA.26

Safety

Hazard Codes :Xn,T,F
Risk Statements :36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements :36-45-36/37-16
RIDADR :UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany :3
RTECS :AY6750000
F :8
HS Code :29379000

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302+H312+H332
Precautionary statements P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312

REVERSE T3 Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: T-075
Product name : 3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution
Purity: 100?μg/mL in methanol with 0.1N NH3, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1ML
Price: ₹13898.5
Updated: 2022/06/14
Buy: Buy

REVERSE T3 Chemical Properties,Usage,Production

Description Either a derivative or precursor of thyroxine. Triiodothyronine increases themetabolic rate and oxygen consumption of animal tissues. Used in biochemical research, medicine (metabolic insufficiency).
Chemical Properties Beige Powder
Uses Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.
Uses One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.
Definition ChEBI: 3,3',5'-triiodo-L-thyronine is a 3,3',5'-triiodothyronine. It is a tautomer of a 3,3',5'-triiodo-L-thyronine zwitterion.
Biological Activity 3,3',5'-triiodo-l-thyronine (reverse t3 or rt3) and 3,5,3'-triiodo-l-thyronine (t3) are the metabolism of thyroxine (t4) [1]. 3,3',5'-triiodo-l-thyronine is thyroid hormone receptors trα and trβ antagonist [1].thyroid hormones play important roles in the development of the mammalian brain by acting on migration and differentiation of neural cells, synaptogenesis, and myelination. the actions of thyroid hormones are mediated by nuclear thyroid hormone receptors (trs) and regulation of gene expression. trs have been also involved in adult brain function. in adult mice, trα1 deletion and a dominant negative mutant receptor expression induce consistent behavioral changes leading to severe anxiety and morphological changes in the hippocampus [2].the rt3 was about 1,000-fold less active at the thyroid hormone receptors trα and trβ compared with 3,3',5-triiodo-l-thyronine and commonly described as inactive [1].it has been reported that rt3 activates a native form of trα, trδα1, which lacks a nuclear localization signal and functions in the cytoplasm. through this action, rt3 initiates actin polymerization, particularly in astrocytes and neurons [3].
References [1] nicod p, burger a, staeheli v, et al. a radioimmunoassay for 3, 3′, 5′-triiodo-l-thyronine in unextracted serum: method and clinical results[j]. the journal of clinical endocrinology & metabolism, 1976, 42(5): 823-829.
[2] bernal j. thyroid hormone receptors in brain development and function[j]. nature clinical practice endocrinology & metabolism, 2007, 3(3): 249-259.
[3] senese r, cioffi f, de lange p, et al. thyroid: biological actions of ‘nonclassical’thyroid hormones[j]. journal of endocrinology, 2014, 221(2): r1-r12.